JaLCDOI 10.18926/AMO/31825
FullText URL fulltext.pdf
Author Makita, Ryuji| Kokaze, Akatsuki| Ohtsu, Tadahiro| Ishikawa, Mamoru| Matsunaga, Naomi| Karita, Kanae| Yoshida, Masao| Tanaka, Nobukazu| Yamamoto, Minoru| Hayashi, Junichi| Takashima, Yutaka| Kitamoto, Kiyoshi|
Abstract <p>Reduced nicotinamide adenine dinucleotide (NADH) dehydrogenase subunit 2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism, is reportedly associated with longevity in the Japanese population. The ND2-237Met genotype may exert resistance to atherogenic diseases, such as myocardial infarction or cerebrovascular disorders. To investigate whether ND2-237 Leu/Met polymorphism is associated with yearly changes in serum lipid levels, we conducted a longitudinal study of 107 healthy Japanese male subjects. Analysis of covariance revealed that the interaction between the ND2-237 Leu/Met genotypes and habitual drinking was significantly associated with yearly changes in serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDLC) levels (p0.036 and p0.006, respectively). In multiple regression analysis, daily drinking was significantly and positively associated with yearly changes in serum LDLC levels in men with ND2-237Met (p0.026). After adjusting for covariates, yearly changes in serum LDLC levels were significantly lower in non-daily drinkers with ND2-237Met than in those with ND2-237Leu (p0.047). These results suggest that ND2-237Met has a beneficial impact on yearly changes in serum LDLC in non-daily drinkers but not in daily drinkers.</p>
Keywords daily alcohol consumption longevity total cholesterol low-density lipoprotein cholesterol NADH dehydrogenase
Amo Type Original Article
Published Date 2009-12
Publication Title Acta Medica Okayama
Volume volume63
Issue issue6
Publisher Okayama University Medical School
Start Page 331
End Page 338
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 20035289
Web of Sience KeyUT 000273145900004