JaLCDOI 10.18926/AMO/32067
FullText URL fulltext.pdf
Author Watanabe, Makoto| Taketa, Kazuhisa| Fujii, Koukichi| Fujii, Chiaki| Kono, Hiroshi|
Abstract <p>An unusual lipoprotein pattern on polyacrylamide-gel disc-electrophoresis was observed in 37 year-old male diagnosed as alcoholic liver injury. The electrophoretic lipoprotein pattern consisted of a major band of pre-beta mobility and minor intermediate, fast-beta and slow-alpha bands. The normal beta band was virtually absent and the alpha band was diminished. The abnormal lipoprotein pattern was observed one week after discontinuing alcohol consumption when marked hypertriglyceridemia demonstrated earlier had already normalized leaving a moderate hypercholesterolemia with reduced esterified cholesterol and abnormal liver function tests. The lipoprotein abnormalities were completely normal one month later. The appearance of a major pre-beta band with normal triglyceride and high cholesterol levels is discussed in relation to the formation of larger triglyceride-rich LDL particles in recovery from alcoholic hepatitis.</p>
Keywords alcoholic liver injury hyperlipidemia lipoproteins polyacrylamide-gel dise-electrophoresis
Amo Type Article
Published Date 1979-06
Publication Title Acta Medica Okayama
Volume volume33
Issue issue3
Publisher Okayama University Medical School
Start Page 189
End Page 196
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 227229
JaLCDOI 10.18926/AMO/32064
FullText URL fulltext.pdf
Author Watanabe, Makoto|
Abstract <p>The alterations of lipid composition in sera of patients with liver diseases, particularly intrahepatic cholestasis and biliary obstruction, were studied by ultracentrifugation and polyacrylamide-gel disc-electrophoresis of lipoproteins and apoproteins. The elevation of serum cholesterol in intrahepatic cholestasis was greater than in biliary obstruction. The appearance of lipoprotein X in obstructive disease accounted for most of the increased cholesterol. The level of non-lipoprotein X cholesterol in intrahepatic cholestasis was significantly elevated, this being in part ascribed to the appearance of a new class of cholestatic lipoprotein, Slow-migrating HDL. The electrophoretic pattern of lipoprotein in cholestasis was generally characterized by a decrease in alpha band intensity and, in some types of cholestasis, by the appearance of Slow-migrating HDL. In addition, other abnormal lipoproteins exhibiting the characteristics of triglyceride-rich LDL (LP-Y), LP-X-like HDL and LDL-like HDL were found in some cases of intrahepatic cholestasis and biliary obstruction.</p>
Keywords intrahepatic cholestasis primary biliary cirrhosis polyacrylamide-gel disc-electrophoresis high density lipoprotein Slow-migrating HDL(HDL-S)
Amo Type Article
Published Date 1979-10
Publication Title Acta Medica Okayama
Volume volume33
Issue issue5
Publisher Okayama University Medical School
Start Page 269
End Page 285
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 227230
JaLCDOI 10.18926/AMO/32042
FullText URL fulltext.pdf
Author Watanabe, Makoto|
Abstract <p>The alterations of lipid composition in sera of patients with liver diseases, particularly intrahepatic cholestasis and biliary obstruction, were studied by ultracentrifugation and polyacrylamide-gel disc-electrophoresis of lipoproteins and apoproteins. The elevation of serum cholesterol in intrahepatic cholestasis was greater than in biliary obstruction. The appearance of lipoprotein X in obstructive disease accounted for most of the increased cholesterol. The level of non-lipoprotein X cholesterol in intrahepatic cholestasis was significantly elevated, this being in part ascribed to the appearance of a new class of cholestatic lipoprotein, Slow-migrating HDL. The electrophoretic pattern of lipoprotein in cholestasis was generally characterized by a decrease in alpha band intensity and, in some types of cholestasis, by the appearance of Slow-migrating HDL. In addition, other abnormal lipoproteins exhibiting the characteristics of triglyceride-rich LDL (LP-Y), LP-X-like HDL and LDL-like HDL were found in some cases of intrahepatic cholestasis and biliary obstruction.</p>
Keywords intrahepatic cholestasis biliary obstruction cholestatic lipoprotein polyacrylamide-gel disc-electrophoresis ultracentrifugation
Amo Type Article
Published Date 1979-08
Publication Title Acta Medica Okayama
Volume volume33
Issue issue4
Publisher Okayama University Medical School
Start Page 269
End Page 285
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 227230
NAID 120002312295
JaLCDOI 10.18926/AMO/32037
FullText URL fulltext.pdf
Author Watanabe, Makoto| Taketa, Kazuhisa| Nagashima, Hideo| Yamamoto, Yoshio|
Abstract <p>In cardiovascular diseases with potential atherosclerosis, the serum concentration of HDL cholesterol as determined by a precipitation method with dextran sulfate and Mg++ was lower while that of total cholesterol was normal or elevated. Treatment with a daily dose of 1,200 mg of Nicomol, a derivative of nicotinic acid, for 1 to 3 months increased the mean HDL cholesterol level by 3 to 5 mg/dl and reduced the total cholesterol level by 14 to 15 mg/dl and total/HDL cholesterol ratio by 0.8 (3 months) to 0.9 (1 month, p less than 0.05). Similar decreases in HDL cholesterol concentration were also found in parenchymal and obstructive liver diseases with normal total cholesterol values except in fulminant hepatitis and intrahepatic cholestasis.</p>
Keywords HDL cholesterol nicomol atherosclerosis liver diseases
Amo Type Brief Note
Published Date 1979-08
Publication Title Acta Medica Okayama
Volume volume33
Issue issue4
Publisher Okayama University Medical School
Start Page 323
End Page 326
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 227232
JaLCDOI 10.18926/AMO/31266
FullText URL fulltext.pdf
Author Ikeda, Satoru| Nagashima, Hideo| Taketa, Kazuhisa| Watanabe, Makoto|
Abstract <p>Effect of nicomol on high density lipoprotein (HDL) subfractions, HDL2e and HDL3e, separated by electrophoresis.</p>
Keywords HDL<sup>2</sup> HDL<sub>3</sub> HDL cholesterol electrophoresis Nicomol nicotinic acid derivative.
Amo Type Brief Note
Published Date 1981-04
Publication Title Acta Medica Okayama
Volume volume35
Issue issue2
Publisher Okayama University Medical School
Start Page 149
End Page 154
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6456646
Web of Sience KeyUT A1981LS45700008
Author Watanabe, Makoto| Yuasa, Shiro| Taketa, Kazuhisa| Konaga, Eiji| Okajima, Kunio|
Published Date 1978-04
Publication Title Acta Medica Okayama
Volume volume32
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/30942
FullText URL fulltext.pdf
Author Takasaki, Yohsuke| Kawakami, Norito| Tsuchiya, Masao| Ono, Yutaka| Nakane, Yoshibumi| Nakamura, Yosikazu| Tachimori, Hisateru| Iwata, Noboru| Uda, Hidenori| Nakane, Hideyuki| Watanabe, Makoto| Naganuma, Yoichi| Furukawa, Toshiaki| Hata, Yukihiro| Kobayashi, Masayo| Miyake, Yuko| Takeshima, Tadashi| Kikkawa, Takehiko|
Abstract <p>We examined whether selected circulatory diseases (heart disease, stroke, diabetes and hypertension) were associated with an increased risk of major depression in the Japanese community population. Face-to-face household surveys were carried out in 7 areas, and a total of 2,436 persons participated (overall response rate: 58.4%) from 2002 to 2004. The WHO Composite International Diagnostic Interview 3.0 was used to diagnose major depression according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, and additional interviews assessed the presence of circulatory diseases. Using data from a random subsample of the respondents (n=832), we conducted Cox proportional hazards models to calculate hazard ratios for the onset of major depression with comorbid circulatory diseases as a time-dependent covariate. Heart attack was significantly associated with the onset of major depression (hazard ratio [HR], 7.51 [95%Confidential Interval (CI), 1.36-41.45]) after adjusting for sex, birth cohort, smoking, alcohol intake, and education. Heart disease (HR, 2.12 [95% CI, 0.79-5.70]), diabetes (HR, 2.36 [95% CI, 0.42-13.34]) and hypertension (HR, 0.97 [95% CI, 0.37, 2.50]) were not significantly associated. There were no subjects who developed major depression after stroke. These results suggest that heart attack, and maybe also heart disease and diabetes, affect the onset of major depression.</p>
Keywords heart disease circulatory diseases major depression community residents world mental health
Amo Type Original Article
Published Date 2008-08
Publication Title Acta Medica Okayama
Volume volume62
Issue issue4
Publisher Okayama University Medical School
Start Page 241
End Page 249
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 18596830
Web of Sience KeyUT 000258680900004
JaLCDOI 10.18926/AMO/30548
FullText URL fulltext.pdf
Author Ide, Takero| Taketa, Kazuhisa| Watanabe, Makoto| Ikeda, Satoru| Izumi, Masaki| Sokabe, Teruko| Kono, Hiroshi| Yamamoto, Yoshio|
Abstract <p>&lt;p&gt;The levels of HDL-cholesterol and gamma-glutamyltransferase in the sera of 17 patients with alcoholic liver injury were followed after abstinence and compared with those of 11 patients with acute non-alcoholic hepatitis. The activity of gamma-glutamyltransferase decreased in all cases irrespective of the type of liver injuries. The level of HDL-cholesterol also decreased in 11 of 17 cases with alcoholic liver injury. The other alcoholics, in whom HDL-cholesterol level increased or showed no definite change after withdrawal of alcohol, had severe and advanced liver injuries. In non-alcoholic hepatitis, the HDL-cholesterol level increased as normal liver functions were restored except for one case with cholestatic features. It was concluded that alcohol intake can increase HDL-cholesterol level even in the presence of a concomitantly induced hepatic lesion.&lt;/p&gt;</p>
Keywords alcoholic liver injury HDL-cholesterol ?-glutamy1-transferase.
Amo Type Article
Published Date 1980-11
Publication Title Acta Medica Okayama
Volume volume34
Issue issue5
Publisher Okayama University Medical School
Start Page 293
End Page 299
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6108050
Web of Sience KeyUT A1980KT96800001