JaLCDOI 10.18926/11789
Title Alternative Enzyme Immunoassay for Rabbit C-reactive Protein
FullText URL 002_023_028.pdf
Author Mori, Shuji|
Abstract Sensitive enzyme Immunoassay method specific for rabbit C-reactive protein was established. This was based upon specific Ca(2+)-dependent binding profile of C-reactive protein for some compounds containing phosphorylcholine moiety intramolecularly. By this method, more than 0.001μg of rabbit C-reactive protein was detectable. Specific binding of C-reactive protein for p-aminophenylphosphorylcholine immobilized on solid phase was inhibited by either addition of EDTA or phophorylcholine analogues, effectively. It may be useful to study possible roles of C-reactive protein in inflammatory regions.
Abstract Alternative ウサギC-反応性蛋白質を感度良く測定できる酵素免疫測定法を開発した。本法は、C-反応性蛋白質が分子内にホスホリルコリンを含有する種々の化合物に対してCa(2+)依存的な結合活性を示すことに基づいており、本法によって0.001μg以上のC-反応性蛋白質の検出が可能となった。固相に結合させたp-アミノフェニルホスホリルコリンへのC-反応性蛋白質の特異的な結合活性はEDTAやホスホリルコリン誘導体を添加することによって効果的に消失した。本法は炎症部位でのC-反応性蛋白質の役割を明らかにする上で有効な手段となるものと考えられる。
Keywords C-reactive Protein Enzyme Immunoassay
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1992-02-05
Volume volume2
Start Page 23
End Page 28
ISSN 0917-4494
language 日本語
File Version publisher
NAID 120002313528
JaLCDOI 10.18926/11786
Title Alternative Malignant diseases maifesting jaundice as a main symptom -Diagnosis and treatment to improve the poor survival in carcinoma of the bile duct and pancreatic head -
FullText URL 002_001_022.pdf
Author Mimura, Hisashi|
Abstract Primary malignant diseases manifesting jaundice as a main symptom are the carcinomas of the bile duct and the pancreatic head, both of which have very poor survival rates after surgical resection or other treatments. Statistically, unresectable cases of the diseases are absolutely fatal within one or two years. Pathologically curative resection in early stage could only give the patients a chance to survive without diseases. Role of early detection of the diseases at the primary clinics of internal physicians is essentially important, because the patients noticing jaundice would firstly visit them under the impression of having the liver deseases. They should not waste much time in examining various liver function tests. Image diagnosis on the bile duct and the pancreatic duct by ultrasonography, followed by PTC or ERCP, detect the diseases. Tumor marker, CT, MRI and angiography are also performed supplementally to determine the tumor expansion or resectability. Surgery should be the histologically curative resection, including extended skeletonization of the retroperitoneum. Recent five years' survival rates of the bile duct carcinoma after resection in all over Japan are 64.5% in stage-Ⅰ, 50.4% in stage-Ⅱ, 30.7% in stage-Ⅲ and 9.4% in stage-Ⅳ. And those of the pancreatic carcinoma are 39.3% in T(1) (within 2cm in tumor diameter), 21.3% in T(2) (2-4cm), 13.1% in T(3) (4-6cm) and 12.1% in T(4) (over 6cm). From these data, curative resection in the early stages (stage-Ⅰ or -Ⅱ in bile duct carcinoma ant T(1) or T(2) in pancreatic carcinoma) is recommended, but even in the stage-Ⅲ the chance to live longer by extended resection is preserved. To achieve furhter improvement, author has devised the NEW surgical technigues, "block resection of the hepatoduodenal ligament" for carcinoma of the bile duct and "isolated pancreatectomy" for pancreatic carcinoma. Curative resectabilities are increasing by applying these techniques and hepatic recurrence rate in pancreatic carcinoma is decreasing by "isolated pancreatectomy", although the statistical results of improvement in five years' survival rates are not yet achieved because of shortage in cases' numbers and time duration.
Keywords 黄疸 診断 治療 手術
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1992-02-05
Volume volume2
Start Page 1
End Page 22
ISSN 0917-4494
language 日本語
File Version publisher
NAID 120002313384
JaLCDOI 10.18926/11780
FullText URL 001_083_089.pdf
Author Yamamoto Hideki| Miyake Hideaki| Takahashi Yasuji| Sumimoto Tetsuhiro|
Abstract Various flow visualization techniques were applied to study the tidal exchange of the Seto Inland Sea with the largest hydraulic model in a horizontal scale 1/2000. To analyze dyefront patterns, image processing techniques have been developed. The techniques include the extraction of the boundary of the dyefront and the flow direction through tuft images.
