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ID 16144
Eprint ID
16144
FullText URL
Thumnail 97_249.pdf 572 KB
Title Alternative
Treatment of Advanced Malignant LymphomaPart 1. Combination Chemotherapy for Advanced Non Hodgkin's Lymphoma with Adriamycin, Vincristine, Ifosfamide, and Prednisolone.
Author
Ueoka, Hiroshi
Abstract
Twenty-nine patients with advanced non-Hodgkin's lymphoma (3 with follicular medium-sized cell type, 1 with follicular mixed cell type, 5 with diffuse small cell type, 17 with diffuse medium-sized cell type and 3 with lymphoblastic type) were treated with a four-drug combination chemotherapy consisting of adriamycin, vincristine, ifosfamide and prednisolone (AVIP). The objective response rate was 89% with a complete response rate of 55%. The median duration of complete response was 10 months ranging from 2 months to 6 years and 7 months. The median survival time calculated by the Kaplan-Meier method was 3 years and 9 months. As for the 17 patients with diffuse medium-sized cell type lymphoma, the complete response rate was 71%. Median survival time has not been reached, and 62% of the patients were alive after 5 years. Performance status, and presence or absence of systemic symptoms were important factors in predicting survival. The myelosuppressive toxicity of the regimen was well tolerated. No patients encountered life-threatening toxicity. This study demonstrated the efficacy of the AVIP regimen in patients with non-Hodgkin's lymphoma, and it appeared that patients with diffuse medium-sized cell type lymphoma were potentially curable.
Keywords
Non-Hodgkin's lymphoma
Combination chemotherapy
Prognostic factor
Published Date
1985-04-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume97
Issue
issue3-4
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
249
End Page
261
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/97/3-4/97_3-4_249/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma