JaLCDOI 10.18926/AMO/30400
FullText URL fulltext.pdf
Author Watanabe, Hitoshi| Ogura, Toshio| Hosoya, Masaharu| Nishida, Norikazu| Ota, Zensuke|
Abstract <p>&lt;p&gt;To assess the role of the kidney dopamine system on the diuretic state induced by angiotensin-converting enzyme (ACE) inhibitors, we examined the changes in urinary excretion and plasma level of dopamine, and kidney dopamine receptors in spontaneously hypertensive rats (SHR) treated with cilazapril, an ACE inhibitor. We administered cilazapril 10 mg/kg orally to 13-week-old SHR daily for 21 days (CILAZA group). Systolic blood pressure was significantly decreased in the CILAZA group on Day 6 compared with that in vehicle-treated SHR (control group). The urine volume was three- to fivefold higher in the CILAZA group, and total urinary dopamine secretion was also increased compared with the control group. There was no significant difference in affinity and number of kidney dopamine receptors between the CILAZA and the control groups. In conclusion, the diuretic effect caused by cilazapril is partly mediated by inhibition of the water reabsorption via the increase of dopamine production in the kidney.&lt;/p&gt;</p>
Keywords dopamine ACE inhibitor cilazapril SHR kidney
Amo Type Article
Published Date 1995-10
Publication Title Acta Medica Okayama
Volume volume49
Issue issue5
Publisher Okayama University Medical School
Start Page 247
End Page 252
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8585395
Web of Sience KeyUT A1995TC51800004