JaLCDOI 10.18926/AMO/55311
FullText URL 71_4_341.pdf
Author Yamazaki, Kenji| Wakabayashi, Hiroshi| Suganami, Yu| Sano, Shinichi| Wakunami, Yu| Katayama, Takashi| Deguchi, Kentaro| Nagotani, Shoko| Kishida, Masayuki|
Abstract We report a case of a woman with typical dermatomyositis (DM) with skin manifestations, severe myalgia and muscle weakness complicated by interstitial lung disease (ILD) and pneumomediastinum. Pneumomediastinum persisted despite treatment with immunosuppressive therapy (steroids and cyclosporine). After the test for anti-melanoma differentiation-associated gene 5 (MDA5) antibody came out positive, we doubled the cyclosporine dose and her condition improved. Despite typical clinical features of DM, in cases complicated by pneumomediastinum or steroid resistance, measurement of anti-MDA5 antibody may be useful for immunosuppressant dose titration.
Keywords dermatomyositis anti-melanoma differentiation-associated gene 5 antibody interstitial lung disease pneumomediastinum
Amo Type Case Report
Published Date 2017-08
Publication Title Acta Medica Okayama
Volume volume71
Issue issue4
Publisher Okayama University Medical School
Start Page 341
End Page 344
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28824190