JaLCDOI 10.18926/AMO/32273
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Author Ucar, Peyman| Gocmen, Cemil| Secilmis, Ata| Karatas, Yusuf| Singirik, Ergin| Onder, Serpil| Dikmen, Atilla| Baysal, Firuz|
Abstract <p>The applications of ultraviolet (UV) light (336 nm) on the upper oesophageal strips of frog elicited relaxant responses in the presence of NaNO2 (50 microM). The tissues were mounted under the tension 0.5 g in an organ bath containing Ringer solution, maintained at 25 degrees C and gassed with 100% O2. The responses were recorded on a kymograph via an isotonic lever. Antimegaloblastic agents, including hydroxocobalamin (1, 10, and 100 microM), cyanocobalamin (1, 10, 25, and 100 microM), and folic acid (1, 10, 50, 100, and 200 microM), significantly attenuated the relaxation response to UV light. Folinic acid (1, 10, 25, and 100 microM), however, enhanced the relaxation. Pyrogallol (50 microM), hydroquinone (50 microM), and diethyldithiocarbamic acid (8 mM) were found ineffective for attenuation, though FeSO4 (200, 400, and 500 microM) and hemoglobin (50 microM), respectively, exerted significant inhibition. L-arginine methylester (500 microM) did not impair UV-induced relaxation. Based on these results, we concluded that a mechanism involving undefined action(s) of antimegaloblastic drugs may cause alterations in the UV light-induced relaxation of the tissue used.</p>
Keywords ultraviolet light frog oesophageal strip hydroxocobalamin cyanocobalamin folic acid
Amo Type Article
Published Date 2000-08
Publication Title Acta Medica Okayama
Volume volume54
Issue issue4
Publisher Okayama University Medical School
Start Page 147
End Page 152
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 10985174
Web of Sience KeyUT 000089132800002