JaLCDOI 10.18926/AMO/32033
FullText URL fulltext.pdf
Author Wang, Jiang Ming| Hayashi, Takeshi| Zhang, Wen Ri| Li, Feng| Iwai, Masanori| Abe, Koji|
Abstract <p>In order to investigate a possible effect of insulin-like growth factor-1 (IGF-1) on ischemic brain injury, IGF-1 was applied topically on the brain surface of reperfused rat brain after 60 min of transient middle cerebral artery occlusion. In contrast to the cases treated with vehicle, the infarct volume was greatly reduced at 24 h of reperfusion by the treatment with IGF-1. Immunohistochemical analysis in the middle cerebral artery territory showed that Caspase-3 staining was markedly reduced in the cases with IGF-1 treatment, but 72-kDa heat shock protein staining remained almost unchanged. The present results suggest that treatment with IGF-1 exerts a significant effect on ameliorating brain injury after transient focal brain ischemia. Moreover, this effect is greatly associated with the reduction of Caspase-3 staining, but is only minimally associated with a decreasd stress response at the cellular level.</p>
Keywords caspase-3 cerebra? ischemia 72-KDa heat shock protein
Amo Type Article
Published Date 2001-02
Publication Title Acta Medica Okayama
Volume volume55
Issue issue1
Publisher Okayama University Medical School
Start Page 25
End Page 30
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11246974
Web of Sience KeyUT 000167249900004