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ID 13983
Eprint ID
13983
FullText URL
Thumnail 105_127.pdf 1.6 MB
Title Alternative
Studies on anti-HTLV-Ⅰ antibody in interstitial lung diseases Part 2. Anti-HTLV-ⅠIgG, IgM, and IgA antibodies in HTLV-Ⅰ associated bronchiolo-alveolar disorder (HABA)
Author
Ueno, Katsumi
Abstract
To study the pathogenesis of HTLV-Ⅰassociated bronchiolo-alveolar disorder (HABA), Western blot analysis was performed using MT-2 cell lysate antigens on the serum of 6 patients with HABA, 7 patients with adult T cell leukamia (ATL), 14 asymptomatic carriers and 9 healthy controls. Five(83%) of the 6 HABA patients were positive for anti-HTLV-Ⅰ IgA antibodies, although all 7 ATL patients and 11 of the 14 asymptomatic carriers were negative. All HABA and ATL patients and asymptomatic carriers were positive for anti-HTLV-Ⅰ IgG antibodies. Four(67%) of the 6 HABA patients, 2(29%) of the 7 ATL patients and 9(64%) of the 14 asymptomatic carriers were positive for anti-HTLV-Ⅰ IgM antibodies. Statistically there was little difference in the incidences of anti-HTLV-Ⅰ IgG and IgM antibodies among HABA and ATL patients and asymptomatic carriers, but the HABA patients showed a significantly higher incedence of IgA antibody than the ATL patients and asymptomatic carriers. Since specific IgA antibodies are produced in the local infected mucosa and part of the IgA antibodies are transferred into the serum, in conclusion, the anti-HTLV-Ⅰ IgA antibodies in HABA patients reflect the localization of HTLV-Ⅰ in lungs which play an important role in the pathogenesis of HABA.
Keywords
HTLV-Ⅰ関連細気管支・肺胞異常症
抗 HTLV-ⅠIgA 抗体
Published Date
1993-02-27
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume105
Issue
issue1-2
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
127
End Page
134
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/105/1-2/105_1-2_127/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma