JaLCDOI 10.18926/19821
Title Alternative Interstitial matrix components in relation to the pathogenesis of fibrosis
FullText URL 060_076_082.pdf
Author Seno, Toshinobu| Harada, Hideo| Ochi, Koji| Tanaka, Juntaro| Matsumoto, Shuji| Ishibashi, Tadaaki| Takeda, Masahiko| Miyake, Hirofumi|
Abstract 慢性膵炎の症例は近年増加の一途をたどっており,その発症機序と病態の解明および対策の確立が急がれている。慢性膵炎の重要な所見の一つである膵間質線維化の発生機序の解明および早期発見法の確立は重要な課題であるが,従来の知見は断片的にすぎない。そこで,筆者らは膵線維化の系統的な研究を始めるにあたって,細胞間マトリックスの構成成分と線維化に関する従来の知見および今後の課題を整理した。細胞間マトリックスのうちでも特にコラーゲン,グリコサミノグリカン,フィブロネクチンをとりあげ,その構造と機能および組織の線維化形成における役割について文献的考察を行った。今後,膵組織および膵液中のプロリンハイドロキシラーゼ,コラーゲンとその型別分布および各型コラーゲンの比,ヘキソサミン,デルマタン硫酸,フィブロネクチン,ラミニンを検討することが重要と思われた。
Abstract Alternative Increasing numbers of patients with chronic pancreatitis have been reported all over the world, including Japan. Pathogenesis of chronic pancreatitis has remained to be revealed and the early detection has remaind difficult despite extensive investigations. Interstitial fibrosis forms one of the most important histopathological features of chronic pancreatitis along with loss of parenchyma and irregular dilatation of the ducts and ductules. However, only a limited numbers of reports have been pubiished on the pathogenetic mechanisms of interstitial fibrosis of the pancres, because tissue materials are not easily accessible and blood samples can hardly reflect the fibrotic process of the pancreas unlike the case of the iiver. Our Preliminary studies revealed that biochemical and immunochemical analysis of pure pancreatic juice, such as determination of collagen, hexosamine, fibronectin and proline hydroxylase, might reflect the fibrotic process of the pancreas. The results led us to review the earlier reports on inter-cellular matrix in relation to the formation of fibrosis to find suitable markers to be evaluated in the future systematic investigations. The review revealed that pure pancreatic juice should be analyzed for collagen, types of collagen, hexosamine, dermatan sulfate, fibronectin, larninin, proline hydroxylase, collagenase and cathepsin B(1).
Keywords 慢性膵炎 (Chronic pancreatitis) 膵の線維化 (Interstitial fibrosis of the pancreas) 膵間質成分 (Interstitial matrix of the pancreas)
Publication Title 環境病態研報告
Published Date 1989-07
Volume volume60
Start Page 76
End Page 82
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002309179
JaLCDOI 10.18926/19817
Title Alternative Radiation horrnesis with Radon baths
FullText URL 060_072_075.pdf
Author Komoto, Yoshiaki| Tokunoh, Teruo| Soda, Mitsuhiro| Hirai, Shunichi| Morisue, Shinhachi| Suzuka, Ichio| Sunakawa, Mitsuru| Yorozu, Hidenori|
Abstract ラドン泉浴の保温作用は,薬効的には高濃度(13,764-23,743Bq/ℓ)ラドンの吸入による組織循環の改善による。ラドンによる脈管作動的機序はなお明らかにし得ていないが,末梢循環改着作用に基づく保温効果は疲労回復,及び退行性変性の慢性疼痛緩解に適応を有する。生物に対する放射能は,すべて有害とする認識が一般的であるが,自然放射能を含めてその刺激作用によりbio-positiveの恩恵を受けている。ラドン泉浴によるbio-negativeの報告も見られる中で,ホメオスターシスの維持に必要なbio-positiveなhormetic effectsとしての刺激作用の解明が望まれる。
Abstract Alternative Radon bathings is indicated for chronic pain caused by degenerative changes in connective tissues by warming effect as a result of the improvement in tissue perfusion based on the experimental inhalation study for high concentration of Radon (13,764-23,743 Bq/ℓ). Radioactive radiation has been thought to be bio-negative in general. The environmental radiation in Misasa hospital of 80.7±7.8mBq/ℓ and 265.8±98.8mBq/ℓ in the steam bath room (727-2,395% of Rn-free district) may contribute on Rn spa therapy, as we have no experiences of bio-negative effects of Rn on epidemiology study. It seems probable that the early data of cosmic radiation effects to promote reproduction rate on the primitive organisms have significance and that the ambient radiation is essential for normal physiological function and life of the living organisms. In order to share the benefit of hormetic effects (hormesis) with Radon springs, optimal dosis should be determined together with the development of precise micro-dosimetry.
Keywords ラドン泉 (Radon springs) 適応症 (lndications) 放射能泉 (Radioactive springs) ホルミシス (Hormesis)
Publication Title 環境病態研報告
Published Date 1989-07
Volume volume60
Start Page 72
End Page 75
ISSN 09133771
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/6511
language 日本語
File Version publisher
NAID 120005816789
JaLCDOI 10.18926/19813
Title Alternative Absolute ethanol injection for non-parasitic hepatic cyst.
FullText URL 060_067_071.pdf
Author Morisue, Shinhachi| Suzuka, Ichio| Hirai, Shunichi| Soda, Mitshiro| Tokuno, Teruo| Komoto, Yoshiaki| Sunakawa, Mitsuru| Yorozu, Hidenori| Komatsubara, Shokichi| Teramoto, Shigeru|
Abstract 非寄生虫性肝嚢胞の3例に,超音波ガイド下にドレナージ及び純エタノール注入を行い,全例に嚢胞の著明な縮小効果を認めた。本法は手技も容易で,副作用も軽微であり,エタノール注入と嚢胞縮小効果の間には1カ月以上の時間的な経過を要するが,肝嚢胞に対して,外科的療法に代わる有用な治療法であると思われる。
Abstract Alternative Three patients suffering from nonparasitic hepatic cysts were successfully treated with absolute ethanol injection under ultrasonic guided puncture. As the procedure was simple and less invasive, it was considered that this treatment for hepatic cysts was an alternative to surgery. However, more than one month was needed, untill remqrkable shrinkage of cysts was expected in all three patients.
Keywords 肝嚢胞 (Liver cyst) 超音波ガイド下穿刺術 (Ethanol injection) エタノール注入療法 (Transcutaneous hepatic puncture)
Publication Title 環境病態研報告
Published Date 1989-07
Volume volume60
Start Page 67
End Page 71
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309013
JaLCDOI 10.18926/19808
Title Alternative Clinical studies on serum cortisol levels in patients with intractable asthma
FullText URL 060_061_066.pdf
Author Araki, Hiroyuki| Kitani, Hikaru| Sudo, Michiyasu| Tanizaki, Yoshiro| Tada, Sinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract 重症難治性喘息におけるステロイド剤の副腎皮質機能,免疫能に及ぼす影響を調べるため,喘息患者65例を過去3年間のステロイド剤使用状況により,Ⅰ群:依存性症例,Ⅱ群:時に使用する症例,Ⅲ群:非使用例の3群に分け,血清コルチゾール値,末梢血リンパ球数及び血清免疫グロブリンについて検討した。結果は,血清コルチゾール値:Ⅰ群4.0μg/dℓ,Ⅲ群11.6μg/dℓ,末梢血リンパ球数:Ⅰ群1,659/mm(3)Ⅲ群2,150/mm(3),I gG:Ⅰ群1,062mg/dℓ,Ⅲ群1.501mg/dℓ,IgA:Ⅰ群218mg/dℓ,Ⅲ群279mg/dℓ,IgM:Ⅰ群148mg/dℓ,Ⅲ群227mg/dℓとⅠ群はⅢ群に比べ有意に低い平均値を示しステロイド剤の副腎皮質機能,免疫能への抑制作用が窺われた。また末梢血リンパ球数の減少は,高齢者のステロイド依存性例に顕著であった。
Abstract Alternative In order to investigate adverse effects of steroid therapy on adrenocortical function and immune function, serum cortisol levels, peripheral lymphocytes' counts and serum immuno-globulin levels were examined in 65 asthmatic patients. The asthmatic patients were classified into 3 groups according to steroid therapy for the past 3 years ; group Ⅰ has been treated with continuous steroid therapy, group Ⅱ with occasional steroid therapy and group Ⅲ without steroid therapy. The results were as follows. 1. The mean of serum cortisol levels was lower significantly in group Ⅰ as compared with that in group Ⅲ, (groupⅠ:4.0μg/dℓ, groupⅢ:11.6μg/dℓ). 2. The average count of peripheral lymphocytes was more decreased in group Ⅰ than in group Ⅲ. The difference between the two groups was significantly, (group Ⅰ:1659/mm(3), group Ⅲ:2150/mm(3)). 3. The average levels of serum immunoglobinlins such as IgG, IgA and IgM was  significantly lower in group Ⅰ compared with that in group Ⅲ, (group Ⅰ :IgG 1062mg/dℓ, IgA 218mg/dℓ, IgM 148mg/dℓ, group Ⅲ: IgG 1501mg/dℓ, IgA 279mg/de, IgM 227mg/dℓ). The results suggested that long-tetm steroid therapy remarkably suppressed adrenocortical function and immune function in patients with asthma.
Keywords 重症難治性喘息 (Intractable asthma) 血清コルチゾール (Serum cortisol) 末梢血リンパ球 (Peripheral lymphocytes) 血清免疫グロブリン (Serum immunoglobuiin)
Publication Title 環境病態研報告
Published Date 1989-07
Volume volume60
Start Page 61
End Page 66
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309108
JaLCDOI 10.18926/19805
Title Alternative Clinical studies on bronchial asthma induced by chironomid midges -comparison between positive and negative cases to house dust-
FullText URL 060_054_060.pdf
Author Kitani, Hikaru| Araki, Hiroyuki| Sudo, Michiyasu| Tanizaki, Yoshiro| Tada, Sinya| Takahashi, Kiyoshi| Kimura, Ikuro| Matsuoka, Hiroyuki| Ishii, Akira|
Abstract 近年ユスリカが気管支喘息の原因抗原となり得ることが報告されている。しかし,その臨床的特徴はいまだ明らかにされていない。このユスリカ抗原の特徴を検討する目的で,気管支喘息症例163例をHD(ハウスダスト)に感作されたRAST score2+以上の陽性例82例とscore1+以下の陰性例81例とに分けて比較検討を行なった。その結果皮膚反応,ヒスタミン遊離,CTT抗原を用いた特異的IgE抗体いずれの検討においても,HDに感作された症例が,よりユスリカ抗原にも感作されやすいことが明らかになった。
Abstract Alternative In recent years it has been reported that chironomid migdes might be one of the causative allergens in bronchial asthma. In order to clarify the clinical characteristics of bronchial asthma induced by chironomid midges (Tokunagayusurika akamusi), 163 patients with bronchial asthma were studied. The subjects were divided into two groups ; cases with negative (0~1 + ) and positive (2 + or more) RAST score to house dust. 1. Skin reaction to midges was positive in 54 cases (33.1%) out of 163 patients with bronchial asthma. Thirty-six cases (43.9%) out of 82 asthmatics with positive RAST score to house dust showed positive skin reaction to midges, but in 81 cases with negative RAST score, only 18 cases (22.2%) showed positive skin reaction. 2. Fourteen cases out of 85 asthmatics showed a significant amount of histamine release (more than 15%). A significant amount of histamine release was observed in 12 cases (23.5%) out of 51 cases with positive RAST score, but in only two cases (5.9%) out of 24 cases with negative RAST score. 3. Specific IgE antibodies to CTT (Chiromonus thummi thummi) was positive in 12 cases (18.2%) out of 66 asthmatics. In 41 asthmatics with positive RAST score to house dust, 12 cases (29.3%) showed positive RAST score to CTT, though in 25 cases with negative RAST score to house dust no cases showed positive RAST score to CTT. In conclusion, cases with house dust allergy were more easily sensitized by chironomid migdes than those cases without house dust allergy.
