JaLCDOI 10.18926/AMO/31995
FullText URL fulltext.pdf
Author Takeuchi, Mamoru| Morita, Kiyoshi| Iwasaki, Tatsuo| Toda, Yuichiro| Oe, Katsunori| Taga, Naoyuki| Hirakawa, Masahisa|
Abstract <p>To elucidate the effect of adrenomedullin (AM) on fluid homeostasis under cardiopulmonary bypass (CPB), we investigated the serial changes in plasma AM and other parameters related to fluid homeostasis in 13 children (average age, 28.2 months) with congenital heart disease during cardiac surgery under CPB. Arterial blood and urine samples were collected just after initiation of anesthesia, just before commencement of CPB, 10 min before the end of CPB, 60 min after CPB, and 24 h after operation. Plasma AM levels increased significantly 10 min before the end of CPB and decreased 24 h after operation. Urine volume increased transiently during CPB, which paralleled changes in AM. Simple regression analysis showed that plasma AM level correlated significantly with urinary vasopressin, urine volume, urinary sodium excretion, and plasma osmolarity. Stepwise regression analysis indicated that urine volume was the most significant determinant of plasma AM levels. Percent rise in AM during CPB relative to control period correlated with that of plasma brain natriuretic peptide (r = 0.57, P &#60; 0.01). Our results suggest that AM plays an important role in fluid homeostasis under CPB in cooperation with other hormones involved in fluid homeostasis.</p>
Keywords adrenomedullin cardiopulmonary bypass vasopressin pediatric cardiac surgery brain natriuretic peptide
Amo Type Article
Published Date 2001-08
Publication Title Acta Medica Okayama
Volume volume55
Issue issue4
Publisher Okayama University Medical School
Start Page 245
End Page 252
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11512567
Web of Sience KeyUT 000170367200007