JaLCDOI 10.18926/AMO/31618
FullText URL fulltext.pdf
Author Nishiya, Koji| Hisakawa, Naoko| Tahara, Kiyoshi| Matsumori, Akinori| Ito, Hiroyuki| Hashimoto, Kozo| Nakatani, Ko| Takatori, Kazuhiro|
Abstract <p>To evaluate the efficacy and safety of additive triple disease modifying anti-rheumatic drug (DMARD) combination therapy of a low dose of sulfhydryl compounds inverted question markD-penicillamine, bucillamine or tiopronin inverted question mark, sulfasalazine (SSZ) and methotrexate (MTX) as a treatment for rheumatoid arthritis (RA) patients, we studied a total of 33 Japanese RA patients (6 males, 27 females). At 1 or 2 months after simultaneous administration of the 3 above-mentioned DMARDs was begun, significant improvements were seen in markers of joint inflammation, i.e., erythrocyte sedimentation rate and C-reactive protein in sera. At 6 months, clinical improvement judged by the physicians' overall assessment of joint symptoms and laboratory data was observed in 29 (88%) of the 33 RA patients. No marked effect was observed in the other 4 (12%) patients, however. We observed no significant adverse reaction to this therapy. This suggests that additive triple DMARD combination therapy of a low dose of sulfhydryl compounds, SSZ and MTX could be a useful drug therapy for the treatment of RA patients, even those who are refractory.</p>
Keywords rheumatoid arthritis joint inflammation disease modifying anti-rheumatic drug combination therapy
Amo Type Brief Note
Published Date 1999-12
Publication Title Acta Medica Okayama
Volume volume53
Issue issue6
Publisher Okayama University Medical School
Start Page 275
End Page 279
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 10631383
Web of Science KeyUT 000084414300006