Author Watanabe, Akiharu| Taketa, Kazuhisa| Kosaka, Kiyowo|
Published Date 1974-10
Publication Title Acta Medica Okayama
Volume volume28
Issue issue5
Content Type Journal Article
JaLCDOI 10.18926/AMO/32444
FullText URL fulltext.pdf
Author Shiota, Tetsuya| Watanabe, Akiharu| Mitani, Ken| Ito, Toshio| Tobe, Kazuo| Nagashima, Hideo|
Abstract <p>A patient with an unresectable hepatocellular carcinoma (HCC) who survived without active treatment 3 years and 8 months after histological diagnosis is described. The size of the liver, which was already quite huge at the time of diagnosis, changed little during the entire clinical observation. However, 2 months before death, his condition deteriorated rapidly following gastrointestinal bleeding due to the direct invasion of the stomach by HCC. A critical reason for the unusually long-term survival of the patient may stem from the facts that a well-differentiated and bile-producing HCC was extent in most encapsulated-tumor tissues and that liver cirrhosis was not present.</p>
Keywords hepatocellular carcinoma long-term survival well-differenciated type hepatobiliary scintigraphy
Amo Type Article
Published Date 1983-02
Publication Title Acta Medica Okayama
Volume volume37
Issue issue1
Publisher Okayama University Medical School
Start Page 73
End Page 78
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6189368
Web of Sience KeyUT A1983QD83600009
JaLCDOI 10.18926/AMO/32428
FullText URL fulltext.pdf
Author Watanabe, Akiharu| Hayashi, Syosaku| Shiota, Tetsuya| Nagashima, Hideo|
Abstract <p>The blood levels of amino acids, ammonia and pancreatic hormones following the intragastric and intravenous administration of a branched-chain amino acid (BCAA)-enriched solution were comparatively investigated in control subjects and patients with liver cirrhosis. There was no essential difference in the time course of serum amino acid and blood ammonia levels between the intragastric and intravenous infusions. Elevation of serum insulin concentrations in cirrhotic patients was significant only immediately after the administration through the enteral route. However, plasma glucagon levels increased similarly when the BCAA-enriched solution was administered through either route. The results indicate that both enteral and intravenous infusions will have similar therapeutic effects on the impaired protein metabolism in cirrhotic patients with protein-calorie malnutrition.</p>
Keywords amino acied pancreatic hormone ammonia liver cirrhosis intragastric and intravenous infusion
Amo Type Brief Note
Published Date 1983-10
Publication Title Acta Medica Okayama
Volume volume37
Issue issue5
Publisher Okayama University Medical School
Start Page 441
End Page 445
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6417980
Web of Sience KeyUT A1983RN98400008
JaLCDOI 10.18926/AMO/32425
FullText URL fulltext.pdf
Author Watanabe, Akiharu| Ohashi, Yoshito| Nagashima, Hideo|
Abstract <p>Direct drain of the cystic duct and drain of the biliary tract through an internal fistula into the duodenum in a 81-year-old man were endoscopically diagnosed without an operation.</p>
Keywords bile duct anomaly cystic duct pancreatic duct internal fistula
Amo Type Article
Published Date 1983-10
Publication Title Acta Medica Okayama
Volume volume37
Issue issue5
Publisher Okayama University Medical School
Start Page 409
End Page 415
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6650223
Web of Sience KeyUT A1983RN98400004
JaLCDOI 10.18926/AMO/32412
FullText URL fulltext.pdf
Author Shiota, Tetsuya| Watanabe, Akiharu| Takei, Nobuyuki| Hayashi, Shosaku| Obata, Takahiro| Sakata, Tatsuro| Nagashima, Hideo|
Abstract <p>Blood ammonia levels in patients with various liver diseases were determined quantitatively by a simple and rapid method using the Amitest Meter System. The results were compared to those obtained by an enzymatic method and were well correlated. This simple Amitest is also useful in animal experiments, particularly when there is a need to determine blood ammonia levels serially. This paper test was evaluated as being accurate and reliable for clinical and experimental use.</p>
Keywords simple method blood ammonia hyperammonemia liver disease
Amo Type Brief Note
Published Date 1983-04
Publication Title Acta Medica Okayama
Volume volume37
Issue issue2
Publisher Okayama University Medical School
Start Page 159
End Page 162
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6869065
Web of Sience KeyUT A1983QN63900009
JaLCDOI 10.18926/AMO/32406
FullText URL fulltext.pdf
Author Kobayashi, Michio| Watanabe, Akiharu| Nakatsukasa, Harushige| Fujiwara, Masachika| Shiota, Tetsuya| Takei, Nobuyuki| Sakata, Tatsuro| Yamauchi, Yasuhiko| Nagashima, Hideo|
Abstract <p>The prognoses of patients with alcoholic liver cirrhosis were compared between those who continued to drink and those who stopped. Clinical criteria were strictly set so as to control other variables affecting the prognoses. Four-year survival was significantly higher in the patients who stopped drinking than in those who continued to drink. Continued drinking worsens the prognosis of patients with alcoholic liver cirrhosis.</p>
Keywords alcoholic liver cirrhosis prognosis continued drinking stopped drinking alcohol consumption
Amo Type Brief Note
Published Date 1983-12
Publication Title Acta Medica Okayama
Volume volume37
Issue issue6
Publisher Okayama University Medical School
Start Page 525
End Page 527
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6666679
Web of Sience KeyUT A1983RW62800010
JaLCDOI 10.18926/AMO/32401
FullText URL fulltext.pdf
Author Watanabe, Akiharu| Nagashima, Hideo|
Abstract <p>Increased activities of liver glucose-6-phosphate dehydrogenase (G6PD, EC 1.1.1.49) and 6-phosphogluconate dehydrogenase (6PGD, EC 1.1.1.44) in the pentose phosphate cycle were accompanied with a depletion of reduced glutathione (GSH) following an intragastric administration of carbon tetrachloride (CCl4) to rats. Oxidized glutathione (GSSG) also decreased remarkably, keeping the GSSG: GSH ratio constant. No significant alteration of glutathione reductase (EC 1.6.4.2.), glutathione peroxidase (EC 1.11.1.9) and malic enzyme (EC 1.1.1.40) activities in the supernatant and gamma-glutamyl transpeptidase (gamma-GTP, EC 2.3.2.2) activity in the homogenate of the injured liver were observed. Furthermore, no marked difference in the GSH-synthesizing activity was found between control and CCl4-intoxicated liver. An intraperitoneal injection of GSH produced a significant increase in liver GSH content in control rats but not in CCl4-treated rats; G6PD activity was not affected. Intraperitoneal injections of diethylmaleate resulted in continuously diminished levels of liver GSH without any alteration of liver G6PD activity. In vitro disappearance of GSH added to the liver homogenate from CCl4-treated rats occurred enzymatically and could not be prevented by the addition of a NADPH-generating system. The results suggest that increased G6PD activity in CCl4-injured liver does not play an important role in the maintenance of glutathione in the reduced form and that the decreased GSH content in the injured liver might be caused by enhanced GSH catabolism not due to gamma-GTP.</p>
Keywords G6PD glutathione GSH GSSG CCL liver injury diethylmaleate
Amo Type Article
Published Date 1983-12
Publication Title Acta Medica Okayama
Volume volume37
Issue issue6
Publisher Okayama University Medical School
Start Page 463
End Page 470
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6666676
Web of Sience KeyUT A1983RW62800002
JaLCDOI 10.18926/AMO/32395
FullText URL fulltext.pdf
Author Watanabe, Akiharu| Takei, Nobuyuki| Hayashi, Syosaku| Nagashima, Hideo|
Abstract <p>Serum neutral amino acid levels in cirrhotic patients with abnormal oral glucose tolerance test patterns were not different from those of subjects without impaired carbohydrate metabolism. However, the characteristic features of serum aminograms in the patients, that is, increased levels of tyrosine, decreased levels of valine and leucine and the diminished ratio of branched chain amino acids to phenylalanine and tyrosine levels, were less pronounced in those treated with insulin. This finding is clinically important for evaluating the serum aminogram of cirrhotic patients under insulin therapy.</p>
Keywords amino acid cirrhotics carbohydrate metabolism insulin glucose tolerance test
Amo Type Brief Note
Published Date 1983-08
Publication Title Acta Medica Okayama
Volume volume37
Issue issue4