Keywords 気管支喘息 (Bronchial asthma) ユスリカ (Chironomid midges) ヒスタミン遊離 (Histamine release) ハウスダスト (House dust)
Publication Title 環境病態研報告
Published Date 1989-07
Volume volume60
Start Page 54
End Page 60
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309057
JaLCDOI 10.18926/19802
Title Alternative IgE-mediated reaction in non-atopic asthma
FullText URL 060_047_053.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Araki, Hiroyuki|
Abstract 気管支喘息の発症にIgE抗体がどの程度関与しているのかを中心に若干の検討を加えた。1.若年発症型喘息(発症;20才以下,現年齢;30才以下)では,非難治例15例の血清IgE値は947±656IU/mℓで,HDのRASTが陽性を示した症例は12例(80%),難治例12例では血清IgE値214±102IU/mℓで,HDのRAST陽性は6例(50.0%)であった。2.一方,中高年発症型喘息(発症;40才以後)では,非難治例15例の血清IgE値は388±324IU/mℓで,HDのRAST陽性は6例(40%)であったが,難治例15例ではIgE値253±82IU/mℓで,HDのRASTは全例陰性であった。これらの結果から,いずれの群においても,IgE系反応が弱い場合に喘息が重症化しやすいことが示された。3.アトピー型,健康人,非アトピー型におけるI1gE系反応(皮内反応,血剤IgE,特異的IgE,ヒスタミン遊離)の陽性率や強度は,それぞれ異なっていたが,非アトピー型においてもIgE系反応が低下ないし抑制された状態で関与している可能性が示唆された。
Abstract Alternative IgE-mediated reaction was studied in non-atopic asthma in comparison with atopic asthma. 1. In early onset asthma patients (younger than 20 years at onset of the disease), the mean serum IgE level was 947±656IU/mℓ in non-intractable asthma cases and 214±102IU/mℓ in intractable cases. A positive RAST score to house dust was observed in 12 cases (80%) out of 15 non-intractable cases, and 6 (50%)out of 15 intractable cases. 2. In late onset asthma patients (older than 40 years at onset), the mean serum IgE level was 388±324IU/mℓ in non-intractable cases and 253±82IU/mℓ in intractable cases. There were no cases with a positive RAST score to house dust in intractable cases. These results may suggest that there is a correlation between decreased IgE-mediated reaction and a tendency to intractable asthma. 3. There were some differences in IgE mediated reaction among atopic, non-atopic asthma cases and healthy subjects, suggesting that IgE-mediated reaction may partially participate in the onset of non-atopic asthma in a suppressed condition.
Keywords アトピー型喘息 (Atopic asthma) 非アトピー型喘息 (Non-atopic asthma) 皮内反応 (Skin reaction)  血清IgE (Serum lgE) 特異的lgE (Specific lgE)
Publication Title 環境病態研報告
Published Date 1989-07
Volume volume60
Start Page 47
End Page 53
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309025
JaLCDOI 10.18926/19797
Title Alternative Clinical evaluation of co-examination by sigmoidoscopy and barium enema study for early diagnosis of colon cancer
FullText URL 060_039_046.pdf
Author Ochi, Koji| Ishibashi, Tadaaki| Matsumoto, Shuji| Seno, Toshinobu| Tanaka, Juntaro| Harada, Hideo| Akiyama, Tsuneo| Nakai, Mutsurou| Hayashimoto, Kanae|
Abstract 注腸・内視鏡同日併用法の大腸早期癌診断における有用性の検討,その診断能向上のための検査前日食改善を目的に,同法を施行した94例の診断能,従来のBrown変法に準じた献立食とレトルト食(サンケンクリン)とのX線画像の質,内視鏡時の残渣の程度,被検者への味のアンケートを分析した。発見大腸腫瘍は癌5例(早期癌2例,進行癌3例),ポリープ26例32病変である。早期癌はともにポリープの形態をとり,注腸,内視鏡とも病変を指摘できた。病変の好発部位である直腸・S状結腸で注腸・内視鏡によるダブルチェックができる。前日食の検討ではレトルト食が従来の献立食と比し,注腸・内視鏡ともに優れた腸内洗浄能を有し,味のアンケートからも劣ることはなかった。大腸癌早期発見の2次スクリーニングとして,レトルト食を前日食とする同法の有用性が示された。
Abstract Alternative The present study was performed (1) to evaluate the validity of co-examination by sigmoidoscopy and barium enema study for the early diagnosis of colon cancer and (2) to find the most suitable preparation method for the co-examination. The co-examination was performed on 94 patients : those with abdominal symptoms and signs suggestive of colonic diseases : those with positive occult blood test in stool : or those asking for the routine examination of the colon. The examination revealed 5 cases of colon cancer (2 with early cancer and 3 with advanced cancer) and 26 eases (32 lesions) with colon polyp. The high detection rate of colonic neoplasms, especially of minute lesions, along with the high rate of early lesions among cancers suggested the validity of the co-examination method for the early diagnosis of colon cancer. The method was not time-consuming and not demanding for both patients and doctors, but was effective in detecting minute lesions by allowing a doublecheck in the high-risk recto-sigmpid region ; in addition, the upper colon could be examined by X-ray. The comparative studies on the currently popular Preparation method (modified Brown's method) and a new method with retort foods (Sankenclean, Sanwa Kagaku Kenkyusho Co., Ltd) revealed that the latter was significantly more effective in cleaning colon lumen and visualizing fine network pattern of the colonic mucosa. In addition, the patients were more satisfied with the taste of the latter.
