JaLCDOI 10.18926/AMO/31724
FullText URL fulltext.pdf
Author Watanabe, Kazuhide| Matsuka, Naoyuki| Okazaki, Masatoshi| Hashimoto, Yasuhiko| Araki, Hiroaki| Gomita, Yutaka|
Abstract <p>The effects of immobilization stress on the pharmacokinetics of omeprazole were studied in rats. The immobilization stress for 30 or 60 min immediately after oral administration of the drug caused an increase in the time to reach the maximum concentration. However, such stress did not alter the area under the plasma concentration-time curve (AUC). When administered intravenously, the half-life during the elimination phase was significantly prolonged by 30 min of immobilization stress, but the AUC value remained unchanged. The intestinal propulsive activity was significantly decreased by immobilization stress. These findings suggest that immobilization stress reduces gastrointestinal motility. A resulting delay during the absorption phase of omeprazole occurs, although the degree of influence on overall pharmacokinetics is relatively insignificant.</p>
Keywords omeprazole pharmacokinetics stress immobilization
Amo Type Article
Published Date 2002-02
Publication Title Acta Medica Okayama
Volume volume56
Issue issue1
Publisher Okayama University Medical School
Start Page 19
End Page 23
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11873940
Web of Sience KeyUT 000174031300004
JaLCDOI 10.18926/AMO/31615
FullText URL fulltext.pdf
Author Araki, Hiroaki| Kawasaki, Machiko| Matsuka, Naoyuki| Nakatsuma, Akira| Watanabe, Kazuhide| Futagami, Koujiro| Gomita, Yutaka|
Abstract <p>The effects of exposure to cigarette smoke on the pharmacokinetics and pharmacodynamics of zonisamide, an antiepileptic drug, were investigated in rats. Absorption of oral zonisamide was significantly inhibited by exposure to cigarette smoke. The Cmax, T1/2 and the area under the plasma concentration-time curve 0-24 values in the cigarette smoke exposure group were significantly lower than those in the control group. Although tonic extension (TE) induced by maximal electroshock was completely blocked by the administration of zonisamide in the control group, 50% of rats showed TE in the cigarette smoke exposure group. Exposure to cigarette smoke influences both the pharmacokinetics and antiepileptic effects of zonisamide. The effects of smoking on epileptic patients using zonisamide warrants further attention.</p>
Keywords cigarette smoking nicotine absorption convulsion zonisamide
Amo Type Article
Published Date 1999-08
Publication Title Acta Medica Okayama
Volume volume53
Issue issue4
Publisher Okayama University Medical School
Start Page 185
End Page 188
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 10488405
Web of Sience KeyUT 000082334300004
JaLCDOI 10.18926/AMO/30470
FullText URL fulltext.pdf
Author Watanabe, Kazuhide| Matsuka, Naoyuki| Furuno, Katushi| Eto, Kohei| Kawasaki, Hiromu| Gomita, Yutaka|
Abstract <p>In order to evaluate a clinical use of omeprazole suspension, we examined the pharmacokinetics of omeprazole after oral administration in rats. Although the administration of omeprazole suspension buffered by NaHCO3 solution did not produce a significant increase in the area under the concentration-time curve (AUC) value compared with non-buffered group, the administration of NaHCO3 buffer immediately after dosing of omeprazole suspension buffered by NaHCO3 caused a significant increase in the AUC value. These results suggest that the NaHCO3 treatment following the administration of omeprazole buffered suspension effectively decreased the degradation of the compound by gastric acid. Therefore, the successive administration of NaHCO3 solution after the omeprazole dosing seems to be a simple and useful method for the administration to patients who cannot receive tablets.</p>
Keywords omeprazole suspension pharmacokinetics rats
Amo Type Article
Published Date 1996-08
Publication Title Acta Medica Okayama
Volume volume50
Issue issue4
Publisher Okayama University Medical School
Start Page 219
End Page 222
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8874584
Web of Sience KeyUT A1996VE60800006
JaLCDOI 10.18926/AMO/30402
FullText URL fulltext.pdf
Author Watanabe, Kazuhide| Eto, Koehi| Furuno, Katsushi| Mori, Takaaki| Kawasaki, Hiromu| Gomita, Yutaka|
Abstract <p>The effect of cigarette smoke on organ weights, lipid peroxidation and plasma biochemical parameters was investigated in male Wistar rats. Daily exposure (for 20 min twice a day) to cigarette smoke for 27 days caused a significant decrease in liver weight and a significant increase in lung weight. The smoke-exposure group showed increased lipid peroxidation in the liver, but not in the lung. In the smoke-exposure group, the GOT, gamma-GTP, total bilirubin and LDH values were significantly higher than those in the control group, while the plasma glucose value was significantly lower. These results suggest that cigarette smoking might induce liver injury by enhancing lipid peroxidation.</p>
Keywords cigarette smoking lipid peroxidation liver function rats
Amo Type Article
Published Date 1995-10
Publication Title Acta Medica Okayama
Volume volume49
Issue issue5
Publisher Okayama University Medical School
Start Page 271
End Page 274
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8585399
Web of Sience KeyUT A1995TC51800008