start-ver=1.4
cd-journal=joma
no-vol=110
cd-vols=
no-issue=1-6
article-no=
start-page=61
end-page=69
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=19980625
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=第134回　岡山外科会
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=山崎泰弘
kn-aut-sei=山崎
kn-aut-mei=泰弘
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=110
cd-vols=
no-issue=1-6
article-no=
start-page=53
end-page=60
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=19980625
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Sugar chain alterations of glycoproteins in spent culture media of human hepatocellular carcinoma cell lines analyzed by lectin-affinity electrophoresis
kn-title=レクチン親和電気泳動を用いた肝癌細胞株培養液上清中の糖蛋白糖鎖変異に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Sugar chain alterations of α-fetoptotein (AFP),α1-Antitrypsin (AAT) and transferrin (Tf) in spent culture media of human hepatoma cell lines, HuH-7, huH-1, Hep-G2 and KIM-1, were analyzed by lectin-affinity electrophoresis with Concanavalin A (Con A), Lens culinaris agglutinin (LCA) and Phaseolus vulgaris lectin (E4-PHA) and antibody-affinty blotting. Their glycoforms demonstrated lectin-dependent characteristic patterns similar to the glycoforms of AFP in hepatocellular carcinomas, although their separation became less chear as the number of sugar chains per molecule increased. The proportions of band intensities of the glycoform of AAT and Tf corresponding to AFP-C1, AFP-L3 and AFP-P4 increased consistently in all cell lines. However, the extent of the increases in the glycoforms differed from one cell line to another, reflecting tumor heterogenity. On the other hand, the sugar chain alterations of glycoproteins were similar in each cell line, although the glycoforms separated with Con A showed slightly different patterns from those separated with LCA. Accordingly, hepatocelluler carcinoma may be detected at an early stage by analyzing the glycoforms of serum AAT and Tf by lectin-affinity electrophoresis for cases with negative AFP.
en-copyright=
kn-copyright=

en-aut-name=FukazawaMasako
en-aut-sei=Fukazawa
en-aut-mei=Masako
kn-aut-name=深澤真子
kn-aut-sei=深澤
kn-aut-mei=真子
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部公衆衛生学教室
en-keyword=Glycoprotein
kn-keyword=Glycoprotein
en-keyword=lectin affinity electrophoresis
kn-keyword=lectin affinity electrophoresis
en-keyword=cultured hepatoma cell line
kn-keyword=cultured hepatoma cell line
END

start-ver=1.4
cd-journal=joma
no-vol=110
cd-vols=
no-issue=1-6
article-no=
start-page=39
end-page=51
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=19980625
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Analysis of ictal EEGs in West syndrome
kn-title=West 症候群の発作時脳波に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Although tonic spasms (TS) observed in West syndrome(WS) are regarded as generalized seizures, the mechanism of their occurrence has not yet been fully elucidated. We analyzed ictal EEGs of TS to determine the mechanism and to clarify the role of cortical pathology in the occurrence of TS. Of 53 infants with WS, we classified cryptogenic cases as Group �T. Symptomatic cases were classified into 2 groups : Group �U consisted of those without partial seizures during the period of WS and Group 3 consisted of those with partial seizures. We analyzed 7283 ictal EEGs of TS regarding the following 5 points : 1) patterns of ictal EEGs, 2) frequency of isolated TS, 3) asymmetry of ictal EEGs, 4) spasm-spasm intervals, and 5) duration of ictal EEGs of each TS. We concluded that the asymmetry of ictal EEGs and the "rhythmic slow activity" immediately following ictal EEGs of TS were related to cortical pathology. Since "rhythmic slow activities" were often observed in Group �V and appeared at the same regions as those in ictal EEGs of concomittant partial seizures, they were considered to be peculiar EEG patterns related to cortical pathologic lesions.
en-copyright=
kn-copyright=

en-aut-name=AsanoTakashi
en-aut-sei=Asano
en-aut-mei=Takashi
kn-aut-name=浅野孝
kn-aut-sei=浅野
kn-aut-mei=孝
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部小児神経学講座
en-keyword=West 症候群
kn-keyword=West 症候群
en-keyword=発作時脳波
kn-keyword=発作時脳波
en-keyword=Tonic spasms
kn-keyword=Tonic spasms
en-keyword=部分発作
kn-keyword=部分発作
END