Keywords 大腸早期癌 (Ealry diagnosis of colon cancer) 注腸・内視鏡同日併用法 (Co-examination by sigmoidoscopy and barium enema study) 大腸検査前処置 (Preparation for colon examination)
Publication Title 環境病態研報告
Published Date 1989-07
Volume volume60
Start Page 39
End Page 46
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002309136
JaLCDOI 10.18926/19793
Title Alternative Maternity swimmlng at Misasa Hospital of Okayama University Medical School. Second report. The indication and its practice.
FullText URL 060_035_038.pdf
Author Okuda, Hiroyuki| Kondou, Yuji| Sakata, Junko| Yosida, Sachie| Tanizaki, Yosiro|
Abstract 第一報において,当科外来通院妊婦を対象とした妊婦水泳に関するアンケート調査の結果を報告1)したが,その結果にもとづき,1988年2月より妊婦水泳を開始し,11カ月を経過した。この間,初産婦および前回難産経験をもつ経産婦を主たる対象として,積極的に水泳を奨めた結果,18例の妊婦水泳を経験することができた。その結果,流早産例は1例もなく,児の予後も良好であり,妊婦管理の一環としての妊婦水泳の安全性と有用性が確認できたので,当科における妊婦水泳の現状とその適応につき報告する。
Abstract Alternative From February to December, 1988, 18 cases of maternity swimming were deliverd at Misasa hospital of Okayama university medical school. Then we discussed the indication, safety and effectiveness of maternity swimmmg. (Results) (1) Fifteen cases (83.3%) were primiparas and 5 cases (27.8%) were 30 years old or more. (2) As for the weeks of pregnancy at the beginning of swimming, the earliest one was at 18 weeks and the latest one was at 37 weeks. (3) The times of swimming during pregnancy were variou in each case, and the maxirnum one was 20 times and the minimum one was 2 times. (4) There was no abortion and premature delivery. (5) There was no low birth weight infant and no asphxia of the newborn. (Conclusion) The inducement of maternity swimming is safe and effective to the management of pregnancy, especially to the cases of primipara, old aged or having minor disturbance.
Keywords 妊婦水泳 (Maternity swimming)
Publication Title 環境病態研報告
Published Date 1989-07
Volume volume60
Start Page 35
End Page 38
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309143
JaLCDOI 10.18926/19790
Title Alternative Oxygen inhalation therapy for chronic venous ulcer. -An additional treatment modality-
FullText URL 060_031_034.pdf
Author Komoto, Yoshiaki| Tokunou, Teruo| Soda, Mitsuhiro| Hirai, Shunichi| Morisue, Shinnhachi| Suzuka, Ichio| Sunakawa, Mitsuru| Yorozu, Hidenori|
Abstract 長期にわたり反復する静脈性潰瘍は,静脈圧亢進により拡張した毛細管の増加とその周辺に滲出したフィブリンの沈着により,血液からの酸素,及び栄養物の供給が妨げられている。医用質量分析装置による皮下組織ガス分圧の評価で経鼻的に100 % の酸素吸入により潰瘍周辺への酸素供給が認められたので,重篤臨床例に対して静脈圧減圧処置に加えて酸素吸入を併用したところ,潰瘍の治癒傾向は著しく速くなり,補助療法としての意義を認めた。
Abstract Alternative Prolonged venous hypertension leads to increase the number of dilated capillaries and to fibrin deposition around them which may form a barrier to the diffusion of oxygen and other nutrients from the blood to the tissue, so that cell death and ulceration may occur. Following inhalation of 100 % -O(2), increased partial pressure of subcutaneous tissue oxygen (pO(2)) around the ulcer was confirmed by means of medical mass spectrometry, which was found comparable to or higher than the level of ulcer-free area (chest) on room air. Four patients suffering from chroriic ulcers were successfully treated by 100 % -O(2) inhalation, 4-5 ℓ/min, for one hour every day in addition to the simpie measures of reducing venous stasis. Suffice it to say that the inhalation of 100 % -O(2) may be applicative to an additional treatment modality in chronic venous ulceration, though inhalation of 100 % -O(2) for a long period of time may not be recommended.
Keywords 慢性静脈性潰瘍 (Chronic venous ulcer) 組織ガス分圧 (Partial pressure of tissue gases) 医用質量分析装置 (Medical mass spectrometer) 酸素拡散 (Oxygen diffusion) 酸素吸入療法 (Oxygen inhalation therapy)
Publication Title 環境病態研報告
Published Date 1989-07
Volume volume60
Start Page 31
End Page 34
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309180
JaLCDOI 10.18926/19785
Title Alternative Spa therapy for bronchial asthma -Clinicai studies on 93 cases with bronchial asthma-
FullText URL 060_025_030.pdf
Author Sudo, Michiyasu| Araki, Hiroyuki| Kitani, Hikaru| Tanizaki, Yoshiro|
Abstract 1982年1月から1988年12月までの7年間に三朝分院内科に入院し,温泉療法を受けた気管支喘息93例を対象に,その背景因子,免疫アレルギー学的要素および温泉療法の臨床効果について総合的に検討した。1.年齢の平均は52.6才,発症年齢の平均は41.7才であり,両者ともやや高齢であった。2.血清IgE値の平均は506.2IU/mℓであった。300IU/mℓ以下の症例は59例(63.4%)であり,半数以上の症例が血清IgE値正常ないし低値を示した。3.皮内反応ではカンジダに陽性を示す症例が44例と最も多く,次にハウスダスト(以下HDと略す)26例,スギ13例,キヌ8例であった。4.換気機能検査では気管支攣縮型において換気機能の低下傾向が最も少なく,細気管支閉塞型で換気機能の低下傾向が特に% MMF,% V(50),% V(25)のような細気管支の閉塞を示すパラメーターの低下傾向がより高度であった。5.対象症例の臨床病型は気管支攣縮型が47例でほぼ対象症例の半数を占め次いで気管支攣縮+過分泌型29例,細気管支閉塞型17例の順であった。6.温泉療法の全般的有効率は79.6%であった。臨床病型別では細気管支閉塞型17例中16例(94.1%)が有効例であり,細気管支閉塞型で最も有効例がみられた。
Abstract Alternative Allergological characteristics and factors of spa therapy in relation to clinical effects were studied on 93 patients, who were adirnitted at Misasa Branch Hospital from 1982 to 1988. Fifty-seven out of 93 cases were steroid-dependent intractable asthma. 1. The mean age was 52.6 and the mean age at onset was 41.7 years old. The age and age at onset were higher ip these asthma cases. 2. The mean serum IgE levels was 506.2IU/mℓ. Serum IgE levels were generally low, and less than 300IU/mℓ in many cases. 3. Frequency of positive skin reactions to various allergens was generally low, and considerably higher in the two allergens, candida albicans and house dust. Cases with posiitive RAST score was most frequently observed in house dust, followed by candida albicans and J. cedar. 4. Ventilatory function tests of these patients showed that % V(50), % V(25)and % MMF which represent small airway obstruction were less decreased in bronchospasm type and most deereased in bronchiolar obstruction type. 5. The bronchospasm type was most frequently observed, followed by bronchospasm-hypersecretion type and bronchiolar obstruction type. 6. Spa therapy was effective in 74 cases (79.6%) out of the 93 patients, and regarding clinical classification of asthma type, spa therapy was most effective in the cases with bronchiolar obstruction type.
Keywords 気管支喘息 (Bronchial asthma) 温泉療法 (Spa therapy) 臨床病型 (Asthma type)
Publication Title 環境病態研報告
Published Date 1989-07
Volume volume60
Start Page 25
End Page 30
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309015
JaLCDOI 10.18926/19779
Title Alternative Spa therapy for bronchial asthma-Clinical effects of inhalation of iodine salt soluions.
FullText URL 060_019_024.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Araki, Hiroyuki|
Abstract 気管支喘息20例を対象に,ヨードゾル吸入療法を行ない,その臨床効果について検討を加えた。1.ヨードゾル2週間吸入後の臨床効果判定では,著効4例(20%),有効11例(75%),やや有効4例(20%),無効1例(5%)であり,有効以上の明らかな有効例は20例中15例(75%)であった。また臨床病型別の効果の検討では,明らかな有効例は,Ⅰa.気管支攣縮型では9例中6例(66.7%),Ⅰb.気管支攣縮+過分泌型では9例中7例(77.8%)であった。一方,Ⅱ.細気管支閉塞型では2例いずれも有効であった。2.ヨードゾル1回吸入後の換気機能の改善率は,FVC8.5%,FEV(1.0)11.0%,PEFR9.7%,MMF12.2%, V(50)14.4%, V(25)14.8%であり,閉塞性換気障害を示すパラメーターの改善率がやや高く,なかでも小さい気道の換気障害と関連の深いMMFやV(25)の改善率が高い傾向がみられた。
Abstract Alternative Clinical effects of inhalation therapy by iodine salt solutions were studied in 20 patients with bronchial asthma. 1. Inhalation therapy by iodine salt solutions was markedly effective in 4 cases (20%), moderately in 11 cases (55%), slightly in 4 cases (20%) and not effective in 1 case (5 % ). Number of the effective cases was 6 (66.7%) out of 9 cases with bronchospasm type (Ⅰa), and 7 (77.8%) out of 9 cases with bronchospasm+ hypersecretion type (Ⅰb), respectively. The inhalation therapy was also effective in all two cases with bronchiolar obstruction type (Ⅱ). 2. % Improvement of ventilatory function after inhalation of iodine salt solution was 8.5% in FVC, 11.0% in FEV(1.0), 9.7% in PEFR, 12.2% in MMF, 14.4% in V(50) and 14.8% in V(25). The % increase in ventilatory function was higher in the parameters such as MMF and V(25), representihg ventilatory disturbance of small airways.
Keywords 気管支喘息 (Bronchial asthma) ヨードゾル吸入 (Inhalation of iodine salt sotutlon) 温泉療法 (Spa therapy) 換気機能 (Ventilatory function)
Publication Title 環境病態研報告
Published Date 1989-07
Volume volume60
Start Page 19
End Page 24
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309118
JaLCDOI 10.18926/19777
Title Alternative Spa therapy for bronchial asthma. Effect of spa therapy on adrenal glands function.
FullText URL 060_014_018.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Araki, Hiroyuki|
Abstract 気管支喘息30症例を対象に,血中コーチゾール値を観察することにより,温泉療法の副腎皮質機能に及ぼす影響について検討を加えた。1.対象30症例の平均血中コーチゾール値は,5.64±4.95γ/dℓであった。このうち,ステロイド依存性喘息15例では,2.25±2.51γ/dℓ,ステロイド非使用の喘息15例では,9.02±4.47γ/dℓであり,ステロイド依存性喘息症例で有 意の低下傾向が見られた(P<0.001)。2.1-3カ月間の温泉療法前後での比較では,療法前の平均血中コーチゾール値は5.26±4.98γ/dℓ,後では9.51±5.26γ/dℓであり,温泉療法により有意の上昇がみられた(P<0.05)。3.1回の温泉浴前後の血中コーチゾール値の変動では,変動のみられない群と上昇傾向を示す群の2つの症例群が観察された。このうち,変動のみられない症例群は,もともと血中コーチゾール値が正常であるか,あるいは副腎皮質機能が疲弊してしまっているかのいずれかであった。
Abstract Alternative Effect of spa therapy on adrenai glands function was studied in 30 patients with bronchial asthma, by observing serum cortisol levels. 1. The mean of serum cortisol levels was 5.64±4.95γ/dℓ in all cases, 2.25±2.51γ/dℓ in 15 cases with steroid dependent asthma and 9.02±4.47γ/dℓ in 15 cases without steroid therapy. There was a significant difference between the two groups (P<0.001). 2. Serum cortisol levels were measured before and after spa therapy for 1 to 3 months. The mean of serum cortisol levels increased from 5.26±4.98γ/dℓ before spa therapy, to 9.51±5.26γ/dℓ after spa therapy, which was significantly higher than the former (P<0.05). 3. Changes of serum cortisol levels after hot spring bath fot 20 min were observed. Serum cortisol levels seased in one group, and did not change in the other groups after 20-min hot spring bath. In no change groups of serum cortisol levels, adrenocortical function was normal in one group, and highly damaged in the other group.