Abstract Alternative 近年、瀬戸内海地域では過去の産業発展や人口増加に伴って発生した水質汚濁も改善されてきており、将来に向けた海の積極的利用が模索されている。水質汚濁シミュレーションを行うために建設された瀬戸内海大型水理模型も、こうした動きの中で、人為的な流動環境操作法に基づく海の有効利用を図るための手段として活用される方向にある。このような海域流動環境の制御効果を評価するためには、物質輸送に関わる流れを的確に捉えることが必要である。最近のコンピュータや画像処理技術の発展に伴って、流れの可視化で得た画像から流れの定量的な情報を求める研究が進められている。これらの研究においては、可視化手法としてトレーサ直接注入法を用いて個々のトレーサ粒子あるいはトレーサ粒子群の移動から流速ベクトル分析が求められている。筆者らはさきに瀬戸内海大型水理模型内に放流した染料の拡がりを検出するための画像処理手法について報告した。本論文では、染料とタフトを併用した可視化手法により経時的に一定間隔で得られた一連の流れパターンから、水理模型の広島県呉湾での流速ベクトル分析を求める画像解析手法と結果について述べる。
Keywords Tuft Flow Visualization Dye Visualization Seto Inland Sea Hydraulic Model
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1991-03-25
Volume volume1
Start Page 83
End Page 89
ISSN 0917-4494
language 英語
File Version publisher
NAID 120002313645
JaLCDOI 10.18926/11779
Title Alternative An approach to English culture : in the case of Lawrence Country depicted in Lady Chatterley's Lover
FullText URL 007_1_067_074.pdf
Author Takeda, Terufumi|
Abstract 世界に先駆けて産業革命を成し遂げ七つの海を支配した英国の近代機械・産業文明の発展とは反比例するかのように破壊され消滅していく自然の森林と田園。それはかつて英国の中部一帯に広がっていたロビン・フッドの活躍したシャーウッドの森とて例外ではない。そこで現在わずかに残存しているその森の一部を含めてロレンス自身が「わが心のふるさと」と呼んだ生まれ故郷イーストウッドが、彼の最後の小説『チャタリー夫人の恋人』の中にどのように採り入れられ、どのように描写されているかを考察することにより、英国文化の偉大なる伝統が如何なるものであるかのその一端なりを論じてみる。
Abstract Alternative Some of the scenes of predictive insight into the vicissitudes of England when the heroine Connie went out for a drive in Chapter 11 are quated here as a substitute for the abstract of this paper, "The car ploughed uphill through the long squalid straggle of Tevershall,... And between, in between, were the tattered remnants of the old coaching and cottage England, even the England of Robin Hood,... England, my England! But Which is my England? The stately homes of England make good photographs, and create the illusions of a connection with the Elizabethans.... This is history. One England blots out another. The mines had made the halls wealthy. Now they were blotting them out, as they had already blotted out the cottages. The industrial England blots out the agricultural England. One meaning blots out another. The new England blots out the old England...."
Keywords 英国文化 (English culture) 『チャタリー夫人の恋人』 (Lady Chatterley's Lover) D.H. ロレンスの故郷 (D.H. Lawrence Country) イーストウッド (Eastwood) 古き良き時代 (the good old days)
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1996-09-30
Volume volume7
Issue issue1
Start Page 67
End Page 74
ISSN 0917-4494
language 日本語
File Version publisher
NAID 120002313931
Author Tsuda, Toshihide| Mino, Yoshio| Matsuoka, Hiroaki| Tanihara, Shinichi| Babazono, Akira| Yamamoto, Eiji|
Published Date 1995-12-20
Publication Title 環境制御
Volume volume17
Content Type Departmental Bulletin Paper
JaLCDOI 10.18926/15518
Title Alternative Clinical significance of spa therapy in patients with steroid-dependent intractable asthma
FullText URL 065_119_127.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Takata, Ichiro|
Abstract 気管支喘息のなかでも,副腎皮質ホルモン依存性の喘息は,もっとも重症難治性であり,薬物療法のみでコントロールすることは極めて困難である。著者らの現在までの成績では,このようなステロイド依存性重症難治性喘息に対して,温泉療法は有効であった。このことは,喘息の治療,とりわけ重症難治例の治療には温泉療法が必要不可欠であることを示している。今回は,その臨床的有用性および機序について,若干の考察を加えた。1.臨床病型では,Ib型やII型に重症難治症例が多く,温泉療法はこれらの病型に対して有効であった。2.年齢別検討では,発症年齢では30才以上,また現年齢では40才以上の症例に対して温泉療法は有効であった。3.温泉療法による換気機能の改善では,小ないし細気管支領域の閉塞の改善がより高度であった。4.温泉療法により,気道過敏性が低下することが観察された。5.温泉療法により,高度に低下した副腎皮質機能の改善が見られた。5.ヨードゾル吸入,鉱泥湿布療法,温泉プール水泳ないし歩行訓練などが,喘息の治療に適した温泉療法と判断された。
Abstract Alternative It is very difficult or sometimes impossible for phisicians to control steroid-dependent intractable asthma (SDIA) without glucocorticoids because of the severity of asthma and low responsiveness to usual antiasthma drugs. Our previous studies have shown that spa therapy improves the symptoms and signs of patients with SDIA, suggesting that spa therapy is highly required for the treatment of SDIA. In this article, the effects and action mechanisms of spa therapy on SDIA were summarized according to the results previously described. 1. Spa therapy is more effective in patients with hypersecretion (type Ib) and bronchiolar obstruction (type II) than in those with simple bronchoconstriction (type Ia). 2. Spa therapy is more effective in patients with the age at onset over 30, and in those with the age over 40 years. 3. Obstructive dysfunction in small airways is more improved compared to that in medium or large airways by spa therapy for asthma patients. 4. Bronchial hyperresponsiveness of asthma patients is suppressed by spa therapy. 5. Markedly suppressed function of adrenocortical glands is improved by spa therapy. 6. Complex spa therapy including swimming training in a hot spring pool, inhalation of iodine salt solution and fango therapy is effective and clinically useful for the treatment of asthma patients.
