JaLCDOI 10.18926/AMO/32825
FullText URL fulltext.pdf
Author Nakajima, Hirofumi| Shimomura, Hiroyuki| Iwasaki, Yoshiaki| Ikeda, Fusao| Umeoka, Fumi| Chengyu, Piao| Taniguchi, Hideaki| Ohnishi, Yasuhiro| Takagi, Shin-jiro| Fujioka, Shin-ichi| Shiratori, Yasushi|
Abstract <p>To improve the efficacy of interferon (IFN) treatment for chronic hepatitis C, we have proposed the twice-daily administration of IFN-beta as a promising induction therapy. In this study, we demonstrated differences between the clearance of circulating HCV-RNA and the induction of anti-viral actions during the first 2 weeks of treatment. Nine patients with a high viral load and genotype 1b were randomly assigned to 3 groups: group A received 3MU of IFN-beta twice a day at intervals of 5 and 19 h; group B received 3MU of IFN-beta twice a day at intervals of 10 and 14 h; group C received 6MU of IFN-alpha once a day with ribavirin. The expression of OAS2, PKR, and MxA in peripheral blood mononuclear cells (PBMCs) were quantified by real-time polymerase chain reaction method. The viral clearance showed a bi-phasic pattern, and those in the second phase of groups A and B were significantly steeper than that of group C. The peak level of OAS2 during the first phase was correlated with the first phase decay. The MxA expression tended to be higher in group A and B than in group C. The expression of these 3 proteins tended to decrease at day 6 in group C, but increase in groups A and B. These might make differences in the viral decay during the second phase</p>
Keywords chronic hepatitis C(CHC) interferon(IFN)beta hepatitis C virus(HCV)dynamics antiviral actions real time PCR
Amo Type Article
Published Date 2003-10
Publication Title Acta Medica Okayama
Volume volume57
Issue issue5
Publisher Okayama University Medical School
Start Page 217
End Page 225
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 14679399
Web of Sience KeyUT 000186186000002