JaLCDOI 10.18926/15096
Title Alternative 気管支喘息に対する複合温泉療法の作用機序 3.気道炎症反応との関連
FullText URL 067_099_106.pdf
Author Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo|
Abstract The degree and characteristic of airway inflammation were evaluated by the proportions of bronchoalveolar lavage (BAL) cells. Clinical asthma types such as Ia. simple bronchoconstriction, Ib. bronchoconstriction + hypersecretion, and Ⅱ. bronchiolar obstruction correlate with airway inflammation. The increased proportion BAL neutrophils is characteristic of type Ⅱ asthma, and increase in BAL eosinophil count is often observed in type Ib asthma. Bronchial hyperresponsiveness also correlates with airway inflammation. Action of spa therapy has been speculated to be related to airway inflammation, since the therapy has no action inhibiting IgE-mediated allergic reaction. In fact, spa therapy is more effective in patients with type Ib and type Ⅱ than in those with type Ia showing slight degree of airway inflammation. Bronchial hyperresponsiveness is also improved by spa therapy. From a point of view, the direct action of spa therapy may be to clean airways and improve damaged mucous membrane of the airways, leading to suppression of airway inflammation.
Abstract Alternative 気道炎症反応の程度や特徴が,気管支肺胞洗浄液(BAL)中の細胞成分によって評価された。Ia.単純性気管支攣縮型,Ib.気管支攣縮+過分泌型,Ⅱ.細気管支閉塞型などの各臨床病型は気道炎症反応と関連している。BAL液中好中球増多は,Ⅱ型喘息の特徴的所見であり,また好酸球増多はIb型喘息でしばしば観察される。気道過敏性もまた気道炎症反応と関連している。温泉療法の作用機序としては,温泉療法にIgEにmediateされるアレルギー反応(液性因子相)を抑制する作用がないことから,気道炎症反応(細胞性因子相)の抑制が推測されている。実際,温泉療法は,気道炎症反応が軽度なIa型喘息に比べ,Ib型やⅡ型などの明らかに気道炎症反応をともなう病型に対してより有効である。気道過敏性もまた温泉療法により改善される。これらの 結果から,温泉療法は,気道を清浄化し,気道粘膜を正常化することによって,気道炎症反応を抑制していくものと考えられる。
Keywords Spa therapy (温泉療法) Airway inflammation (気道炎症反応) BAL eosinophilia (BAL好酸球増多) BAL neutrophilia (BAL好中球増多) Bronchial asthma (気管支喘息)
Publication Title 岡大三朝分院研究報告
Published Date 1996-11
Volume volume67
Start Page 99
End Page 106
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307894
JaLCDOI 10.18926/15350
FullText URL Mem_Fac_Eng_OU_35_29.pdf
Author Shimamura, Kaoru| Munesawa Yuhji| Uchida, Tetsuya|
Abstract Poly (ethylene-block-vinyl alcohol), which consisted of both hydrophobic and hydrophilic blocks, was prepared by using polyethylene single crystals as starting material. Polyethylene single crystals reacted with fuming nitric acid resulting in long methylene chains with functional groups such as COOH and NO(2) at the ends (the chain length were almost same as the lamellar thickness of polyethylene single crystal). The functionalized methylene chains were allowed to react with 4-aminostyrene to give corresponding amides, i.e., methylene chains with vinyl groups at the ends (macromer). The macromers were extended by block-copolymerization with vinyl acetate, then saponified resulting in PE/PVA block co-polymer. The block copolymer was molded into sheets which were subsequently heat-treated in contact with hydrophilic or hydrophobic media. Depending on the media, the sheet surface changed at high temperature reversibly from hydrophilic to hydrophobic and vice versa. The surface property was fixed by quenching because both blocks were able to crystallize. Thus the surface of this material can be tailored for various purposes at high temperature, and then used in stable at room temperature.
Publication Title Memoirs of the Faculty of Engineering, Okayama University
Published Date 2001-03-27
Volume volume35
Issue issue1-2
Start Page 29
End Page 34
ISSN 0475-0071
language 英語
File Version publisher
NAID 120002307155
JaLCDOI 10.18926/15352
FullText URL Mem_Fac_Eng_OU_35_35.pdf
Author Shimamura, Kaoru| Uchida, Tetsuya| Inoue, Tomohiro|
Abstract Rigid polymer, poly(p-phenylene benzobisthiazole), formed lamellar crystals where the molecular chains were oriented perpendicular to the lamellae. It was supposed that, because of wide distribution in the chain length, the lamellar surface bristled with the chain cilia among which many voids were included. Crystallographically, this region afforded us a transitional structure from full to deficient packings of chains. The structure was analyzed using the scanning probe microscope. In the course the method for imaging one molecular chain end was developed. From the images it was concluded that an isolated long cilius did not move so violently at room temperature.