start-ver=1.4
cd-journal=joma
no-vol=110
cd-vols=
no-issue=1-6
article-no=
start-page=31
end-page=37
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=19980625
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=2β-(3-Hydroxypropoxy)1α,25-Dihydroxyvitamin D(3)(ED-71), increases bone mass by stimulating bone formation in hypophosphatemic mice
kn-title=活性型ビタミンD(3)誘導体である2β-(3-hydroxypropoxy)-1α,25(OH)(2)D(3)(ED-71)による骨密度増加作用―hypophosphatemic マウスにおける検討―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=To determine the effects of ED-71, a new active vitamin D3 analogue, on bone, we examined the action of ED-71 and 1α,25(OH)(2)D(3), using hypophosphatemic (Hyp) mice, a model for X-linked hypophosphatemic rickets in humans. ED-71 has the unique characteristics of a longer half-life in serum, a higher binding affinity to serum vitamin D binding protein and lower affinity to the vitamin D receptor than 1α,25(OH)(2)D(3). Hyp mice were treated with 10-1200
pmol/kg/day of ED-71, 40-400 pmol/kg/day of 1α,25(OH)(2)D(3), or the vehicle alone, administered daily for 21 days by subcutaneous injection. ED-71 at doses of 100-400 pmol/kg/day, dose-dependently effects in increased bone size and bone mineral density (BMD) without causing hypercalcemia. However 1α,25(OH)(2)D(3) at a dose of 400 pmol/kg/day, demonstrated only slight increases in bone size and BMD with hypercalcemia. These findings suggest that ED-71 may be more beneficial in the treatment of X-linked hypophosphatemic rickets than 1α,25(OH)(2)D(3).
en-copyright=
kn-copyright=

en-aut-name=OchiHideaki
en-aut-sei=Ochi
en-aut-mei=Hideaki
kn-aut-name=越智英明
kn-aut-sei=越智
kn-aut-mei=英明
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部小児科学講座
en-keyword=ED-71
kn-keyword=ED-71
en-keyword=Hyp mouse
kn-keyword=Hyp mouse
en-keyword=BMD
kn-keyword=BMD
en-keyword=Ca
kn-keyword=Ca
END

start-ver=1.4
cd-journal=joma
no-vol=110
cd-vols=
no-issue=1-6
article-no=
start-page=21
end-page=29
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=19980625
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental study on the maintenance of hepatic circulation with arterial blood through a catheter bypass during total vascular clamping at the hepatic hilus
kn-title=肝十二指腸間膜遮断下門脈内動脈血送血の安全域に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=This study was designed to determine the safe range of the arterial blood flow rate into the portal vein through a catheter bypass under the condition of total vascular clamping at the hepatic hilus in mongrel dogs. A control group and 6 experimental groups were prepared according to the arterial blood flow rates through the bypass, 0, 10, 25, 50, 75 and 100% of the normal total hepatic blood flow volume. After 2 hours of bypass circulation, the dogs were sacrificed and the hepatic tissues of all groups were examined by light microscopy and transmission electron microscopy. Compared with the control group, ischemic changes were observed in the 0% and 10% groups, while there were no particular changes in the other groups. Edema in the Glisson's sheath was observed in the 75% and 100% groups, while there was no edema in the other groups. The  results demonstrated that the lower limit of the arterial blood flow rate through a catheter bypass to mantain the hepatic structure was between 10% and 25% and the higher limit was between 50% and 75% of the normal total hepatic blood flow volume.
en-copyright=
kn-copyright=

en-aut-name=MoriTakashi
en-aut-sei=Mori
en-aut-mei=Takashi
kn-aut-name=森隆
kn-aut-sei=森
kn-aut-mei=隆
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部外科学第一講座
en-keyword=double catheter bypass of portal circulation
kn-keyword=double catheter bypass of portal circulation
en-keyword=arterialization of the portal vein
kn-keyword=arterialization of the portal vein
en-keyword=hepatic ischemia
kn-keyword=hepatic ischemia
en-keyword=en block resection of the hepatoduodenal ligament
kn-keyword=en block resection of the hepatoduodenal ligament
END

