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ID 52860
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Author
Zou, Yu
Wang, Da-Hong
Iwanaga, Suketaka
Taketa, Kazuhisa
Inoue, Kiyomi
Abstract
Retinol, alpha-tocopherol, and gamma-tocopherol are fat-soluble vitamins acting as antioxidants via the prevention of lipid oxidation. Little is known about circulatory levels in healthy individuals. The present cross-sectional study aimed at elucidating the relationship between these antioxidants and clinical biomarkers in 206 male (median age 41 years, range 23-67) employees from companies located in the Okayama Prefecture, Japan. Subjects younger than 40 years (n = 94) showed a positive association of the frequency of alcohol consumption with the circulating retinol (beta = 0.344, p = 0.001) and gamma-tocopherol levels (beta = 0.219, p = 0.041), and an inverse association of fast insulin with serum retinol (beta = -0.301, p = 0.009). In participants older than 40 years (n = 112) we found that an inverse association of HOMA-R with serum retinol (beta = -0.262, p = 0.021), a-tocopherol (beta = -0.236, p = 0.035), and gamma-tocopherol levels (beta = -0.224, p = 0.052); and cigarette smoking was inversely associated with the levels of serum a-tocopherol (beta = -0.286, p = 0.008) and gamma-tocopherol (beta = -0.229, p = 0.040). We further found negative relationships between serum ferritin and the retinol (beta = -0.211, p = 0.032) and a-tocopherol levels (beta = -0.223, p = 0.022) in men over 40 years of age. The present study suggests that the circulatory levels of antioxidant vitamins may modulate the action of insulin and that higher levels of iron might decrease the levels of antioxidant vitamins in the blood.
Keywords
serum retinol
serum alpha-tocopherol
serum gamma-tocopherol
HOMA-R
serum ferritin
smoking
alcohol consumption
Published Date
2014-02
Publication Title
International Journal of Environmental Research and Public Health
Volume
volume11
Issue
issue2
Start Page
1647
End Page
1660
ISSN
1660-4601
Content Type
Journal Article
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/52831
language
英語
Copyright Holders
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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publisher
Refereed
True
DOI
Web of Sience KeyUT