Keywords 重症難治性喘息 (intractable asthma) 換気機能 (ventilatory function) ヨードゾル吸入 (inhalation of iodine salt solution) 鉱泥湿布療法 (fango therapy) 温泉プール水泳訓練 (swimming training in a hot spring pool)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 119
End Page 127
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307310
JaLCDOI 10.18926/15345
Title Alternative 気管支喘息の発症における加齢の影響について
FullText URL 063_142_147.pdf
Author Mitsunobu, Fumihiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Tanizaki, Yoshiro|
Abstract Skin tests, serum total IgE levels, specific IgE antibodies against each allergen, bronchial reactions provoked by allergens and histamine release from basophils are well known as prameters of immediate allergic reactions. The incidence of positive immediate skin reaction to allergens such as house dust, ragweed, Aspergillus Alternaria, Cladosporium and Broncasma decreased with aging. On the other hand, the incidence of positive skin reaction to Candida albicans was higher in cases between the age of 41 and 50 and cases over the age of 61 compared to that in the other groups classified by age. Serum IgE levels was highest in cases aged between 0 and 30. The levels of serum IgE decreased with aging. The incidence of positive RAST scores (more than 2+) and positive bronchial reaction to house dust were highest in cases between 0 and 30, and decreased with aging. However, the positive ratio of these tests against C. albicans were highest in cases between 41 and 50. The degree of histamine release from basophils of asthmatics induced by anti-IgE was consistently high without any correlation to aging when their serum IgE levels were more than 501 IU/ml. In the cases with serum IgE levels of less than 300 IU/ml, basophil reactivity to anti-IgE decreasd with aging. Basophil reactivity to house dust was generally dependent on the levels of specific IgE antibodies against the allergen. Although basophil reactivity to C. albicans was also high in cases with positive RAST scores, some cases with a RAST score of 0+ or 1+ showed high or moderate basophil reactivity. Moderate or high reactivity of basophils was frequently observed in cases between 41 and 50 and cases over age 61.
Abstract Alternative 気管支喘息の発症機序の一つとして,IgE抗体にmediateされる即時型アレルギー反応や好塩基球の反応性の関与が明らかにされている。本論文では,即時型アレルギー反応や抗ヒトIgEや特異抗原に対する好塩基球の反応性が加齢によりどのような影響を受けるかについて検討を加えた。ハウスダスト,ブタクサ,アスペルギルス,アルテルナリア,クラドスポリウム,ブロンカスマ などによる皮内反応の陽性率は,加齢とともに低下する傾向を示した。一方カンジダによる皮内反応の陽性率は,41~50歳および61歳以上の年齢層で高度であった。血清IgE値は加齢とともに低下する傾向がみられた。ハウスダスト特異的IgE抗体,吸入誘発試験の陽性率は,加齢とともに低下する傾向を示した。一方カンジダでは特異的IgE抗体,吸入誘発試験いずれも41~50歳および61歳以上の年齢層で比較的高い陽性率が観察された。抗ヒトIgEに対する好塩基球の反応性は,血清IgEが高値(501IU/ml以上)の場合は年齢と関係なくIgE依存性であったが,血清IgE値の低い症例(301IU/ml以下)では年齢が高い群でその反応性が低い症例の比率が大きかった。ハウスダストに対する好塩基球の反応性は,抗ヒトIgE同様年齢が高い群ほど反応性が低い症例の比率が大きかった。カンジダに対する好塩基球の反応性は,41~50歳および61歳以上の年齢層の症例でより高度であった。
Keywords Skin test (皮内反応) IgE Provocation test (吸入誘発試験) Basophil reactivity (好塩基球の反応性) Aging (加齢)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 142
End Page 147
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307130
JaLCDOI 10.18926/11776
Title Alternative Coping for the better quality of life(QOL) after adult kidney transplantation and factors affecting on the coping
FullText URL 007_1_049_057.pdf
Author Hayashi, Yuko|
Abstract 腎移植は、免疫抑制剤の進歩に伴う高い生存率や生着率はもちろんのこと、今日では特に移植後のQOLに焦点が当てられている。移植後のQOLを向上させていくためには、レシピエントが移植後の様々な出来事にいかに対処していくかが重要である。本研究は、腎移植後のレシピエントの対処に焦点を当て、移植後のQOLに関係する対処および対処に影響を及ぼす要因を明らかにすることを目的とした。対象者は、関東の2施設で腎移植を受けて入院および外来通院をしている20才以上の10名のレシピエントで、研究参加の同意を得た後、腎移植後どのように対処しているかや、何が対処に影響を与えているかについて面接並びに観察による調査を行った。分析の結果、腎移植後の対処は<問題と取り組む><情報の交換><問題状況の再認知>である対処様式が主に用いられており、医師に任せるという<お任せ>は全員に見られなかった。また、腎移植後の対処に影響を及ぼす要因として、<身体の状態><自己概念><不確かさ><ソーシャルサポート>が見いだされた。
Abstract Alternative Concerning kidney transplantation today, posttransplantation quality of life(QOL) is intensively focused on as well as the patients survival or the graft survival. For improving QOL of the recipients, how effectively the recipients can cope with the postoperative events is important. The purpose of this study is to know the coping ways of recipients after kidney transplantation for better QOL and clarify the factors affecting on them. The 10 patients aged 20 or more undergoing kidney transplantation in two hospitals in Kanto area were subjected for this study. They were interviewed and observed. The analyzing results showed that there were three main types of coping way ; tackling the problem, seeking the information and a new recognition of the situation. There was not the way of leaving everything to doctor. The factors affecting on their coping way were physical state, self concept, uncertainty, and social support.
Keywords 対処 (coping) 身体の状態 (physical state) 自己概念 (self concept) 不確かさ (uncertainty) ソーシャルサポート (social support)
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1996-09-30
Volume volume7
Issue issue1
Start Page 49
End Page 57
ISSN 0917-4494
language 日本語
File Version publisher
NAID 120002313679
JaLCDOI 10.18926/15343
Title Alternative 抗原および抗ヒトIgEに対する抗塩基球の反応性. 3.Ca2(+)の細胞内流入およびヒスタミン遊離
FullText URL 063_134_141.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kimura, Ikuro|
Abstract The release mechanism of chemical mediators from basophils and mast cells was discussed when these cells were stimulated by different antigens and anti-IgE. 1. Ca(2+) influx into mast cells increased after stimulation by antigen. The increased Ca(2+) uptake by mast cells was inhibited by antiallergic agents, disodium cromoglycate (DSCG) and tranilast, and calcium antagonists, nifedipine and nicardipine. 2. The dose-response curve of histamine release by antigen was different from that by anti-IgE. The maximum release of histamine by house dust was, however, similar to that by anti-IgE. House dust- and anti-IgE-induced release of histamine increased with higher- serum IgE levels. On the contrary, the release of histamine by Candida albicans was not releated to serum IgE levels, and the release by C. albicans did not parallel therelease by anti-IgE.
Abstract Alternative ハウスダスト,カンジダなどの抗原および抗ヒトIgE刺激時の,抗塩基球および肥満細胞からの化学伝達物質遊離機序について,若干の検討を行った。1.肥満細胞へのCa(2+)の流入は,抗原刺激後に増加する傾向を示した。この肥満細胞のCa(2+)取り込みの増加は,抗アレルギー剤であるクロモリン(DSCG)やトラニラストやCa(2+)拮抗剤であるニフェジピンやニカルジピンによって抑制された。2.抗原(ハウスダスト)によるヒスタミン遊離の濃度依存性カーブは,抗ヒトIgEによるカーブとは異なっていた。しかし,ハウスダストが抗原である症例では,抗原による最高ヒスタミン遊離値は,抗ヒトIgEによる遊離値とある程度の相関を示した。そして,抗原(ハウスダスト)および抗ヒトIgEによる好塩基球からのヒスタミン遊離は,血清IgE値が上昇するにつれて,増加する傾向が見られた。一方,カンジダによるヒスタミン遊離は,血清IgE値との相関は無く,また,抗ヒトIgEによるヒスタミン遊離との間にも関連は見られなかった。
Keywords Ca(2+) influx (Ca2+流入) histamine release (ヒスタミン遊離) house dust (ハウスダスト) Candida albicans (カンジダ) anti-lgE (抗ヒトIgE)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 134
End Page 141
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307872
JaLCDOI 10.18926/15338
Title Alternative Immunotherapy in house dust mite sensitive asthma
FullText URL 063_117_122.pdf
Author Okazaki, Morihiro| Kitani, Hikaru| Mifune, Takasi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honnke, Naoko| Kusaura, Yasuhiro| Tanizaki, Yoshiro|
Abstract ダニ喘息はアトピー型喘息の典型であるが,これに対する根本療法としてアレルゲンであるハウスダストを皮下注射する免疫療法が臨床でおこなわれている。70-80%の有効性が報告されているが,その作用機序はいまだ不明である。この稿においては特異的IgE抗体,特異的IgG抗体,特異的lgG4抗体,抗イディオタイプ抗体,肥満細胞の反応性,リンパ球の役割について総説する。また新たな試みとしてのallergen antibody complexを使った免疫療法,ペプタイドを使用する治療の可能性についても言及する。
Abstract Alternative Immunotherapy with house dust extract is employed as a treatment of patients with house dust mite sensitive bronchial asthma. Although 70-80% efficacy of the treatment is reported, mechanisms of its efficacy are not clear yet. In this paper, reported studies of IgE antibody, IgG antibody, IgG4 antibody, antiidiotypic antibody, reactivity of mast cells and function of lymphocytes are reviewed. A new type of immunotherapy with allergen antibody immune complex and a potential use of influenza virus hemaglutinin peptide analogue are also referred.
Keywords ダニ喘息 (House dust mite sensitive bronchial asthma) 免疫療法 (lmmunotherapy)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 117
End Page 122
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307745
JaLCDOI 10.18926/11772
Title Alternative The influence on the family caused by the mother staying away from home in order to take care of a sick child being hospitalized -six cases of siblings left at home who refused to go to school because of this situation-
FullText URL 007_1_035_039.pdf
Author Ohta, Niwa|
Abstract 母親が病気の子どもに1か月以上付き添う場合の家に残されている同胞への影響について研究を行ってきた。今回、その同胞172ケースのうちで登校拒否があった6ケースについて子どもの特徴、家族構成、家族状況等を検討した。その結果、6ケースのうち3ケースが9歳の女児であった。同居家族は1ケースで、他は核家族であった。この同胞たちは、「笑顔がなくなる」、「寂しそうな表情をする」など何らかの精神的不安を表していた。登校拒否の始まった時期は全て入院後1か月未満の時であった。登校拒否が一時的でなく、退院後にも長びいたケースは父親と女児のみが家に残されていた。このような結果から核家族が多い現在小児看護を行う場合、残された同胞への配慮を早期から行いながら病児や母親の援助を行うことが重要である。
Abstract Alternative In this study, we investigated six cases in which students refused to go to school after their mothers'staying in a hospital in order to take care of a sick brother or sister. Analysis was done mainly on the sibling's characteristics family structures and family conditions. Three of the six cases involved nine year old girls. One case involved an extended family and the others involved nuclear families. The siblings showed mental anxiety such as no longer being able to smile and/or to express loneliness. The duration of refusing to go to school had appeared within one month after the mother began to stay in the hospital and almost all of the cases were transient, having recovered before the mother came back to live at home, but one case continued even after her mother returned home. These results suggest that nurses should give appropriate advices and suggestions to the mother of a sick child being hospitalised about the care of a sibling left at home.
Keywords 付き添い 長期入院 (hospitalization) 家族状況 (mother, family) 同胞 登校拒否 (refusing to go to school)
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1996-09-30
Volume volume7
Issue issue1
Start Page 35
End Page 39
ISSN 0917-4494
language 日本語
File Version publisher
NAID 120002313617
JaLCDOI 10.18926/15337
Title Alternative Pathogenic significance of IgG and IgG(4) antibodies against Candida albicans in bronchial asthma
FullText URL 064_116_124.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke|
Abstract カレジダ特異的IgG及びIgG(4)抗体が,気管支喘息の発症病態に関与しているかどうかについて検討を加えた。カンジダ特異的IgGおよびIgG(4)抗体は, 0-30才の年齢層の症例ではアトピー性素因の強い症例で,また,31-60才の年齢層の症例ではストロイド依存性重症難治性喘息症例で,さらに61才以上の高年令の症例で,その産生亢進が観察される。これらの症例におけるIgG及びIgG(4)抗体産生は,0-30才の年齢ではアトピーとの関連で,また31-60才の年齢では副腎皮質ホルモンの長期投与と関連して,さらに61才以上の症例では加齢と関連して,細胞性免疫能が低下し,そのためカンジダの発育が促進され,その結果として,IgG及びIgG(4)抗体の産生亢進が見られることが明らかにされている。すなわち,気管支喘息におけるカンジダに対するIgG系抗体の産生亢進は,cell-mediated immunityの低下と言う共通の基盤を有しており,病因的意義とは必ずしも関連していないことを述べた。
Abstract Alternative Pathogenic significance of IgG and IgG(4) antibodies against Candida albicans was discussed in patients with bronchial asthma. An increased production of IgG and IgG(4) antibodies against Candida albicans has been observed in patients with atopic between the ages of 0 and 30, those with steroid-dependent intractable asthma between 31 and 61, and elderly patients over the age of 61. The mechanism of an increased production of IgG and IgG(4) antibodies seems to be related to atopy in patients between 0 and 30, long-term glucocorticoid therapy in those with steroid-dependent intractable asthma between 31 and 60, and aging in elderly patients over age 61. Atopy, glucocorticoid therapy and aging in general suppress cell-mediated immunity, and suppressed cell-mediated immunity increases growth of C. albicans in patient's body, leading to an increased production of IgG and IgG(4) antibodies against C. albicans. These results show that an increased production of IgG and IgG(4) antibodies against C. albicans is not always related to the pathogenesis of bronchial asthma.
