このエントリーをはてなブックマークに追加
ID 31913
JaLCDOI
FullText URL
Author
Wakiguchi, Hiroshi
Fujieda, Mikiya
Matsumoto, Kenji
Ohara, Yuji
Wakiguchi, Akiko
Shiraishi, Taisuke
Kurashige, Takanobu
Kitamura, Isamu
Abstract

Lymphocyte activation by streptolysin O (SLO) and factors in the plasma which inhibit the response to SLO were examined in 19 patients with mucocutaneous lymphnode syndrome (MCLS), 54 age-matched (6 months-6 years) normal children, 41 normal children older than 6 years and 10 normal adults. In normal children younger than 6 years, the response to SLO was weak and in many cases no response was seen. On the other hand, in the patients with MCLS, the response of lymphocytes to SLO was high and comparable to the response in adults and children older than 6 years. The DNA synthesis of lymphocytes stimulated by SLO was inhibited almost completely by autologous or allogeneic plasma of many of the normal children and adults. The plasma of patients with MCLS did not inhibit, but rather enhanced the response to SLO. These results suggest that the increased response of lymphocytes to SLO and the lack of plasma inhibitory factors in patients with MCLS may be due to the immune response to the pathogen of MCLS, as yet undiscovered.

Keywords
mucocutaneous lymphnode syndrome
streptolysin O
lymphocyte activation
plasma inhibitory factor (s)
Amo Type
Article
Published Date
1986-12
Publication Title
Acta Medica Okayama
Volume
volume40
Issue
issue6
Publisher
Okayama University Medical School
Start Page
285
End Page
289
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT