| JaLCDOI | 10.18926/11843 |
|---|---|
| Title Alternative | Relationship between intracellular uptake of adriamycin and membrane potential in ADR resistant Ehrlich ascites tumor cells |
| FullText URL | 003_081_085.pdf |
| Author | Asaumi, Jun-ichi| Kawasaki, Shoji| Nishikawa, Koji| Shu Gao, Xian| Kuroda, Masahiro| Hiraki, Yoshio| |
| Abstract | We observed adiamycin (ADR) uptake and cellular transmembrane potential [amount of intracellular fluorescence of 3,3'- (Di-n-hexyl)- 2,2'- oxacarbocyanine iodide (NK-2280)] in ADR-resistant cells established from Ehrlich ascites tumor cells (EATC) and wild type EATC. In ADR-resistant cells, ADR uptake and the cellular transmembrane potential decreased as the degree of resistance increased. 4,4'- diisothiocyanatostilbene- 2,2'- disulfonic acid (DIDS) induced markedly decreases of ADR uptake and the cellular transmembrane potential. A good correlation was observed between ADR uptake and transmembrane potential in cultured cells. |
| Keywords | Adriamycin Cell Membrane Potential Flow Cytometry ADR-Resistant Cells DIDS |
| Publication Title | 岡山大学医療技術短期大学部紀要 |
| Published Date | 1993-01-31 |
| Volume | volume3 |
| Start Page | 81 |
| End Page | 85 |
| ISSN | 0917-4494 |
| language | 日本語 |
| File Version | publisher |
| NAID | 120002313508 |
| Author | 近藤 萬太郎| 笠原 安夫| |
|---|---|
| Published Date | 1942-01-25 |
| Publication Title | 農学研究 |
| Volume | volume33 |
| Content Type | Departmental Bulletin Paper |
| JaLCDOI | 10.18926/15315 |
|---|---|
| Title Alternative | Effects of the spring water on the dissolution of aminophylline tablet and theophylline sustained-release preparations |
| FullText URL | 064_060_064.pdf |
| Author | Mimaki, Yuichi| Fujii, Yoshihiro| Furuno, Katsushi| Gomita, Yutaka| Araki, Yasunori| Tanizaki, Yoshiro| |
| Abstract | 薬物のbioavailabilityに影響する因子の一つとして,製剤からの薬物の溶出速度が考えられる｡今回,温泉水による薬物溶出への影響を知る目的で,気管支喘息治療薬のアミノフィリン製剤およびテオフィリン徐放製剤の溶出挙動について検討した｡溶出試験は第12改正日本薬局方に従い,第1法(回転バスケット法)および第2法(パドル法)で行い,試験液を蒸留水および三朝温泉水として両者の溶出挙動を比較した｡アミノフィリン製剤では,10分後まで 温泉水の方が有意に高い溶出率を示した｡また,テオフィリン徐放製剤においても温泉水が8時間後まで蒸留水に比べて有意に高い溶出率を示した｡以上の結果より,アミノフィリン製剤およびテオフィリン徐放製剤は温泉水により薬物の溶出が促進されることか示唆された。 |
| Abstract Alternative | The dissolutions of aminophylline tablet and theophylline sustained-release preparattions in Misasa spring water were examined using the rotating basket and paddle methods. The dissolution rate of aminophylline tablet with the spring water was higher than that with distilled water from starting to 10 min after the test. In theophylline sustained-release preparations, the spring water showed a facilitation on the dissolution rate in comparison to the distilled water for 8 hours after the test. These results indicate that the spring water enhanced the releasing rates of aminophylline tablet and theophylline sustained-release preparations. |
| Keywords | 溶出試験 (Dissolutionte test) 温泉水 (Spring water) 気管支喘息治療薬 (Bronchial asthma therapeutic drug) |
| Publication Title | 岡大三朝分院研究報告 |
| Published Date | 1993-06 |
| Volume | volume64 |
| Start Page | 60 |
| End Page | 64. |
| ISSN | 0918-7839 |
| language | 日本語 |
| File Version | publisher |
| NAID | 120002307434 |
| Author | Yamanaka, Yoshikazu| |
|---|---|
| Published Date | 1995 |
| Publication Title | 岡山大学教育学部研究集録 |
| Volume | volume98 |
| Issue | issue1 |
| Content Type | Departmental Bulletin Paper |
| JaLCDOI | 10.18926/okadaironkou/60384 |
|---|---|
| FullText URL | okadaironkou_19_64_74.pdf |
