このエントリーをはてなブックマークに追加
ID 30797
JaLCDOI
FullText URL
Author
Seymen, Oktay
Seven, Arzu
Candan, Gulden
Yigit, Gunnur
Hatemi, Sezer
Hatemi, Husrev
Abstract

Our aim was to study the effect of iron supplementation on the following aspects of erythrocyte metabolism in experimental hyperthyroidism: glutathione (GSH) levels, glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) activities. Hyperthyroidism induced by L-thyroxine administrations significantly raised erythrocyte GSH, GSH-Px and SOD levels of the rats (P < 0.001). Likewise, we observed that iron supplementation induced significant rises in erythrocyte GSH, GSH-Px and SOD levels (P < 0.001) as compared with the control group. The erythrocyte GSH, GSH-Px and SOD levels of hyperthyroidism-induced iron-supplemented animals were significantly higher when compared with either the iron-supplemented group (P < 0.001) or the only L-thyroxine-administered hyperthyroid group (P < 0.001, P < 0.05, P < 0.01, respectively). The results of this study show that L-thyroxine administration and/or iron supplementation increases GSH, GSH-Px and SOD levels of erythrocytes.

Keywords
iron
hyperthyroidism
glutathione
superoxide dismutase
glutathione peroxidase
Amo Type
Article
Published Date
1997-06
Publication Title
Acta Medica Okayama
Volume
volume51
Issue
issue3
Publisher
Okayama University Medical School
Start Page
129
End Page
133
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT