JaLCDOI 10.18926/AMO/56655
FullText URL 73_2_181.pdf
Author Okamura, Tomoka| Washio, Yousuke| Yoshimoto, Junko| Tani, Kazumasa| Tsukahara, Hirokazu| Shimada, Akira|
Abstract Most cases of transient abnormal myelopoiesis (TAM) in neonates with Down syndrome (DS) resolve spontaneously; however, DS-TAM neonates with hydrops fetalis (HF) show poor clinical outcomes. We report three infants with DS-TAM and HF who were treated with exchange transfusion (ET) followed by low-dose cytarabine (LD-CA). All of them survived without developing liver failure, acute leukemia, or other serious adverse events. Our results suggest that this combination treatment with ET and LD-CA would be safe, tolerable and effective as an novel approach for DS-TAM patients with HF.
Keywords cytarabine Down syndrome exchange transfusion hydrops fetalis transient abnormal myelopoiesis
Amo Type Case Report
Published Date 2019-04
Publication Title Acta Medica Okayama
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 181
End Page 188
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015754