Keywords 気管支喘息 (Bronchial asthma) 血中コーチゾール (Serum cortisol level) 温泉浴 (Hot spring bath) 温泉療法 (Spa therapy)
Publication Title 環境病態研報告
Published Date 1989-07
Volume volume60
Start Page 14
End Page 18
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309101
JaLCDOI 10.18926/19776
Title Alternative Spa therapy for chronic respiratory disease- in subjects admitted in 1988.
FullText URL 060_006_013.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Araki, Hiroyuki|
Abstract 1988年1月より12月までの1年間に当院へ入院した慢性呼吸器疾患患者62例を対象に,背景因子,臨床的特徴および温泉療法の臨床効果について検討を加えた。1.対象62例のうちわけは,気管支喘息49例,瀰漫性汎細気管支炎4例,肺気腫4例,アレルギー性肉芽腫性血管炎3例,肺結核,気管支拡張症各1例であった。2.これら62症例のうち,温泉療法を受けた症例は41例(66.1%)であった。3.温泉療法を受けた症例の地域分布では,鳥取県からの入院症例32例では14例(43.8%)であり,同様に岡山県からの入院症例17例では15例(88.2%),その他の県からの入院症例13例では12例(92.3%)であった。4.温泉療法の臨床効果は,気管支喘息では33例中著効12例,有効15例,やや有効5例,無効1例で,明らかな有効例は27例(81.9%)であった。また温泉療法は瀰漫性汎細気管支炎,アレルギー性肉芽腫性血管炎などに対しても有効であった。
Abstract Alternative Backgrounds, immpnological characteristics and clinical effects of spa therapy were examined in patients with chronic respiratory disease admitted at Misasa Branch Hospital in 1988. 1. Sixty two patients with chronic respiratory disease comprised 49 patients with brohchial asthma, 4 with diffuse panbronchiolitis, 4 with pulmonary emphysema, 3 with allergic granulomatous angitis, each 1 with lung tuberculosis and with bronchiectasia. 2. Forty one patients (66.1%) out of the 62 cases had spa therapy. 3. Out of 32 patients coming from Tottori prefecture, 14 cases (43.8%) received spa therapy. On the other hand, spa therapy was carried out for 15 cases (88.2%) out of the 17 cases from Okayama prefecture, and for 12 cases (92.3%) out of the 13 cases from the other prefectures (long distant areas). 4. Spa therapy was effective in 27 cases (81.9%) out of the 33 patients with bronchial asthma. Spa therapy also effective for patients with diffuse panbronchiolitis, and allergic granulomatous angitis.
Keywords 気管支喘息 (Bronchial asthma) 瀰漫性汎細気管支炎 (Diffuse panbronchiolitis) アレルギー性肉芽腫性血管炎 (Allergic granulomatous angitis) 温泉療法 (Spa therapy)
Publication Title 環境病態研報告
Published Date 1989-07
Volume volume60
Start Page 6
End Page 13
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309166
JaLCDOI 10.18926/19775
Title Alternative Effect of long-term daily intake of thermal water on gastric mucosal blood flow
FullText URL 060_001_005.pdf
Author Tanaka, Juntaro| Senou, Toshinobu| Matumoto, Shuji| Ishibashi, Tadaaki| Ochi, Koji| Harada, Hideo|
Abstract 内視鏡(オリンパス製XQ-10胃ファイバースコープ)と臓器反射スペクトル法を応用して,2週間連日の飲泉が胃粘膜血流におよぼす効果を検討した。健常者3名および胃疾患患者9名(治癒期にある胃潰瘍の患者6名と慢性胃炎の患者3名)を対象とした。当院飲泉場の温泉水による2週間連日の飲泉を行ない,2週間の飲泉の前後において,胃の3箇所(胃幽門部小弯,前庭部小弯,胃角部小弯)で胃粘膜血流を測定した。その結果,胃前庭部小弯では胃粘膜血流の有意の増加を認めた。しかし胃全体としては有意差を検出出来なかった。個々の症例について検討すると、飲泉後で胃の3箇所すべてにおいて血流が増加したケースが頻度多く認められ,飲泉の有効性が示唆された。従来から認められてきた慢性胃腸疾患に対する飲泉の効果には,胃粘膜血流の改善による要因も加わっている可能性が考えられる。
Abstract Alternative Effect of long-term oral intake of thermal water on gastric mucosal blood flow was evaluated, using an endoscopic organ reflex spectrophotometry together along with an Olympus XQ-10 forward viewing gastro-fiberscope. Three healthy volunteers and nine patients with gastric diseases in remission (six with healed gastric ulcer and three with chronic gastritis) were put on a 2-week treatment with daily oral intake of Misasa thermal water (38 to 42 ℃, 200mℓ, two times a day between meals). Gastric mucosal blood flow was measured just before and after the treatment period at three spots of the stomach (lesser curvature of the pylorus, antrum and angle) : Life style and drugs were unchanged during the period. Following results were obtained : (1) Pre-and post-treatment gastric mucosal blood flow (IHb) was 95.0±18.0, and 98.2±15.3 at the pylorus, respectively ; 104.8±16.9 and 110.8±12.8 at the antrum, respectively ; 116.1±20.4 and 118.7±18.5 at the angle, respectively. (2) However, Evaluation of each individual case showed that the post-treatment values were higher than the pretreatment ones in 75 % of patients at the pylorus and in 67 % of patients at the antrum and angle, respectively. (3) Student's paired t-test showed that the post-treatment increase in blood flow was statistically significant (p<0.05) only at the antrum. These results suggest that an improvement in gastric mucosal blood flow, along with an improvement in gastric secretion and motility, is also contributory to the favorable therapeutic results of spa-drink in chronic gastric diseases. Further studies are in progress to reveal (1) the clinical significance of the improvement in gastric mucosial blood flow, such asacceleration of healing and maintenance of remission, and (2) the characteristics of patients who are likely to show favorable response to the treatment.
