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ID 32033
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Author
Wang, Jiang Ming
Hayashi, Takeshi
Zhang, Wen Ri
Li, Feng
Iwai, Masanori
Abstract

In order to investigate a possible effect of insulin-like growth factor-1 (IGF-1) on ischemic brain injury, IGF-1 was applied topically on the brain surface of reperfused rat brain after 60 min of transient middle cerebral artery occlusion. In contrast to the cases treated with vehicle, the infarct volume was greatly reduced at 24 h of reperfusion by the treatment with IGF-1. Immunohistochemical analysis in the middle cerebral artery territory showed that Caspase-3 staining was markedly reduced in the cases with IGF-1 treatment, but 72-kDa heat shock protein staining remained almost unchanged. The present results suggest that treatment with IGF-1 exerts a significant effect on ameliorating brain injury after transient focal brain ischemia. Moreover, this effect is greatly associated with the reduction of Caspase-3 staining, but is only minimally associated with a decreasd stress response at the cellular level.

Keywords
caspase-3
cerebra? ischemia
72-KDa heat shock protein
Amo Type
Article
Published Date
2001-02
Publication Title
Acta Medica Okayama
Volume
volume55
Issue
issue1
Publisher
Okayama University Medical School
Start Page
25
End Page
30
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT