JaLCDOI 10.18926/AMO/32458
FullText URL fulltext.pdf
Author Ohmori, S.| Ubuka, T.| Shimomura, T.| Azumi, T.| Horiuchi, K.|
Abstract <p>FUKUTOME has once reported that isovaleric acid is an isovalthinuria inducer but isovaleric acid-1-C14 administered to a dog does not incorporate into urinary isovalthine and glutamic acid is most strongly labeled among acidic amino acids excreted. Recently, however, KUWAKI has found that liver homogenates of some animals can synthesize C14-labeled S-(isopropylcarboxymethyl) glutathione (GSIV) from isovaleric acid-1-C14 and glutathione, and that GSIV can be converted into isovalthine by kidney homogenate or glutathionase preparation4. For the elucidation of the above discrepancy, FUKUTOME's experiments were repeated by using isovaleric acid-methyl-C14 or-1-C14, and it was again found that these isotopic compounds did not significantly incorporate into urinary isovalthine.</p>
Amo Type Brief Note
Published Date 1964-12
Publication Title Acta Medicinae Okayama
Volume volume18
Issue issue6
Publisher Okayama University Medical School
Start Page 351
End Page 352
NCID AA00041342
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 4221608
NAID 120002311661