Keywords カンジダ (Candida) lgG抗体 (IgG antibodies) IgG(4)抗体 (IgG(4) antibodies) アトピー (Atopy) 気管支喘息 (Bronchial asthma)
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 116
End Page 124
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307381
JaLCDOI 10.18926/11771
Title Alternative Factors Affecting Home Care of Elders Report 1. Support Expected by the Elderly and Family
FullText URL 001_061_068.pdf
Author Ono, Tsuruko| Arakawa, Yasuko| Ohta, Niwa| Nanba, Jun| Ohta, Takeo| Shimizu, Masako| Ishii, Kiyoko|
Abstract For the rapid increase of the elders in population in Japan after the 2nd world war, the arrangement of medical care for aged persons, both therapeutic and preventive, has become the serious social problem. To estimate the possibility of care at home and needs of elders and their family for public and volunteer services, questionnaire survey was carried out at Konko town in Okayama prefecture, Japan, in August 1990. More than half of the 105 elders older than 65 years and living alone (group A, 9 males and 96 females) replied to want to be cared for at home and 178 families with elders (group B) wanted to care for them at home. As for services they would wish to be offered when they would become bedridden at home, while group A wished to be visited and cared for by 'physician', 'home helper' and 'neighbor' in order of high rate group B 'physician', 'public health nurse' and 'nurse'. As for facility or assistance services, the former wanted 'purchasing, sweeping and washing', food delivery' and 'calling on' and the latter 'care consultation', 'assist of body bath' and 'economic aid'. Other supports or cares were also hopefully expected by both groups. The results shows that well-arrangement and promotion of a variety of constitional and personal support for home cares for elders in the community must be urged.
Keywords Home Care Family Care the Elderly Support
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1991-03-25
Volume volume1
Start Page 61
End Page 68
ISSN 0917-4494
language 日本語
File Version publisher
NAID 120002313467
JaLCDOI 10.18926/15332
Title Alternative 気管支肺胞洗浄液中リンパ球増多と患者年齢およびIgE系アレルギー反応との関連について
FullText URL 064_097_104.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kimura, Ikuro|
Abstract The proportion and number of lymphocytes in the airways were analyzed in 15 patients with a high proportion of lymphocytes in bronchoalveolar lavage (BAL) fluid (more than 30%) and in 17 patients with less than 20% of BAL lymphocytes. 1. Both atopic and nonatopic asthma patients with a high proportion of BAL lymphocytes were aged more than 50 years. In contrast, the age of patients with less than 20% of BAL lymphocytes ranged widely, from 29 to 63 years, in the two asthma types. 2. Age at onset of the disease, serum IgE levels, and ventilatory function test were not related to the proportion of BAL lymphocytes. 3. In patients with a high proportion of BAL lymphocytes, the mean proportion of these cells was 47.3% in atopic patients and 36.4% in non-atopic patients, i. e., there was no significant difference between the two asthma types. The absolute number of BAL lymphocytes in these patients was significantly higher in atopic (5.62×10(6)) than in nonatopic asthma (0.77×10(6)) (p<0.01). These findings show that an increased number of lymphocytes in the airways is clearly related to patient age and IgE-mediated allergic reaction.
Abstract Alternative 気管支肺胞洗浄(BAL)液中のリンパ球頻度が30%以上の15例および20%以下の17例の気管支喘息患者を対象に,BAL液中リンパ球頻度と年齢およびIgE系反応との関連について検討を加えた。1.BALリンパ球が高頻度(30%以上)を示す症例は,アトピー型,非アトピー型を問わず,50才以上の年齢層に多い傾向が見られた。一方,BALリンパ球20%以下の症例の年齢は,29-63才まで幅広く分布していた。2.発症年齢,血清IgE値,換気機能とBAL液中リンパ球頻度との間には関連は見られなかった。3.BAL液中リンパ球頻度が高い症例では,アトピー型では平均リンパ球頻度は47.3%,非アトピー型では36.4%であったが,両群間には有意の差は見られなかった。しかし,BAL液中のリンパ球の絶対数は,アトピー型(5.62×10(6))において,非アトピー型(0.77×10(6)) に比べ有意に高い値を示した(p<0.01)。これらの結果は,気道内リンパ球の増加は,患者年齢とIgE系反応と密接に関連していることを示唆している。
Keywords BAL lymphocytes patient age IgE-mediated allergic reaction bronchial asthma
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 97
End Page 104
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307637
JaLCDOI 10.18926/15327
Title Alternative Inhibitory effect of furosemide on histamine release from human basophils
FullText URL 063_095_098.pdf
Author Kitani, Hikaru| Kusaura, Yasuhiro| Honke, Naoko| Tanimizu, Masakuni| Mitsunobu, Fumihiro| Mifune, Takashi| Okazaki, Morihiro| Tanizaki, Yoshiro|
Abstract furosemideは利尿剤として知られているが,吸入することにより気道収縮に対して抑制的に作用することが近年報告されている。その抑制作用の機序を明らかにする目的で,furosemide添加による末梢血好塩基球からのヒスタミン遊離に対する抑制効果を検討した。健常人4例,アトピー型気管支喘息患者8例を対象として全血法で抗ヒトIgE刺激によるヒスタミン遊離を観察した。なお,furosemideの最終濃度は0,1,10,100μg/mlに調整して添加実験を行った。健常人,気管支喘息いずれにおいても,furosemide添加による末梢血好塩基球からのヒスタミン遊離に対する抑制効果はみられなかった。
Abstract Alternative Inhibitory effect of furosemide on histamine release from basophils induced by anti-IgE was examined in 4 healthy subjects and 8 patients with atopic asthma. The experiments of basophil histamine release were carried out by using whole blood method. The mean values of histamine release after 15 min preincubation with furosemide at various concentrations were not significantly decreased, in both healthy and asthmatic subjects compared to those of histamine release without furosemide. The results obtained here show that furosemide does not inhibit histamine release from basophils by the whole blood method.