start-ver=1.4
cd-journal=joma
no-vol=110
cd-vols=
no-issue=1-6
article-no=
start-page=9
end-page=20
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=19980625
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Localization of Mn- and  Cu/Zn-SOD-like immunoreactive cells in the rat brain
kn-title=Mn-SOD および Cu/Zn-SOD 様免疫組織化学反応陽性細胞のラット脳内分布
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The localization of manganese (Mn) and copper-zinc (Cu/Zn) superoxide dismutase (SOD)-like immunoreactive (lir) cells in the normal rat brain and the change in numbers of both SOD-lir cortical cells after the injection of ferric chloride into the sensorimotor cortex were investigated immunohistochemically. Large and medium-sized cell bodies, pyramidal to polygonal in shape, were immunostained by anti-Mn-SOD antibody. Most of these were not immunolabeled by anti-GFAP antibody, suggesting that most of the Mn-SOD-lir cells are neurons. These cell bodies were distributed in some selected brain areas with different densities. The densest population of Mn-SOD-lir cells was found in the hypothalamic and limbic structures, and in some brain stem nuclei, such as the thalamic reticular nucleus, the locus ceruleus and the pontine nucleus. Anti-Cu/Zn-SOD antibody immunostained many small round cells throughout both white and gray matter, most of which were also immunolabeled by anti-GFAP antiserum. After intacortical injection of FeCl3, the numbers of Mn- and Cu/Zn-SOD-lir cells per unit area within the adjacent narrow region of the injection site significantly increased 2 and 6 hr after the injection, respectively.
en-copyright=
kn-copyright=

en-aut-name=WangYan
en-aut-sei=Wang
en-aut-mei=Yan
kn-aut-name=王燕
kn-aut-sei=王
kn-aut-mei=燕
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部解剖学第三講座
en-keyword=Mn-SOD
kn-keyword=Mn-SOD
en-keyword=Cu/Zn-SOD
kn-keyword=Cu/Zn-SOD
en-keyword=免疫組織化学
kn-keyword=免疫組織化学
en-keyword=ラット脳内分布
kn-keyword=ラット脳内分布
en-keyword=FeCl3　大脳皮質内注入
kn-keyword=FeCl3　大脳皮質内注入
END

start-ver=1.4
cd-journal=joma
no-vol=110
cd-vols=
no-issue=1-6
article-no=
start-page=1
end-page=8
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1998
dt-pub=19980625
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=A case of living related liver transplantation for an adult recipient with primary biliary cirrhosis
kn-title=原発性胆汁性肝硬変に対する成人生体部分肝移植の1例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A 49-year-old female received a living related liver transplantation from her son. She had a 13-years history of primary biliary cirrhosis (PBC). The preoperative 1-year survival rate and mortality after 6 months were calculated to be 6.5% and 99.3%, respectively. The graft included left bisegments weighing 435g, and was equal to 43% of the calculated standard liver volume. Massive ascites were sustained due to accompanied portal hypertension. On Postoperative day 7, she manifested massive tarry stool by portal-hypertensive colonopathy. The CT scan revealed a right subphrenic abscess on the postoparative day 14. After drainage of the abscess, the serum total billirubin level decreased to the norman range. She was descharged with extracorptreal tube dainage. On the postoperative day 169, she was readmitted due to acute elevation of the serum bilirubin level. Echography revealed selective dilatation of the hepatic bile duct in the segment 2, and suggested the presence of insufficiency of hepatico-jejunostomy in the early postoperative phase. Despite emergent PTCD, jaundice was sustained and responded poorly to steroid pulse therapy. According to tapering of oral prednisolone, the serum bilirubin level gradually decreased and reached a the plateau between 2 and 4mg/dl. The patient is currently completely free from oral steroid therapy and in receiving interventional hepaticoplasty using the YAG laser system. We concluded that living related liver transplantation is an effective transplantational option for adult end-stage liver disease.
en-copyright=
kn-copyright=

en-aut-name=YagiTakahito
en-aut-sei=Yagi
en-aut-mei=Takahito
kn-aut-name=八木孝仁
kn-aut-sei=八木
kn-aut-mei=孝仁
aut-affil-num=1
ORCID=