Publisher Okayama University Medical School
Start Page 381
End Page 384
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6353875
Web of Sience KeyUT A1983RE57600011
JaLCDOI 10.18926/AMO/32393
FullText URL fulltext.pdf
Author Watanabe, Akiharu| Shiota, Tetsuya| Okita, Misako| Nagashima, Hideo|
Abstract <p>A new nutritional product (SF-1008C) containing a high proportion of branched chain amino acids (BCAA) and low proportion of aromatic amino acids (AAA) and methionine was tested to see its effect on the impaired protein metabolism and abnormal nutritional state frequently observed in patients with advanced liver cirrhosis. A sharp increase in plasma BCAA levels and fall of AAA and methionine levels were found following the administration of an SF-1008C-supplemented diet to healthy controls and cirrhotic patients, which the BCAA levels increased only slightly following an isocaloric control diet. Blood ammonia levels increased within the normal range transiently following the diets. The SF-1008C-supplemented diet was given for 2 weeks to cirrhotic patients with histories of hepatic encephalopathy, who were taking a low-protein diet because of hyperammonemia. Serum prealbumin levels, nitrogen balance, molar ratio of plasma BCAA/phenylalanine and tyrosine, the number connection test and electroencephalograms improved during the period of the experimental diet. The results, therefore, indicate that a BCAA-supplemented diet is well tolerated by patients with advanced cirrhosis and useful for treatment of impaired protein metabolism. Furthermore, this product is beneficial in preventing hepatic encephalopathy in cirrhotics.</p>
Keywords branched chain amino acid aromatic amino acid nutritional product liver cirrhosis hepatic encephalopathy
Amo Type Article
Published Date 1983-08
Publication Title Acta Medica Okayama
Volume volume37
Issue issue4
Publisher Okayama University Medical School
Start Page 321
End Page 333
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6624532
Web of Sience KeyUT A1983RE57600005
JaLCDOI 10.18926/AMO/32181
FullText URL fulltext.pdf
Author Yasumura, Satoshi| Shimizu, Yukihiro| Yasuyama, Toshifumi| Hiroki, Osamu| Okada, Kazuhiko| Tsukishiro, Takashi| Tsuchida, Toshiriro| Higuchi, Kiyohiro| Watanabe, Akiharu|
Abstract <p>Immune responses to hepatitis B virus (HBV) vaccine in six low- or non-responded health-care workers were tested with an intradermal low dose (5 micrograms) of the recombinant vaccine. The injection was repeated three or four times at fortnightly intervals. These successive doses of the vaccine induced a high concentration of antibodies with delayed-type hypersensitivity (DTH) skin reactions in all six subjects. A few minor temporary side effects, such as irritation and itching at the injection site, were reported by some of the vaccinees. The results suggest low-dose of intradermal HBV vaccinations for low- or non-responders are safe and readily effective.</p>
Keywords skin reaction recombinant HBV vaccine
Amo Type Article
Published Date 1991-12
Publication Title Acta Medica Okayama
Volume volume45
Issue issue6
Publisher Okayama University Medical School
Start Page 457
End Page 459
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1838229
Web of Sience KeyUT A1991GX45300009
JaLCDOI 10.18926/AMO/32093
FullText URL fulltext.pdf
Author Yata, Yutaka| Nakayama, Yoshihide| Takahara, Terumi| Yamazaki, Kunio| Masuyama, Kiichi| Sawataishi, Masaru| Suzuki, Shuichiro| Honma, Masanori| Ishizawa, Shin| Tanaka, Michio| Watanabe, Akiharu| Sugiyama, Toshiro|
Abstract <p>We present a case of a primary advanced gastric tumor that was composed of 2 different pathological components: small cell carcinoma and moderately-differentiated adenocarcinoma. The patient was still alive four years after the surgery was performed, without recurrence. A large part of the tumor consisted of a diffuse sheet of small cell carcinoma, which transitioned into another small portion consisting of moderately-differentiated tubular adenocarcinoma components. Therefore, this case raised the possibility that small cell gastric carcinoma may originate from totipotential stem cells of the stomach. Although small cell carcinoma progresses aggressively, and patients with it have an extremely poor prognosis, this patient recovered uneventfully after the surgical resection, and has remained in good health, without any recurrences.</p>
Keywords gastric tumor small cell carcinoma adenocarcinoma
Amo Type Article
Published Date 2004-12
Publication Title Acta Medica Okayama
Volume volume58
Issue issue6
Publisher Okayama University Medical School
Start Page 275
End Page 278
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 15762296
Web of Sience KeyUT 000225959100004
JaLCDOI 10.18926/AMO/32077
FullText URL fulltext.pdf
Author Watanabe, Akiharu| Hobara, Norio| Tobe, Kazuo| Endo, Hiroshi| Nagashima, Hideo|
Abstract <p>Sprague-Dawley rats given azathioprine in the diet for 3 to 4 weeks developed severe liver damage. Elevations of serum alkaline phosphatase and gamma-glutamyl transpeptidase activities were associated with increased hepatic glucose 6-phosphate dehydrogenase levels and decreased liver glucose 6-phosphatase activities, i.e., conditions which were commonly observed in various hepatotoxin-induced liver injuries. Light and electron microscopic observations revealed centrolobular necrosis with large scars and the proliferation of the mitochondria and rough endoplasmic reticulum. This model could be used to study the mechanisms of azathioprine-induced liver damage and its prevention.</p>
Keywords azathioprine liver injury mechanisms of hepatotoxicity phenobarbital microsomal enzymes
Amo Type Article
Published Date 1979-02
Publication Title Acta Medica Okayama
Volume volume33
Issue issue1
Publisher Okayama University Medical School
Start Page 5
End Page 14
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 220846
JaLCDOI 10.18926/AMO/32066
FullText URL fulltext.pdf
Author Hobara, Norio| Watanabe, Akiharu|
Abstract <p>The disappearance rates(K) of FT-207 from the blood in patients with primary hepatoma and advanced cirrhosis of the liver were significantly lower than those in control patients with cancer but normal liver function. Pretreatment with tocopheryl nicotinate and indomethacin increased the K values in the control subjects, but was without effect on the K values in patients with primary hepatoma.</p>
Keywords FT-207 disappearance rate hepatoma liver cirrhosis tocophery1 nicotinate indomethacin
Amo Type Article
Published Date 1979-10
Publication Title Acta Medica Okayama
Volume volume33
Issue issue5
Publisher Okayama University Medical School
Start Page 389
End Page 393
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 229696
JaLCDOI 10.18926/AMO/32065
FullText URL fulltext.pdf
Author Miyazaki, Masahiro| Watanabe, Akiharu| Syarifuddin, Wahid| Tsunashima, Masakazu| Sato, Jiro|
Abstract <p>Albumin was highly purified from a commercially available rat albumin preparation (Fraction V) using disc electrophoresis. The purified albumin had the same antigenicity as Fraction V. A monospecific anti-rat albumin rabbit serum was obtained. The antiserum was used in a double antibody quantitative method for determining rat albumin.</p>
Keywords rat albumin anti-rat albumin antiserum radioimmunoassay double antibody method
Amo Type Brief Note
Published Date 1979-10
Publication Title Acta Medica Okayama
Volume volume33
Issue issue5
Publisher Okayama University Medical School
Start Page 409
End Page 413
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 160188
JaLCDOI 10.18926/AMO/32047
FullText URL fulltext.pdf
Author Watanabe, Akiharu| Higashi, Toshihiro| Nagashima, Hideo|
Abstract <p>A reproducible animal model of fulminant hepatic failure was developed by intraperitoneal administration of D-galactosamine hydrochloride to Sprague-Dawley rats. Biochemical and morphological hepatic injury and brain edema resembled human fulminant hepatic failure. This model would facilitate further studies of the pathogenesis of brain dysfunction and evaluation of treatment in fulminant hepatic failure.</p>
Keywords fulminant hepatic failure brain edema massive liver injury hepatic encephalopathy
Amo Type Article
Published Date 1979-12
Publication Title Acta Medica Okayama
Volume volume33
Issue issue6
Publisher Okayama University Medical School
Start Page 443
End Page 450
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 161469
NAID 120002311355
JaLCDOI 10.18926/AMO/32038
FullText URL fulltext.pdf
