JaLCDOI 10.18926/AMO/30448
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Author Haruta, Yuro| Takahashi, Isao| Sekito, Noriko| Miyamoto, Kanji| Shimamoto, Masaaki| Wakita, Yoshiharu| Kikkawa, Kiyoshi| Nakamura, Toru| Seto, Takumi| Yamashita, Jiro| Yorimiysu, Seiichi| Miyake, Susumu| Machida, Ken-ichi| Kimura, Ikuro|
Abstract <p>A rare case of variant Philadelphia (Ph1) chromosome positive [46, XX, t (9; 22) (q34; q11), inv (9) (9q22; 22q13)] chronic myelocytic leukemia (CML) was described. The patient, 73 years old female, was hospitalized to our hospital because of leukocytosis. Hematological findings corresponded to those of CMLs. However, this case lacked hepatosplenomegaly. Southern blot analysis using a 3 breakpoint cluster region (bcr) probe revealed a bcr rearrangement. The patient has been in the chronic phase for sixteen months without treatment. Clinical and chromosomal changes are under observation in order to get accumulate data for a pathophysiological analysis of variant Ph1 positive CMLs.</p>
Keywords variant Ph1 positive chronic myelocytic leukemia bcr rearrangement
Amo Type Article
Published Date 1990-10
Publication Title Acta Medica Okayama
Volume volume44
Issue issue5
Publisher Okayama University Medical School
Start Page 283
End Page 286
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 2260501
Web of Sience KeyUT A1990EG00700009
JaLCDOI 10.18926/AMO/31025
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Author Wakita, Yoshiharu| Narahara, Kouji| Kimoto, Hiroshi|
Abstract <p>We studied the dermatoglyphics of 353 severe mental retardates (excluding those with chromosomal abnormalities and major limb malformations), using multivariate analysis, to determine how early intrauterine factors are related to the etiology of mental retardation. First, dermatoglyphics were compared between 140 individuals with undefined prenatal factors and 700 normal controls. After 6 and 9 dermatoglyphic traits were chosen as discriminative variables for males and females, respectively, the data were subjected separately for each sex to the constellation graphical method for discriminant analysis. The same formula as obtained in the idiopathic group was subsequently applied to data from cases in other etiological categories. When the misclassification rate was 0.03, the rates of correct classification of the male patients into the etiological categories of undefined prenatal, defined prenatal, perinatal, postnatal and unknown (no anamnestic data available) categories were 19.7% (13/66), 20.0% (3/15), 8.8% (5/57), 5.0% (1/20) and 7.7% (2/26), while the correct classification rates of females were 24.3% (18/74), 42.1% (8/19), 18.9% (7/37), 5.1% (1/16) and 13.0% (3/23), respectively. The results suggest that early intrauterine factors such as those producing dermatoglyphic deviations may contribute to the pathogenesis of severe mental retardation not only in patients with undefined prenatal etiological factors but also in those with perinatal factors, especially those of the female sex.</p>
Keywords mental retardation dermatoglyphics multivariate analysis constellation graphical method
Amo Type Article
Published Date 1988-06
Publication Title Acta Medica Okayama
Volume volume42
Issue issue3
Publisher Okayama University Medical School
Start Page 159
End Page 168
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3400482
Web of Sience KeyUT A1988P034000006