JaLCDOI 10.18926/AMO/32818
FullText URL fulltext.pdf
Author Ishikawa, Takaki| Tachibana, Toshiaki| Ishikawa, Hiroshi| Miyaishi, Satoru| Ishizu, Hideo|
Abstract <p>Healthy subjects 40 years old were used as controls in a study of stellate cells (S-100 protein-containing cells, or S-100 cells) in subjects with chronic alcoholism and fatty liver or fatty cirrhosis. S-100 cells were sparsely found in the adenohypophysis of control subjects, and these cells sometimes formed small clusters. However, in chronic alcoholics with fatty liver or fatty cirrhosis, the number of stellate cells in the anterior pituitary tended to be 17 times higher than it was in the control group. No increase in the number of S-100 positive cells that constitute the large and small follicles in the intermediate pituitary. The physiological function of the S-100 protein has not yet been identified. The fact that an increase in prolactin-secreting and growth hormone-secreting cells, as well as a decrease in gonadotrophs were observed in the hypophysis of alcoholics suggests that the function of stellate cells may be closely related to these phenomena. Our results also imply that the stellate cells found in the anterior and intermediate pituitary differ in function although they both produce S-100 proteins.</p>
Keywords S-100 protein pituitary alcoholism
Amo Type Article
Published Date 2003-04
Publication Title Acta Medica Okayama
Volume volume57
Issue issue2
Publisher Okayama University Medical School
Start Page 53
End Page 58
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 12866744
Web of Sience KeyUT 000182520400002
JaLCDOI 10.18926/AMO/32816
FullText URL fulltext.pdf
Author Ishikawa, Takaki| Miyaishi, Satoru| Tachibana, Toshiaki| Yamamoto, Yuji| Ishizu, Hideo|
Abstract <p>In this study we used paraffin-embedded human pituitary obtained from 248 autopsy cases and identified mixed cell follicles by the immunohistochemical method. We examined the number and size of the mixed cell follicles, and the ratio of each component cell of these follicles, in the anterior pituitary at various age groups. The number of follicles increased with age, and the size of the follicles also tended to enlarge with age. Statistical analysis showed that a high correlation existed between age and the number or the size of the mixed cell-follicles formed by various adenohypophyseal cells. In addition, when the proportions of the different cell types that formed the follicles were examined, sex differences were observed with aging for the GH cells, the PRL cells, and the gonadotroph (GTH) cells, while no changes were observed with aging in both men and women for the ACTH cells and TSH cells. These results indicate that the number, size, and ratio of each component cell of follicles in the anterior pituitary are adequately applicable for the purpose of age estimation in routine forensic medicine.</p>
Keywords mixed cell-follicle human anterior pituitary age estimation
Amo Type Article
Published Date 2003-04
Publication Title Acta Medica Okayama
Volume volume57
Issue issue2
Publisher Okayama University Medical School
Start Page 83
End Page 89
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 12866748
Web of Sience KeyUT 000182520400006