Keywords 気管支喘息 (Bronchial asthma) フロセミド (Furosemide) ヒスタミン遊離 (Histamine release)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 95
End Page 98
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307119
JaLCDOI 10.18926/15326
Title Alternative Clinical evaluation of an endoscopic image filing system, Olympus SDF-3
FullText URL 063_074_078.pdf
Author Ochi, Koji| Miyake, Hirofumi| Matsumoto, Shuji| Seno, Toshinobu| Tanaka, Juntaro| Harada, Hideo| Mitsunobu, Fumihiro| Tanizaki, Yosiro|
Abstract 光ディスクとパーソナルコンピュータを組み合わせた内視鏡画像ファイリングシステムは電子内視鏡の画像の保存・管理,検索・再生などに威力を発揮する。今回,われわれはオリンパス社製内視鏡ファイリングシステムSDF-3を使用する機会を得たので,その有用性や問題点の検討を行った。有用性としては,①内視鏡画像を検査終了後直ちに再生し,再検討できる,②多数の項目についての検索や統計処理が可能である,③限られたスペース内で大量の画像データの一括保存・管理が可能であるなどが挙げられる。一方,問題点としては,①内視鏡再生画像は画質が劣化する,②検索機能を十分に活用するにはかなり煩雑な人力操作を必要とする,③光ディスクの清掃が必要であるなどがあげられる。本内視鏡ファイリングシステムに今後必要な改良点やその展望についても合わせて考案を加えた。
Abstract Alternative Olympus SDF-3, an endoscopic image filing system using an electronic endoscope in conjunction with a personal computer and an optical disk, has been recently developed. We evaluated the usefulness of this filing system with 449 cases of gastroduodenal endoscopy. As a result, we have found that this filing system has following advantages : (1) one can review endoscopic images immediately after endoscopic examinations ; (2) previously documented endoscopic image can be searched and reviewed in a short time ; (3) statistical analysis of documented cases is facilitated. However, it has some disadvantages as well to be improved : (1) quality of endoscopic images is deteriorated in the process of filing ; (2) putting patients' data into the filing system is time-consuming ; (3) frequent cleaning of an optic disk is required. This endoscopic image filing system needs to be further developed and refined.
Keywords 画像ファイリングシステム (image filing system) 電子内視鏡 (electronic endoscope)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 74
End Page 78
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307278
JaLCDOI 10.18926/15325
Title Alternative 気管支喘息患者における細胞性免疫,ガンジダ抗原に対する遅延型反応の抑制
FullText URL 063_069_073.pdf
Author Tanizaki, Yosiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Harada, Hideo| Ochi, Koji| Kimura, Ikuro|
Abstract Delayed cutaneous hypersensitivity towards Candida albicans was examined in 200 patients with bronchial asthma in relation to patient age and the level of total IgE. 1. Delayed skin reactivity towards C.albicans was depressed in the patients between the ages of 10 and 20 and in those over the age of 61. A significant difference was present in delayed skin reactivity between the groups of 10-20 and 41-50 years old. 2. The frequency of the patients with positive delayed skin reactivity towards C.albicans was the highest in those with low levels of total IgE (0 -100 IU/ml) and the low est in those with high levels of total IgE (over than 1001 IU/ml). The results suggest that cell-mediated immunity towards C.albicans is depressed re lating to atopics in the patients between 10 and 20 and to aging in the patients over 61.
Abstract Alternative 気管支喘息200例を対象にカンジダに対する即時型および遅延型皮膚反応を観察し,これらの皮膚反応と年令,血清IgE値との関連について検討を加えた。1. カンジダに対する遅延型皮膚反応は,10~20才の年齢層および61才以上の年齢層の症例において,その陽性率の低下が観察された。そして,10~20才の年齢層と41~50才の年齢層の症例では,両者間で陽性率の有意の差が見られた(p<0.001)。2. カンジダに対する遅延型皮膚反応の陽性率は,血清IgE値が低い(0~100 IU/ml)症例において最も高く,一方血清IgE値が高い(1001IU/ml以上)症例において最も低いという傾向が見られた。これらの結果は,カンジダに対する細胞性免疫は,10~20才の年齢層ではアトピーと,また61才以上の年齢層では加齢と関連して抑制されることを示唆するものと考えられる。
Keywords cell-mediated immunity (細胞性免疫) bronchial asthma (気管支喘息) atopics (アトピー) aging (加齢) カンジダ
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 69
End Page 73
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307949
JaLCDOI 10.18926/15324
Title Alternative 臨床所見および検査成績からのスコアーによる喘息分類の特徴
FullText URL 063_063_068.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Takatori, Akimasa| Okuda, Hiroyuki| Kimura, Ikuro|
Abstract Twenty six patients with bronchial asthma was classified by clinical symptoms and singns (clinical diagnosis), and the classification by clinical diagnosis was compared with the classification by a score calculated from clinical findings and examinations (score diagnosis). 1. Of 12 subjects with type Ia classified by clinical diagnosis, 8 cases with 0 to 49 ml/day of expectoration were evaluated as type Ia by score diagnosis. While four type Ia cases with 50 to 99ml/day of expectoration were calssified as type Ib by score diagnosis. The increased incidence of eosinophils in bronchoalveolar lavage fluid (BALF) of these four cases was similar to the incidence in type Ib cases with hypersecretion. 2. All of 6 subjects with type Ib by clinical diagnosis were estimated as type Ib by score diagnosis. 3. Of 8 cases with type II by clinical diagnosis, 7 cases were assessed as type II by score diagnosis. One case with type II by clinical diagnosis and with the score of 10 points was evaluated as questionable type II by score diagnosis.