en-aut-name=UrushiharaNaoto
en-aut-sei=Urushihara
en-aut-mei=Naoto
kn-aut-name=漆原直人
kn-aut-sei=漆原
kn-aut-mei=直人
aut-affil-num=2
ORCID=

en-aut-name=OishiMasahiro
en-aut-sei=Oishi
en-aut-mei=Masahiro
kn-aut-name=大石正博
kn-aut-sei=大石
kn-aut-mei=正博
aut-affil-num=3
ORCID=

en-aut-name=MatsukawaHiroyoshi
en-aut-sei=Matsukawa
en-aut-mei=Hiroyoshi
kn-aut-name=松川啓義
kn-aut-sei=松川
kn-aut-mei=啓義
aut-affil-num=4
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=藤原俊哉
kn-aut-sei=藤原
kn-aut-mei=俊哉
aut-affil-num=5
ORCID=

en-aut-name=
en-aut-sei=
en-aut-mei=
kn-aut-name=松野剛
kn-aut-sei=松野
kn-aut-mei=剛
aut-affil-num=6
ORCID=

en-aut-name=MoriMasanobu
en-aut-sei=Mori
en-aut-mei=Masanobu
kn-aut-name=森雅信
kn-aut-sei=森
kn-aut-mei=雅信
aut-affil-num=7
ORCID=

en-aut-name=TsugeHiromu
en-aut-sei=Tsuge
en-aut-mei=Hiromu
kn-aut-name=津下宏
kn-aut-sei=津下
kn-aut-mei=宏
aut-affil-num=8
ORCID=

en-aut-name=TakakuraNorihisa
en-aut-sei=Takakura
en-aut-mei=Norihisa
kn-aut-name=高倉範尚
kn-aut-sei=高倉
kn-aut-mei=範尚
aut-affil-num=9
ORCID=

en-aut-name=TanakaNoriaki
en-aut-sei=Tanaka
en-aut-mei=Noriaki
kn-aut-name=田中紀章
kn-aut-sei=田中
kn-aut-mei=紀章
aut-affil-num=10
ORCID=

en-aut-name=HigashiToshihiro
en-aut-sei=Higashi
en-aut-mei=Toshihiro
kn-aut-name=東俊宏
kn-aut-sei=東
kn-aut-mei=俊宏
aut-affil-num=11
ORCID=

en-aut-name=TsujiTakao
en-aut-sei=Tsuji
en-aut-mei=Takao
kn-aut-name=辻孝夫
kn-aut-sei=辻
kn-aut-mei=孝夫
aut-affil-num=12
ORCID=

en-aut-name=InagakiMasaru
en-aut-sei=Inagaki
en-aut-mei=Masaru
kn-aut-name=稲垣優
kn-aut-sei=稲垣
kn-aut-mei=優
aut-affil-num=13
ORCID=

en-aut-name=SadamoriHiroshi
en-aut-sei=Sadamori
en-aut-mei=Hiroshi
kn-aut-name=貞森裕
kn-aut-sei=貞森
kn-aut-mei=裕
aut-affil-num=14
ORCID=

en-aut-name=KamikawaYasuaki
en-aut-sei=Kamikawa
en-aut-mei=Yasuaki
kn-aut-name=上川康明
kn-aut-sei=上川
kn-aut-mei=康明
aut-affil-num=15
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=2
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=3
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=4
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=5
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=6
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=7
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=8
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=9
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=10
en-affil=
kn-affil=岡山大学外科学第一講座

affil-num=11
en-affil=
kn-affil=岡山大学内科学第一講座

affil-num=12
en-affil=
kn-affil=岡山大学内科学第一講座

affil-num=13
en-affil=
kn-affil=高知県立中央病院外科

affil-num=14
en-affil=
kn-affil=福山市民病院

affil-num=15
en-affil=
kn-affil=三原赤十字病院
en-keyword=living related
kn-keyword=living related
en-keyword=liver transplantation
kn-keyword=liver transplantation
en-keyword=primary biliary cirrhosis
kn-keyword=primary biliary cirrhosis
en-keyword=adult
kn-keyword=adult
END