JaLCDOI 10.18926/AMO/32683
FullText URL fulltext.pdf
Author Sakagami, Kenichi| Saito, Shinya| Shiozaki, Shigehiro| Takasu, Shinji| Matsuno, Tsuyoshi| Fujiwara, Takuzo| Kusaka, Satoshi| Uda, Masashi| Matsuoka, Junji| Naomoto, Yoshio| Gouchi, Akira| Hamazaki, Keisuke| Tanaka, Shinichiro| Orita, Kunzo|
Abstract <p>A retrospective study was carried out in 110 cadaveric kidney transplant recipients to compare the effects of low doses of cyclosporine (CsA), azathioprine (AZP) and steroids (triple-drug therapy) with those of higher doses of steroids plus AZP (conventional immunosuppression). Graft survival rate in the triple-drug therapy was 77%, 69%, and 69% at 1, 3, and 5 years, respectively. This was significantly better than 48%, 34%, and 29% in conventional immunosuppression. The incidence of acute rejection episodes was significantly lower in the triple-drug therapy than in conventional immunosuppression (25% vs 58%). In conclusion, our study shows that triple-drug therapy using low-dose cyclosporine is the safest of the immunosuppressive regimens and provides a beneficial effect on the long-term survival of cadaveric kidney transplants.</p>
Keywords cadaveric kindney transplantation cyclosporine triple-drug therapy
Amo Type Article
Published Date 1992-02
Publication Title Acta Medica Okayama
Volume volume46
Issue issue1
Publisher Okayama University Medical School
Start Page 53
End Page 56
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1561907
Web of Sience KeyUT A1992HH01700010
JaLCDOI 10.18926/AMO/32678
FullText URL fulltext.pdf
Author Sakagami, Kenichi| Saito, Shinya| Shiozaki, Shigehiro| Fujiwara, Takuzo| Haisa, Minoru| Niguma, Takefumi| Kusaka, Satoshi| Uda, Masashi| Matsuno, Tsuyoshi| Takasu, Shinji| Yerdel, Mehmet Ali| Matsuoka, Junji| Tanaka, Shinichiro| Orita, Kunzo|
Abstract <p>One-hundred-nine HLA-haploidentical living related renal transplants have been retrospectively analysed to compare the effect of donor-specific blood transfusion (DST) and different immunosuppressive regimens on graft survival and acute rejection. The recipients were divided into four groups according to the immunosuppressive therapy. Group 1 (n = 44): conventional therapy with posttransplant azathioprine (AZP) + methylprednisolone (MP). Group 2 (n = 25): pretransplant DST + posttransplant AZP + MP. Group 3 (n = 12): triple-drug therapy with posttransplant AZP + MP + cyclosporine (CS). Group 4 (n = 25): pretransplant DST + posttransplant AZP + MP + CS. The five-year actuarial survival rates for groups 1, 2, 3 and 4 were 48%, 73%, 79%, and 89%, respectively. The graft survival rate in group 3 was significantly (p less than 0.01) better than that in group 1. The transfusion effect was reduced, and appears as a 10% improvement in the graft survival in the cyclosporin era compared with a 25% improvement at pre-cyclosporin era. Furthermore, the incidence of the first rejection episode was decreased in recipients that received DST. The present study revealed that DST, as pretransplant conditioning has a definite impact on rejection-free long-term graft survival in HLA-haploidentical living-related kidney recipients and the most favorable outcome in such patients could be achieved by DST pretreatment in conjunction with posttransplant triple-drug therapy including cyclosporine.</p>
Keywords living-related kindney transplantation donor-specific blood transfusion (DST) cyclosporine
Amo Type Article
Published Date 1992-02
Publication Title Acta Medica Okayama
Volume volume46
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 5
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1561899
Web of Sience KeyUT A1992HH01700001
JaLCDOI 10.18926/AMO/31998
FullText URL fulltext.pdf
Author Nakao, Atsunori| Sakagami, Kenichi| Mitsuoka, Shintaro| Uda, Masashi| Tanaka, Noriaki|
Abstract <p>We report a case of retroperitoneal hematoma presenting as femoral nerve pulsy on antiplatelet therapy. The patient, a 78-year-old man who had undergone antiplatelet treatment using ticlopidine, was admitted to our hospital with complaints of sudden-onset low abdominal and back pain. Computed tomography showed an iso-density mass in the right retroperitoneum within the psoas muscle. We made a diagnosis of retroperitoneal hematoma compressing the femoral nerve and performed an operation to remove the hematoma in order to decompress the femoral neuropathy. Postoperatively, the patient rapidly recovered from the femoral neuropathy. In the particular case in which no antagonist against the ticlopidine is available, surgical decompression could produce a good outcome.</p>
Keywords ticlopidine retroperitoneal hematoma
Amo Type Article
Published Date 2001-12
Publication Title Acta Medica Okayama
Volume volume55
Issue issue6
Publisher Okayama University Medical School
Start Page 363
End Page 366
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11779099
Web of Sience KeyUT 000172838400007
JaLCDOI 10.18926/AMO/31132
FullText URL fulltext.pdf
Author Fujiwara, Takuzo| Sakagami, Kenichi| Saito, Shinya| Uda, Masashi| Orita, Kunzo|
Abstract <p>The antidonor immune response was examined in a one haplotype-mismatched renal transplant recipient with an allograft that had been well-functioning for more than 10 years. Although the relative response of the mixed lymphocyte reaction (MLR) was (45.8)% and the MLR responder cells stimulated by donor cells produced measurable amounts of interleukin-2 (IL-2) (11.6 U/ml), the cytotoxic T lymphocytes (CTL) could not be generated against donor cells, even with exogenous IL-2. These results indicate that antidonor CTL precursors were either deleted or inactivated in this recipient.</p>
Keywords renal transplantation long-term stable recipient cytotoxic T lymphocytes
Amo Type Article
Published Date 1994-02
Publication Title Acta Medica Okayama
Volume volume48
Issue issue1
Publisher Okayama University Medical School
Start Page 63
End Page 65
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8191919
Web of Sience KeyUT A1994MY85100011