Author Watanabe, Akiharu| Higashi, Toshihiro| Endo, Hiroshi| Nagashima, Hideo|
Abstract <p>Three patients at various stages of remission from leukemia died following the development of massive liver necrosis within only 4-6 days. All had either hepatitis B surface antigen or antibody in their sera, and two of them experienced severe epigastric pain before the onset of liver injury. Hepatitis B surface antigen appeared in two of these patients after remission from leukemia. Serum gamma-globulin levels increased with decreasing doses of prednisolone and other antileukemic drugs, and hepatic cell necrosis occurred extensively. Localization of hepatitis B surface antigen in their livers revealed a strong positive reaction in the phagocytic cells. These observations strongly suggest that hepatitis B virus may be causally related to the fulminant hepatic failure at least in two of the reported leukemic patients.</p>
Keywords fulminant hepatic failure leukemia hepatitis B surface antigen massive liver necrosis immunosuppressive agents
Amo Type Article
Published Date 1979-08
Publication Title Acta Medica Okayama
Volume volume33
Issue issue4
Publisher Okayama University Medical School
Start Page 245
End Page 257
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 158950
JaLCDOI 10.18926/AMO/32003
FullText URL fulltext.pdf
Author Yoshida, Yasuhiro| Higashi, Toshihiro| Nouso, Kazuhiro| Nakatsukasa, Harushige| Nakamura, Shin-ichiro| Watanabe, Akiharu| Tsuji, Takao|
Abstract <p>Hepatic encephalopathy is one of the major complications in decompensated liver cirrhosis. The current study was conducted to clarify the mechanisms of zinc deficiency in liver cirrhosis and its involvement in hepatic encephalopathy via ammonia metabolism. Ten patients each with compensated or decompensated liver cirrhosis and 11 healthy volunteers were enrolled in the study. Serum zinc levels and its daily urinary excretion were measured, an oral zinc-tolerance test was performed to examine zinc malabsorption, and the effects of diuretics on zinc excretion and of zinc supplementation on ammonia metabolism in the skeletal muscle were studied. The mean serum zinc levels in patients with decompensated liver cirrhosis were found to be significantly lower than the levels in controls and patients with compensated liver cirrhosis. The serum zinc levels were inversely correlated with blood ammonia in the fasting state. In the oral zinc-tolerance test, the percent increase in serum zinc levels 120 and 180 min after ingestion was less in cirrhotic patients than in controls. A diuretic administration resulted in a significant reduction in serum zinc levels. An increased uptake of ammonia by and an increased release of glutamine from leg skeletal muscle after oral supplementation of zinc sulfate were evident. Taken together, zinc deficiency in decompensated cirrhotic patients appears to be due to low absorption and to high urinary excretion, for which excessive diuretic administration is, in part, responsible, and zinc supplementation might play an important role in the prevention of hepatic encephalopathy by activating glutamine synthetase.</p>
Keywords zinc ammonia liver cirrhosis hepatic encephalopathy
Amo Type Article
Published Date 2001-12
Publication Title Acta Medica Okayama
Volume volume55
Issue issue6
Publisher Okayama University Medical School
Start Page 349
End Page 355
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11779097
Web of Sience KeyUT 000172838400005
JaLCDOI 10.18926/AMO/31944
FullText URL fulltext.pdf
Author Higashi, Toshihiro| Hashimoto, Makoto| Watanabe, Masatomo| Yamauchi, Yasuhiko| Fujiwara, Masachika| Nakatsukasa, Harushige| Kobayashi, Michio| Watanabe, Akiharu|
Abstract <p>Cathepsin B, H and L activities in small amounts of rat tissue homogenates corresponding to 10 micrograms protein were determined with 7-amino-4-methyl-coumarin conjugates as substrates. A new procedure for serum cathepsin H activity was also developed. High cathepsin B and H activities were found in kidney, spleen and liver. Liver cathepsin B, H and L activities in D-galactosamine-injured rats were decreased concomitantly with an increase in serum cathepsin H activity.</p>
Keywords cathepsin B H and L serum cathepsin H liver injury.
Amo Type Article
Published Date 1986-02
Publication Title Acta Medica Okayama
Volume volume40
Issue issue1
Publisher Okayama University Medical School
Start Page 27
End Page 32
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3962728
Web of Sience KeyUT A1986A190200004
JaLCDOI 10.18926/AMO/31933
FullText URL fulltext.pdf
Author Kobayashi, Michio| Nakatsukasa, Harushige| Watanabe, Akiharu| Yamauchi, Yasuhiko| Fujiwara, Masachika| Hashimoto, Makoto| Watanabe, Masatomo| Higashi, Toshihiro| Nagashima, Hideo|
Abstract <p>&lt;p&gt;Type V collagen-degrading enzyme activity was detected as a metalloprotease acting at neutral pH in the human liver. Type V collagen extracted from human placenta and labeled with [1-14C] acetic anhydride was used as the substrate in the assay. Four major degradation products with relatively high molecular weights were observed upon polyacrylamide gel electrophoresis of the incubation mixture of type V collagen and liver homogenate. The significance of the measurement of this enzyme activity was discussed in relation to the clarification of the mechanism of liver fibrosis.&lt;/p&gt;</p>
Keywords type V collagen-degrading enzyme activity human liver liver fibrosis collagen degradation products
Amo Type Article
Published Date 1986-06
Publication Title Acta Medica Okayama
Volume volume40
Issue issue3
Publisher Okayama University Medical School
Start Page 179
End Page 182
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3017052
Web of Sience KeyUT A1986C914800007
JaLCDOI 10.18926/AMO/31545
FullText URL fulltext.pdf
Author Watanabe, Akiharu| Nakatsukasa, Harushige| Kobayashi, Michio| Nagashima, Hideo|
Abstract <p>Plasma amino acid abnormalities in rats treated with large doses of sake and whisky for 3 days were investigated under adequate nutritional conditions. A significant decrease in plasma branched-chain amino acid (BCAA) levels was observed in sake- but not whisky-treated rats. However, known factors affecting BCAA levels, such as serum insulin and plasma glucagon levels ahd BCAA-metabolizing enzyme (BCAA transaminase and branched chain alpha-ketoacid dehydrogenase) activities in the liver and skeletal muscle, were not significantly altered in the sake group. Furthermore, ethanol-metabolizing enzyme (alcohol and aldehyde dehydrogenases and the microsomal ethanol-oxidizing system) activities in the liver were not altered in the sake group. Other mechanisms need to be considered for explaining the diminished levels of plasma BCAA in sake-treated rats.</p>
Keywords branched chain amino acid alcohol sake whisky insulin glucagon
Amo Type Brief Note
Published Date 1985-02
Publication Title Acta Medica Okayama
Volume volume39
Issue issue1
Publisher Okayama University Medical School
Start Page 67
End Page 71
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 4039101
Web of Sience KeyUT A1985ACS5600008