Abstract Alternative 気管支喘息36例を対象に,臨床病態による喘息の分類(臨床診断)を試み,この分類と臨床所見および臨床検査より求めたスコアーによる分類(スコアー分類)との比較検討を行った。1.臨床分類でIa.単純性気管支攣縮型と診断された12症例のうち,1日喀痰量0-49mlの8症例は,スコアー分類では同様にIa.型と分類された。一方,1日喀痰量50-99mlの4症例はスコアー分類ではIb.型(気管支攣縮+過分泌型)と分類された。これら4症例のBALF中好酸球増多はIb.型に類似した病態であった。2.臨床診断によりIb.型に分類された6症例はいずれもスコアー診断でもIb.型と分類された。3.臨床診断によりII.型(細気管支閉塞型)と分類された8症例のうち,7症例はスコアー診断でもII.型と分類されたが,1症例はスコアー10でII.型の診断基準に合わず,questionable II.型と診断された。
Keywords asthma classification (喘息分類) bronchoconstriction (気管支攣縮) hypersecretion (過分泌) bronchiolar obstruction (細気管支閉塞) score diagnosis (スコアー診断)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 63
End Page 68
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307348
JaLCDOI 10.18926/15322
Title Alternative 高齢者健常人および気管支喘息患者におけるカンジダ特異的IgGおよびIgG(4)抗体について
FullText URL 063_058_062.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kotoh, Naoki| Tada, Shinya| Kimura, Ikuro|
Abstract Specific IgG and IgG(4) antibodies against Canadida albicans were exmined in 48 healthy and 69 asthmatic subjects to analyze the mechanism causing an increased production of these immunoglobulins. 1. The level of C.albicans-specific IgG and IgG(4) antibodies was higher, not significantly in IgG(4), in asthmatics under 30 years of age, compared with healthy subjects of the same age group. 2. Specific IgG and IgG(4) antibody levels in both healthy and asthmatic subjects showed a tendency to increase with aging, and significant difference was present between cases under 30 years and cases over 70 years of age. 3. Any difference in the production of specific IgG and IgG(4) was not observed in elderly cases older than 60 years between healthy and asthmatic subjects.
Abstract Alternative 高齢者(61才以上)の健常人48名および気管支喘息患者69例を対象に,カンジダ特異的IgGおよびIgG(4)抗体を測定し,その増加の機序について若干の検討を加えた。なお,対照としては,30才以下の健常者および気管支喘息患者を選んだ。1.カンジダ特異的IgGおよびIgG(4)抗体価は,30才以下では,健常人に比べ気管支喘息症例で高い傾向が見られ,特異的IgG抗体では両者間に有意の差が見られた(p<0.05)。2.カンジダ特異的IgGおよびIgG(4)抗体は,健常人および気管支喘息症例いずれも加齢とともに増加する傾向が見られ,71才では,30才以下の症例に比べ有意に高い抗体価を示した。3.61才以上の高齢者では,特異的IgG,IgG(4)抗体いずれにおいても,健常人と気管支喘息患者との間に有意の差は見られなかった。
Keywords Candida albicans (カンジダ特異的IgG) Specific IgG IgG(4) Bronchial asthma (気管支喘息) Aging (加齢)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 58
End Page 62
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307284
JaLCDOI 10.18926/11769
Title Alternative The Study of Nursing Care of Dying Patients and Their Families - Ritual Behaviors and Wordings of Nurses -
FullText URL 001_051_060.pdf
Author Takata, Setuko|
Abstract The purpose of this study was to obtain the basic data for the study of "Nursing care of dying patients and their families". I investigated 59 nurses working at hospitals in Tokushima know their ritual behaviors and their wordings that nurses and their families made for dying patients at moment of their death in the hospital. The results were; 1) Typically, two ritual behaviors were reported at attending patient's death. One was "Tamayobi"; calling dying patient's name to commend his soul to God or Hotoke. Other was "Matugo no mizu", giving water to dying patient to sympathy him. Few nurses didn't know "Tamayobi". Many nurses knew "Mstugo no mizu", however, only a few nurses did it in the hospital. 2) Nurses talked with their families in many ways around their last hours. This wordings included not only to explain dying patient's care, but also to alleviat the grief of their families much more.
Keywords Tamayobi Matugo no mizu
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1991-03-25
Volume volume1
Start Page 51
End Page 60
ISSN 0917-4494
language 日本語
File Version publisher
NAID 120002313482