| Author | 工藤 進思郎| |
| Publication Title | 岡大国文論稿 |
| Published Date | 1991-03-31 |
| Issue | issue19 |
| Start Page | 64 |
| End Page | 74 |
| ISSN | 0386-3123 |
| language | 日本語 |
| File Version | publisher |
| JaLCDOI | 10.18926/okadaironkou/60588 |
|---|---|
| FullText URL | okadaironkou_12_144_154.pdf |
| Author | 工藤 進思郎| |
| Publication Title | 岡大国文論稿 |
| Published Date | 1984-03-31 |
| Issue | issue12 |
| Start Page | 144 |
| End Page | 154 |
| ISSN | 0386-3123 |
| language | 日本語 |
| File Version | publisher |
| JaLCDOI | 10.18926/okadaironkou/60678 |
|---|---|
| FullText URL | okadaironkou_9_71_80.pdf |
| Author | 工藤 進思郎| |
| Publication Title | 岡大国文論稿 |
| Published Date | 1981-03-01 |
| Issue | issue9 |
| Start Page | 71 |
| End Page | 80 |
| ISSN | 0386-3123 |
| language | 日本語 |
| File Version | publisher |
| JaLCDOI | 10.18926/okadaironkou/60425 |
|---|---|
| FullText URL | okadaironkou_16_79_89.pdf |
| Author | 工藤 進思郎| |
| Publication Title | 岡大国文論稿 |
| Published Date | 1988-03-31 |
| Issue | issue16 |
| Start Page | 79 |
| End Page | 89 |
| ISSN | 0386-3123 |
| language | 日本語 |
| File Version | publisher |
| JaLCDOI | 10.18926/okadaironkou/60254 |
|---|---|
| FullText URL | okadaironkou_24_1_20.pdf |
| Author | 田仲 洋己| |
| Publication Title | 岡大国文論稿 |
| Published Date | 1996-03-31 |
| Issue | issue24 |
| Start Page | 1 |
| End Page | 20 |
| ISSN | 0386-3123 |
| language | 日本語 |
| File Version | publisher |
| Author | Tanaka, Hiroki| |
|---|---|
| Published Date | 2012-12-25 |
| Publication Title | 岡山大学文学部紀要 |
| Volume | volume58 |
| Content Type | Departmental Bulletin Paper |
| Author | Inada, Toshinori| |
|---|---|
| Published Date | 2000 |
| Publication Title | 岡山大学教育学部研究集録 |
| Volume | volume115 |
| Issue | issue1 |
| Content Type | Departmental Bulletin Paper |
| JaLCDOI | 10.18926/okadaironkou/60205 |
|---|---|
| FullText URL | okadaironkou_28_6_16.pdf |
| Author | 松尾 漢| |
| Publication Title | 岡大国文論稿 |
| Published Date | 2000-03-31 |
| Issue | issue28 |
| Start Page | 6 |
| End Page | 16 |
| ISSN | 0386-3123 |
| language | 日本語 |
| File Version | publisher |
| NAID | 40003941774 |
| Author | 笠原 安夫| |
|---|---|
| Published Date | 1944-05-25 |
| Publication Title | 農学研究 |
| Volume | volume36 |
| Content Type | Departmental Bulletin Paper |
| Author | 近藤 萬太郎| 笠原 安夫| |
|---|---|
| Published Date | 1943-05-25 |
| Publication Title | 農学研究 |
| Volume | volume35 |
| Content Type | Departmental Bulletin Paper |
| Author | 近藤 萬太郎| 笠原 安夫| |
|---|---|
| Published Date | 1943-05-25 |
| Publication Title | 農学研究 |
| Volume | volume35 |
| Content Type | Departmental Bulletin Paper |
| Author | 笠原 安夫| |
|---|---|
| Published Date | 1944-05-25 |
| Publication Title | 農学研究 |
| Volume | volume36 |
| Content Type | Departmental Bulletin Paper |
| Author | 近藤 萬太郎| 笠原 安夫| |
|---|---|
| Published Date | 1942-11-20 |
| Publication Title | 農学研究 |
| Volume | volume34 |
| Content Type | Departmental Bulletin Paper |
| Author | 近藤 萬太郎| 笠原 安夫| |
|---|---|
| Published Date | 1943-05-25 |
| Publication Title | 農学研究 |
| Volume | volume35 |
| Content Type | Departmental Bulletin Paper |
| Author | 近藤 萬太郎| 笠原 安夫| |
|---|---|
| Published Date | 1943-05-25 |
| Publication Title | 農学研究 |
| Volume | volume35 |
| Content Type | Departmental Bulletin Paper |
| Author | 近藤 萬太郎| 笠原 安夫| |
|---|---|
| Published Date | 1943-05-25 |
| Publication Title | 農学研究 |
| Volume | volume35 |
| Content Type | Departmental Bulletin Paper |