Keywords 飲泉療法 (Spa-drink therapy) 胃粘膜血流 (Gastric mucosal blood flow) 臓器反射スペクトル法 (Organ reflex spectrophotometry)
Publication Title 環境病態研報告
Published Date 1989-07
Volume volume60
Start Page 1
End Page 5
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002309006
JaLCDOI 10.18926/19773
Title Alternative Application of personal computer in X-ray room business.
FullText URL 059_097_101.pdf
Author Nakai, Mutsuo| Akiyama, Tsuneo|
Publication Title 環境病態研報告
Published Date 1988-08
Volume volume59
Start Page 97
End Page 101
ISSN 09133771
language 日本語
File Version publisher
NAID 120002308983
JaLCDOI 10.18926/19772
Title Alternative Changes in X-ray examinations.
FullText URL 059_093_096.pdf
Author Akiyama, Tsuneo| Nakai, Mutsuo|
Publication Title 環境病態研報告
Published Date 1988-08
Volume volume59
Start Page 93
End Page 96
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309032
JaLCDOI 10.18926/19771
Title Alternative トランスフェリンを介する鉄の細胞内取り込み機序 ―特に肝細胞への取り込みにおける内皮細胞の関与について―
FullText URL 059_083_092.pdf
Author Irie, Seiji| Matsumoto, Shuji| Ochi, Koji| Takeda, Masahiko| Tanaka, Juntaro| Harada, Hideo| Mehdi, Tavassoli|
Abstract Transferrin (Tf) is thought to play a pivotal role in iron metabolism of various kinds of cells. Tf has specific receptors on the surface of the cells that require iron. Tf-receptor binding is followed by internalization through a system of coated pits and vesicles. The rapid decline of pH of these vesicles leads to the release and sequestration of iron by the cell. Apotransferrin-receptor complex returns to the cell surface, where under neutral pH conditions, apotransferrin is dissociated from the receptor. Recent advances in cellular and molecular biology, gene cloning and monoclonal antibody technique have elucidated many features of these processes at a molecular level. These advances are briefly reviewed, and particularly, our own observations concerning endothelial mediation of uptake of Tf by hepatocytes are discussed.
Abstract Alternative トランスフェリン(Tf)は鉄代謝において重要な役割を担っている。鉄を必要とする細胞の表面には,Tfの特異的受容体が存在し,Ffは受容体との結合に引き続いて,coated pitsとcoated vesiclesを介して細胞内に取り込まれる(internalization)。Vesicle内での急速なpHの低下にともない,鉄はTfから分離し,細胞内で分画される。一方,鉄を失ったTf(アポTf)は受容体と結合したまま細胞表面にもどり,中性のpHのもとで受容体から解離する。最近の細胞・分子生物学の進歩,遺伝子クローニング,ならびにモノクローナル抗体の開発により,分子レベルで鉄代謝経路が解明されつつある。今回,これまでの主要な知見をまとめ,特に,最近筆者らの研究により明らかとなった,肝の鉄代謝における内皮細胞の役割について考察した。
Keywords Iron uptake (鉄の細胞内取り込み) Transferrin (トランスフェリン) Receptor-Mediated Endocytosis Desialation (脱シアル化) Endothelium (内皮細胞)
Publication Title 環境病態研報告
Published Date 1988-08
Volume volume59
Start Page 83
End Page 92
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002309113
JaLCDOI 10.18926/19770
Title Alternative Etiology and pathogenesis of chronic pancreatitis
FullText URL 059_068_082.pdf
Author Harada, Hideo| Matsumoto, Shuji| Ochi, Koji| Takeda, Masahiko| Senou, Toshinobu| Irie, Seiji| Tanaka, Juntaro|
Abstract 慢性膵炎の成因の主たるものは,アルコール性,特発性,胆石性である。病態面では,社会的・家庭的にもっとも責任が重い壮年期に頑固な疼痛,消化吸収障害,二次性糖尿病のために生活の質が低下することが問題になる。経過中に併発してくる膵およびそのほかの臓器の癌,および糖尿病の合併症による死亡も少なくない。アルコール性慢性膵炎の初期病変の発生機序としては,①膵過分泌の結果として細膵管内に形成される蛋白栓による膵液流出障害と,②蛋白栓あるいはアルコールの直接障害作用による細膵管上皮の損傷,およびその結果生じる膵管狭窄による膵液流出障害が注目されている。膵液流出障害はその上流域に実質細胞の破壊と間質の線維化をおこす。膵液には多くの生化学的異常が認められ,いったん発生した膵管の構造異常とあいまって慢性膵炎進展の原因となる。素因および栄養のアンバランスは発症,進展の促進因子となる。発症を予防し,進展を阻止する手段を開発するためには素因および飲酒・食事を含む環境因子の解析が今後の重要な課題である。
Abstract Alternative Main etiologies of chronic pancreatitis (CP)include "alcoholic" (60%), "idiopathic" (27%)and "biliary" (8%). Clinico-pathological features comprise intractable abdominal pain, maldigestion secodary to exocrine pancreatic insufficiency and diabetes secondary to endocrine pancreatic insufficiency. Death is not infrequent during follow-up. Pathogenesis and evolution of alcoholic CP were discussed in connection with "Big Duct Theory", "Toxic-Metabolic Theory", and "Protein Plug Theory". Diet and congenital predisposition as well as alcoholic comsumption play important roles in various combinations in the pathogenesis and evolution of CP. Important initial lesins of alcoholic CP are probably : (1) pancreatic ductular Obstruction due to proetin plug formation resulting from increased protein and mucoprotein concentration in pancreatic juice ; (2) damage and sloughing of ductular epithelia caused by protein plugs or by a direct toxic effect of ethanol secreted into pancreatic juice, and subsequent ductular stenosis and peri-ductular fibrosis. Parenchymal destruction with interstitial fibrosis is induced upstream to the ductular lesions. These, structural abnormalities and multiple biochemical abnormalities of pancreatic juice further lead to self-perpetuating evolution. Anti-acinar-cell antibody, anti-duet-cell antibody and immune complex in serum are most probably mere epiphenomena and not the causes of CP.