Publication Title Memoirs of the Faculty of Engineering, Okayama University
Published Date 2001-03-27
Volume volume35
Issue issue1-2
Start Page 35
End Page 40
ISSN 0475-0071
language 英語
File Version publisher
NAID 120002307784
JaLCDOI 10.18926/19622
FullText URL Mem_Fac_Eng_OU_31_1_5.pdf
Author Shimamura, Kaoru| Zhang Chunxiao| Uchida, Tetsuya|
Abstract Rigid polymer poly(p-phenylene benzobisthiazole) was crystallized from dilute solution. Electron microscopy showed that upon quenching, flat fibrils with several nm thick were produced. Subsequent heat treatment in solvent changed the fibril into "shish-kebab". On the other hand, by isothermal crystallization, an aggregate of parallel rod-like crystals was obtained. The molecular chains were accommodated normal to the rod. Based on the observation of crystal morphology, the isothermal crystallization mechanism was proposed. Because of regidity of polymer chains and wide distribution of the molecular length, the chain ends were inevitably included within the crystals resulting in crystal defects such as axial shift, lattice curvature and edge dislocation which were directly observed by lattice imaging.
Publication Title Memoirs of the Faculty of Engineering, Okayama University
Published Date 1996-12-27
Volume volume31
Issue issue1
Start Page 5
End Page 10
ISSN 0475-0071
language 英語
File Version publisher
NAID 120002309167
JaLCDOI 10.18926/19624
FullText URL Mem_Fac_Eng_OU_31_1_11.pdf
Author Zhang Chunxiao| Tanigawa Satoshi| Uchida, Tetsuya| Shimamura, Kaoru|
Abstract Poly[(benzo[1,2-d:5,4-d']bissthiazole-2,6-diyl)-1,4-phenylene](cis-PBZT)with a relatively high molecular weight was prepared by a new synthesis route. Properties of the synthesized polymer, such as thermostability, liquid crystallinity etc. were investigated and compared with those of trans-PBZT. cis-PBZT was crystallized from dilute solution and the electron microscopy showed that the precipitate was a rod-like crystal similar to that of trans form. In spite of rigid nature of the back bone, cis-PBZT showed poor crystallinity.
Publication Title Memoirs of the Faculty of Engineering, Okayama University
Published Date 1996-12-27
Volume volume31
Issue issue1
Start Page 11
End Page 17
ISSN 0475-0071
language 英語
File Version publisher
NAID 120002309203
JaLCDOI 10.18926/14088
FullText URL Mem_Fac_Eng_OU_41_1_93.pdf
Author Tarequl Islam Bhuiyan| Nakanishi, Makoto| Fujii, Tatsuo| Takada, Jun|
Abstract Co-precipitation method has been employed to fabricate neodymium substituted hematite with different compositions from the aqueous solution of their corresponding metal salts. Thermal analysis and X-ray diffraction studies revealed the coexistence of Fe(2)O(3) and Nd(2)O(3) phases up to 1050℃ and formation of solid solution phase among them at 1100℃ and above temperatures, which was evidenced by shifting of the XRD peaks. Unit cell parameters and the cell volumes of the samples were found to increase by adding Nd(3+) ions in the reaction process. FESEM studies showed the suppression of particle growth due to the presence of Nd(3+) ions. Spectroscopic measurement evidenced that neodymium substituted hematite exhibited brighter yellowish red color tone than that of pure α-Fe(2)O(3).
Publication Title Memoirs of the Faculty of Engineering, Okayama University
Published Date 2007-01
Volume volume41
Issue issue1
Start Page 93
End Page 98
ISSN 0475-0071
language 英語
File Version publisher
NAID 120002308163
Author 岩﨑 志保| 池田 晋| 野崎 貴博| 山本 悦世|
Published Date 2010-02-26
Publication Title 岡山大学埋蔵文化財調査研究センター紀要
Volume volume2008
Content Type Departmental Bulletin Paper
Author 野崎 貴博| 岩崎 志保| 鈴木 茂之| 山本 悦世| 南 健太郎| 田中 克典| 加藤 鎌司|
Published Date 2013-12-27
Publication Title 岡山大学埋蔵文化財調査研究センター紀要
Volume volume2012
Content Type Departmental Bulletin Paper
Title Alternative Bulletin of Archaelogical Research Center Okayama University 2013
FullText URL barc_2013.pdf
Author 野崎 貴博| 南 健太郎| 岩崎 志保| 吉田生物研究所| 甲元 眞之|
Publication Title 岡山大学埋蔵文化財調査研究センター紀要
Published Date 2015-03-06
Volume volume2013
language 日本語
Copyright Holders Archaeological Research Center, Okayama University
File Version publisher
Pages v, 82 p.
Title Alternative Bulletin of Archaeological Research Center Okayama University 2016
FullText URL barc_2016.pdf
Author Yamaguchi, Yuji| Yamamoto, Etsuyo| Suzuki, Shigeyuki| Iwasaki, Shiho| 白石 純| Minami, Kentaro| Nozaki, Takahiro| 佐藤 朗| 二宮 和彦|
Publication Title 岡山大学埋蔵文化財調査研究センター紀要
Published Date 2018-03-28
Volume volume2016
language 日本語
File Version publisher
Pages 86
Title Alternative Bulletin of Archaeological Research Center Okayama University 2017
FullText URL 紀要2017.pdf
Author Nozaki, Takahiro| Minami, Kentaro| Yamamoto, Etsuyo| Suzuki, Shigeyuki| Yamaguchi, Yuji| Iwasaki, Shiho| 古環境センター| 吉田生物研究所|
Publication Title 岡山大学埋蔵文化財調査研究センター紀要
Published Date 2019-03-29
Volume volume2017
language 日本語
Copyright Holders Archaeological Research Center, Okayama University
File Version publisher
Pages v, 96 p.
Title Alternative Bulletin of Archaeological Research Center Okayama University 2018
FullText URL 紀要2018.pdf
Author Minami, Kentaro| Iwasaki, Shiho| 那須 浩郞| Yamamoto, Etsuyo| Yamaguchi, Yuji| 富岡 直人| 米田 穣| 大久保 徹也| 藁科 哲男| Nozaki, Takahiro|
Publication Title 岡山大学埋蔵文化財調査研究センター紀要
Published Date 2020-03-27
Volume volume2018
language 日本語
Copyright Holders Archaeological Research Center, Okayama University
File Version publisher
Pages v, 99 p.
Author Wakimoto, Kyoko|
Published Date 2006
Publication Title 岡山大学教育学部研究集録
Volume volume131
Issue issue1
Content Type Departmental Bulletin Paper
Author Wakimoto, Kyoko|
Published Date 2006
Publication Title 岡山大学教育学部研究集録
Volume volume133
Issue issue1
Content Type Departmental Bulletin Paper
Author Wakimoto, Kyoko|
Published Date 2007-03
Publication Title 岡山大学教育学部研究集録
Volume volume134
Issue issue1
Content Type Departmental Bulletin Paper
Author Funahashi, Hiroaki|
Published Date 1998-02
Publication Title 岡山大学農学部学術報告
Volume volume87
Issue issue1
Content Type Departmental Bulletin Paper
Author Wakimoto, Kyoko|
Published Date 2007-06-25
Publication Title 岡山大学教育学部研究集録
Volume volume135
Issue issue1
Content Type Departmental Bulletin Paper
Author Yoshitoshi, Munehisa| Nishimura, Noriko| Miyoshi, Mituko| Yokouchi, Rie| Masuda, Yasuko| Uraike, Satoko| Nishi, Sachiyo|
Published Date 2007-06-25
Publication Title 岡山大学教育学部研究集録
Volume volume135
Issue issue1
Content Type Departmental Bulletin Paper
Author Wakimoto, Kyoko|
Published Date 2007-10-25
Publication Title 岡山大学教育学部研究集録
Volume volume136
Issue issue1
Content Type Departmental Bulletin Paper
Author Wakimoto, Kyoko|
Published Date 2008-02-25
Publication Title 岡山大学教育学部研究集録
Volume volume137
Issue issue1
Content Type Departmental Bulletin Paper