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ID 13967
Eprint ID
13967
FullText URL
Thumnail 105_119.pdf 1.59 MB
Title Alternative
Studies on anti-HTLV-Ⅰ antibody in interstitial lung diseases Part 1. Western blot analysis for anti-HTLV-Ⅰ antibody and HTLV-Ⅰ related reaction in DBP and IIP
Author
Ueno, Katsumi
Abstract
By the immunofluorescent assay for the anti-HTLV-Ⅰ antibody, the serum of many patients with diffuse panbronchiolitis (DBP) and idiopathic interstitial pneumonia (IIP) show two types of cytoplasmic fluorescence. One is a granular pattern in the MT-1 cell and diffuse pattern in the MT-2 cell. This is the typical pattern for the anti-HTLV-Ⅰ antibody. The other is a diffuse pattern in the MT-1 and/or MT-2 cells. This pattern has been designated as HTLV-Ⅰ related reaction. These serum reactions were investigated by Western blot analysis with an MT-2 cell lysate as antigen. Although about 20% of the patients with DBP and IIP were considered to be suffering from HTLV-Ⅰ associated bronchiolo-alveolar disorder (HABA) because they showed the typical pattern of anti-HTLV-Ⅰ antibody, only those patients with HABA were shown to have the antibodies against HTLV-Ⅰ specific proteins (p19, p24, p28, pr53 and gp68). On the other hand, the patients with HTLV-Ⅰ related reaction had neither the antibodies against any HTLV-Ⅰ proteins nor the other protein components of MT-2. Thus, Western blot analysis revealed that antibodies against HTLV-Ⅰ specific proteins were present only in the patients with HABA.
Keywords
びまん性汎細気管支炎
特発性間質性肺炎
HTLV-Ⅰ抗体
HTLV-Ⅰ関連反応
Western blot 法
Published Date
1993-02-27
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume105
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
119
End Page
126
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/105/1-2/105_1-2_119/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma