Author Miyoshi, Shin-ichi| Watanabe, Hirofumi| Kawase, Tomoka| Yamada, Hidenori| Shinoda, Sumio|
Published Date 2004-12
Publication Title Toxicon
Volume volume44
Issue issue8
Content Type Journal Article
Author Watanabe, Hirofumi| Miyoshi, Shin-ichi| Kawase, Tomoka| Tomochika, Ken-ichi| Shinoda, Sumio|
Published Date 2004-3
Publication Title Microbial Pathogenesis
Volume volume36
Issue issue3
Content Type Journal Article
JaLCDOI 10.18926/AMO/31008
FullText URL fulltext.pdf
Author Saito, Daiji| Ueeda, Masayuki| Hina, Kazuyoshi| Watanabe, Hirofumi| Mima, Tsutomu| Hasui, Masahiro| Yamada, Nobuyuki| Haraoka, Shoichi| Tsuji, Takao|
Abstract <p>The effect of the heart rate and myocardial contractile force on the extravascular resistance to blood flow of the left anterior descending coronary artery (LAD) was evaluated in 15 mongrel dogs anesthetized with sodium pentobarbital. The LAD was maximally dilated by intracoronary infusion of adenosine, which precluded the influence of vasomotor tone. Increases in the heart rate and myocardial contractile force decreased coronary blood flow in the absence of a change in coronary perfusion pressure. The changes in mean coronary resistance showed a significant linear relationship to changes in developed tension. The changes in coronary resistance caused by varying the heart rate and contractile force were so small that a normal coronary vascular tree could easily compensate for the increase in resistance. However, it is supposed that with critical stenosis of the vascular tree even a small increase in resistance might cause deleterious effects on coronary blood flow.</p>
Keywords contractile force tachycardia extravascular resistance coronary flow adenosine
Amo Type Article
Published Date 1988-12
Publication Title Acta Medica Okayama
Volume volume42
Issue issue6
Publisher Okayama University Medical School
Start Page 335
End Page 342
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3239438
Web of Sience KeyUT A1988R743300005
JaLCDOI 10.18926/AMO/30893
FullText URL fulltext.pdf
Author Kusachi, Shozo| Iwasaki, Kohichirou| Nishiyama, Osamu| Ueda, Minoru| Kita, Toshimasa| Hata, Takato| Taniguchi, Gyou| Watanabe, Hirofumi| Hina, Kazuyoshi| Saito, Daiji| Tsuji, Takao| Haraoka, Shoichi|
Abstract <p>We studied the factors which may induce acute high grade restenosis in emergency percutaneous transluminal coronary angioplasty (PTCA). PTCA was attempted in 50 patients with acute myocardial infarction, and the balloon catheter passed successfully across the occlusion site in 47 (94%) of the patients. These 47 patients were analyzed. &#34;Acute restenosis&#34; was defined as a lesion which was revascularized to less than 50% luminal reduction narrowed again to more than 75% luminal reduction 5 min after the balloon inflation. Univariate and multivariate analyses were used for determining factors which significantly influenced acute restenosis. The incidence of at least one restenosis episode was 45%. Multiple regression analysis selected 5 factors associated significantly with an increased rate of acute restenosis: 1) angiographic evidence of dissection, 2) lesion in the right coronary artery (RCA), 3) lack of or insufficient administration of thrombolytic agent preceding PTCA, 4) curved lesion and 5) relatively small balloon/artery diameter ratio. Acute restenosis correlated significantly with late reocclusion. This study indicates that it is important to administer a thrombolytic agent prior to emergency PTCA, and to use an adequately sized balloon to the artery when the acute restenosis occurs by using relatively smaller sized balloon. The present data also demonstrated that patients with RCA and a curved lesion have a relatively high risk of acute restenosis. This study indicates how patients with relatively high risk of acute restenosis may be identified.</p>
Keywords emergency coronary angioplasty restenosis acute myocardial infarction multivariate analysis
Amo Type Article
Published Date 1989-02
Publication Title Acta Medica Okayama
Volume volume43
Issue issue1
Publisher Okayama University Medical School
Start Page 55
End Page 63
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 2524153
Web of Sience KeyUT A1989T938500007