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ID 11444
Eprint ID
11444
FullText URL
Title Alternative
Synthesis of Novel Temperature-responsive Polymer Gel of Poly(aspartic acid)s
Author
Uehara, Hiroki
Tanimoto, Fumiaki
Kitamura, Yoshiro
Yoshizawa, Hidekazu
Abstract
Recently, thermo-responsive polymer gels have been studied in various research fields such as drug delivery system. One of represetative thermo-responsive polymer gels is poly(N-isopropylacrylamide) gel (PNIPAAm) that has a rapid and reversible volume phase transition. However, PNIPAAm is not biodegradable, resulting in limitation of its use in medical fields. Novel thermo-responsive polymer gel was prepared by closslinking of isopropylamine modified poly(succinimide) (IPA-PSI) (Poly[α,β -(DL-aspartate isopropyl amide)-co-(succinimide)]) with hexamethylenediamine. Because of peptide bonds in backbone, therefore, it is expected to possess biodegradability and biocompatibility. These gels changed their volume in response to change of environment such as temperature, pH and concentration of salt in water. Crosslinkage density and substitution degree of IPA-PSI affected volume phase transition bahavior of the gel.
Keywords
Thermo-responsive polymer gel
Biodegradable polymer
Poly(aspartic acid)
Lower Critical Solution Temperature(LCST)
Drug delivery system(DDS)
Published Date
2006-03-15
Publication Title
岡山大学環境理工学部研究報告
Publication Title Alternative
Journal of the Faculty of Environmental Science and Technology, Okayama University
Volume
volume11
Issue
issue1
Publisher
岡山大学環境理工学部
Publisher Alternative
Faculty of Environmental Science and Technology, Okayama University
Start Page
103
End Page
106
ISSN
1341-9099
NCID
AN10529213
Content Type
Departmental Bulletin Paper
Related Url
http://www.okayama-u.ac.jp/user/est/homeJapan.html
language
日本語
OAI-PMH Set
岡山大学
File Version
publisher
Refereed
False
Sort Key
16
Eprints Journal Name
fest