start-ver=1.4
cd-journal=joma
no-vol=2012
cd-vols=
no-issue=
article-no=
start-page=11
end-page=11
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2012
dt-pub=20120209
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Activation of Biodefense System by Low-Dose Irradiation or Radon Inhalation and Its Applicable Possibility for Treatment of Diabetes and Hepatopathy
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Adequate oxygen stress induced by low-dose irradiation activates biodefense system, such as induction of the synthesis of superoxide dismutase (SOD) and glutathione peroxidase. We studied the possibility for alleviation of oxidative damage, such as diabetes and nonalcoholic liver disease. Results show that low-dose ƒÁ-irradiation increases SOD activity and protects against alloxan diabetes. Prior or post-low-dose X- or ƒÁ-irradiation increases antioxidative functions in livers and inhibits ferric nitrilotriacetate and carbon tetrachloride-induced (CCl<sub>4</sub>) hepatopathy. Moreover, radon inhalation also inhibits CCl<sub>4</sub>-induced hepatopathy. It is highly possible that low-dose irradiation including radon inhalation activates the biodefence systems and, therefore, contributes to preventing or reducing reactive oxygen species-related diabetes and nonalcoholic liver disease, which are thought to involve peroxidation.
en-copyright=
kn-copyright=

en-aut-name=KataokaTakahiro
en-aut-sei=Kataoka
en-aut-mei=Takahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=YamaokaKiyonori
en-aut-sei=Yamaoka
en-aut-mei=Kiyonori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University

affil-num=2
en-affil=
kn-affil=Graduate School of Health Sciences, Okayama University
END