JaLCDOI 10.18926/AMO/52791
FullText URL 68_4_249.pdf
Author Ogawara, Yuya| Tachibana, Tomoyasu| Orita, Yorihisa| Uchino, Kaori| Wani, Yoji| Nagahiro, Itaru| Matsuyama, Yuko| Abe, Iku| Fujisawa, Masayoshi| Nishizaki, Kazunori|
Abstract We describe an extremely rare case of tracheal stenosis caused by unnoticed microscopic fiber-like foreign bodies. A 66-year-old woman complained of dyspnea with inspiratory stridor. Magnifying electroendoscopy and computed tomography revealed stenosis involving the entire circumference of the tracheal lumen. Tracheotomy and biopsy were performed. Histologically, the lesion showed chronic inflammation with a deposition of fiber-like foreign bodies. The patient had no history of trauma or inhalation injury, but had undergone intratracheal intubation on 4 occasions. The lesion was incised using semiconductor laser photoresection, and the postoperative course was good. To the best of our knowledge, this represents the first report in the English literature of tracheal stenosis caused by unnoticed foreign bodies. The origin of these fiber-like foreign bodies remains unclear but might be related to chronic inflammation resulting from intratracheal intubations.
Keywords tracheal stenosis fibrous foreign body intubation tracheotomy laser
Amo Type Case Report
Published Date 2014-08
Publication Title Acta Medica Okayama
Volume volume68
Issue issue4
Publisher Okayama University Medical School
Start Page 249
End Page 252
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25145411
Web of Sience KeyUT 000340687500007
JaLCDOI 10.18926/AMO/32006
FullText URL fulltext.pdf
Author Wani, Yoji| Notohara, Kenji| Tsukayama, Choutatsu| Okada, Shigeru|
Abstract <p>We performed an immunohistochemical analysis of 2 major DNA mismatch repair proteins, human Mut L homologue-1 (hMLH1) and human Mut S homologue-2 (hMSH2), in hepatocellular carcinoma (HCC) using 33 biopsied and 58 surgically resected specimens, as well as 30 samples from non-cancerous livers. In well-differentiated HCCs, the immunoreactivity for these antigens was well preserved, and the staining intensity was stronger compared to the surrounding liver tissues. However, among 41 moderately-differentiated and 9 poorly-differentiated HCCs of the resected cases, hMLH1- and hMSH2-positive cells were significantly reduced in 19 (38%) and 9 (18%) cases, respectively. In 9 resected tumors, the expression of both of these antigens was reduced. Moreover, in 41 tumors of differing histological grades, 10 and 5 tumors for hMLH1 and hMSH2, respectively, contained a less-differentiated area with a reduced number of immunoreactive cells. The samples from non-cancerous biopsied liver and fetal autopsy tissue were well immunostained for both hMLH1 and hMSH2. We confirmed in this series that the hMLH1 and hMSH2 defect did commonly occur in high-grade HCCs, and that it might play a role in tumor progression.</p>
Keywords hepatocellular carcinoma human Mut L homologue-1(hMLH1) human Mut S homologue-2(hMS2) mismatch repair proteins immunohistochemistry
Amo Type Article
Published Date 2001-04
Publication Title Acta Medica Okayama
Volume volume55
Issue issue2
Publisher Okayama University Medical School
Start Page 65
End Page 71
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11332201
Web of Sience KeyUT 000168195700002