Keywords 慢性膵炎 (Chronic pancreatitis) 成因 (Etiology) 発生機序 (Pathogenesis)
Publication Title 環境病態研報告
Published Date 1988-08
Volume volume59
Start Page 68
End Page 82
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002308982
JaLCDOI 10.18926/19769
Title Alternative Allergic reactions for severe intractable asthma and spa therapy
FullText URL 059_062_067.pdf
Author Tanizaki, Yoshiro|
Abstract 予後良好と言われる気管支喘息が,どのような反応系により重症難治化傾向を取るのか,そして温泉療法がどのように作用するのかについて,若干の検討を加えた。まず関与する反応系は,その惹起相,反応相(液性因子相,細胞性因子相)の組合せにより,代表的な3つの反応系に分類することができる。1)IgE-肥満細胞(惹起相);ヒスタミン(ロイコトリエン)(液性因子相);リンパ球,好塩基球,好酸球(細胞性因子相),2)IgG-好中球;ロイコトリエン;好中球,リンパ球,マクロファージ,3)非IgE系反応;PAF;好酸球,3')非IgE系反応;ロイコトリエン;リンパ球。このような機序がもし存在するとすれば,1)の反応系の関与する喘息はアトピー型喘息,2)は中高年発症型喘息,3)は所謂内因性喘息,3')は中高年発症型喘息として把握される可能性が強い。温泉療法は,気道清浄化作用および副腎皮質機能改善作用により,これらの反応系の発現を抑制する。
Abstract Alternative Reactions for severe intractable asthma and actions of spa therapy on the reactions were discussed. Reactions participatng in onset mechanism of bronchial asthma were divided into three major groups. The first group comprises IgE-mast cell (eliciting phase), histamine (leukotrienes) (reactive phase; humoral phase), and lymphocytes-basophils-eosinophils (reactive phase; cellular phase). The second group comprises IgG-neutrophils, leukotrienes, and neutrophils-lymphocytes-macrophages. The third group is induced by non-IgE reactions, followed by PAF and eosinophils (with blood eosinophilia), and by leukotrienes and lymphocytes (without blood eosinophilia). If these reactions are really present and participate in onset mechanism of bronchial asthma, the first group could be observed in atopic asthma, the second one in late onset asthma, and the third one in so-called intrinsic asthma with blood eosinophilia and in late onset asthma without blood eosinophilia. Spa therapy has clearing actions of airway and improves function of adrenal glands in severe intractable asthma.
Keywords 気管支喘息 (Bronchial asthma) 難治性喘息 (lntractable asthma)  アレルギー反応 (Allergic reaction) 温泉療法 (Spa therapy)
Publication Title 環境病態研報告
Published Date 1988-08
Volume volume59
Start Page 62
End Page 67
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309085
JaLCDOI 10.18926/19767
Title Alternative Changing conception of indication for peripheral arterial reconstruction surgery.
FullText URL 059_054_061.pdf
Author Komoto, Yoshiaki| Nakao, Toshihiko| Sunakawa, Mitsuru| Yagi, Nobuko| Yorozu, Hidenori|
Abstract 末梢動脈の慢性閉塞性疾患に対する直達血行再建術の長期の予後は必ずしも満足できるものではない。合成代用血管は,長期の植え込みにより内被の肥厚,退行性変性,および材質の変性の様な合併症により,特に小口径の合成代用血管の適応は極めて限られたものになっている。一方,医用質量分析装置を用いた虚血肢の実験的研究によると,自由に運動させた犬の虚血肢では,急性期に比較すると3カ月以後その組織循環は有意に増加することが明らかとなった。また,家兎を用いた実験的研究によると,炭酸泉浴に高濃度のラドン吸入を合併すると皮下組織の組織循環が約30%増加して,同時に皮下の酸素分圧が上昇することを確かめた。従って,切迫壊死の症例をのぞいて,末梢動脈の慢性閉塞性疾患々肢,特に間欠性跛行に対しては,自 然予後を考慮して歩行負荷,および炭酸泉,ラドン泉の温泉療法を用いた保存的療法が長期の予後上効果的である。
Abstract Alternative Peripheral arterial reconstruction surgery for chronic occlusive diseases has not always produced satisfactory results according to long-term (5-10 years) follow-up studies. Furthermore, application of synthetic vascular prostheses of small caliber for peripheral reconstruction is quite restricted to certain circumstances, because of the complications derived from long-term implantation such as thickening and degeneration of the inner capsule and deterioration of the grafts used. On the other hand, experimental studies on ischemic limbs revealed a significant increase of tissue perfusion in 3, 6 and 12 months following ischemia was induced (p<0.001) compared with the acute ischemic stage in freely moving dogs by means of medical mass spectrometry. In addition, subcutaneous tissue perfusion was found increased by about 30 % with CO(2) bathings in combination with Radon inhalation of high concentration (over 5000 Bq/l), which was accompanied by an elevation of subcutaneous pO(2). Therefore, medical treatments such as walking exercise and bathings with CO(2) and Radon based on the natural history of chronic peripheral arterial occlusive diseases, particularly intermittent claudication, appear feasible.
Keywords 虚血肢 (lshemic limb) 末梢血行再建術 (Peripheral arterial reconstruction) 組織循環 (Tissue perfusion) 歩行運動 (Walking exercise) 温泉療法 (Balneotherapy)
Publication Title 環境病態研報告
Published Date 1988-08
Volume volume59
Start Page 54
End Page 61
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309045