JaLCDOI 10.18926/11759
Title Alternative 長期ホルマリン固定により失活したProliferating Cell Nuclear Antigen (PCNA) の免疫反応性回復条件の基礎的検討 ―マイクロウェーブ、オートクレーブの影響について―
FullText URL 007_1_009_015.pdf
Author Sakiyama, Junko| Ichimura, Mitsuko| Tohge, Hiroko| Endo, Hiroshi| Kawakami, Kaori| Kawatani, Yuki|
Abstract Using paraffin-embedded tissue sections of liver cancer obtained from autopsy which had been preserved in 10% buffered formalin solution for 6 months while PCNA immunoreactivity was lost, we examined the effects of heat processing by either microwave(MW) and autoclave(AC) in the presence of various processing solution. It appeared that AC processing took shorter time period than MW irradiation to restore equal immunoreactivity. With regard to immunoreactivity retrieval by MW irradiation,however, variation of the degree of retrieval depending on processing time was smaller than in AC, and so the stable consequences were obtained. Although AC processed tissues tended to be stained deep, prolonged processing time presented strong background staining and blurred nuclear margins which made it difficult to estimate the positive cell count. As for the effects of processing solution, there was little difference in retrieval of PCNA among 0.01 M citrate buffer (pH 6.0), saturated solution of lead thiocyanate and distilled water, but the least background staining was observed with distilled water. These observations suggest that MW irradiation of which effect of retrieval is less dependent of processing time and with the least background stainability, is superior to AC processing for PCNA immunoreactivity retrieval on formalin-fixed tissues.
Abstract Alternative 10%緩衝ホルマリンに6ヶ月間浸漬していた剖検材料(肝臓癌)のパラフィン包埋後の組織切片を用いて、ホルマリンの固定作用により失活したPCNAの免疫反応性の回復にマイクロウェーブ(MW)及びオートクレーブ(AC)による熱処理とその時用いる処理溶液が、どのような影響を与えるかについて検討した。その結果、同等の免疫反応性を回復するのには、AC処理の方がMW照射より短時間でよいことが解った。しかし、MW照射による免疫反応性回復では、処理時間による影響がAC処理に比べて少なく、安定した結果が得られた。また、PCNAの染色所見については、AC処理の方が濃く染まる傾向が見られた。しかし、処理時間が長くなるとバックグラウンドの染色性が高くなる、核の周囲ににじみ現象が見られる等の所見があり判定に困難をきたした。一方、処理溶液についてはクエン酸(0.01M pH6.0)、チオシアン酸鉛飽和溶液、蒸留水について検討を行った結果、PCNAの回復には差は認められなかったが、バックグラウンドの染色については蒸留水が最も少なかった。以上の結果により、ホルマリン固定により失活したPCNAの免疫反応性を回復するには、MW照射の方がAC処理より処理時間に関係なく安定した染色性が得られ、なおかつバックグラウンドの染色性が少ない等の点で優れていることが示唆された。
Keywords PCNA microwave (マイクロウェーブ) autoclave (オートクレーブ) immunohistological staining (免疫組織染色) formalin fixation (ホルマリン固定)
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1996-09-30
Volume volume7
Issue issue1
Start Page 9
End Page 15
ISSN 0917-4494
language 英語
File Version publisher
NAID 120002313519
JaLCDOI 10.18926/11758
Title Alternative Literature review on the adult kidney transplantation - based on nursing perspective-
FullText URL 007_1_001_007.pdf
Author Hayashi, Yuko|
Abstract 慢性腎不全の治療法の一つに腎移植がある。この文献検討の目的は、医学、精神医学、心理学、社会学ならびに看護学における腎移植に関する諸外国を含めた最近の研究論文を吟味し、今後の腎移植看護の実践や研究に必要な課題を明らかにすることである。文献検討は、看護学の立場から重要と思われる腎移植を受けた成人を対象にした研究論文を集めて、それを基に行った。その結果、腎移植は人工透析やCAPDよりもQOLを高める治療法であり、慢性腎不全患者にとっては期待が大きく関心の高い治療法であることが明確になった。また移植後に新たな身体的、心理的、精神的及び社会的な問題が生じることによって、レシピエントはストレスフルな状況にさらされやすいこと、レシピエントの効果的な対処の仕方がQOLを高めることなどがわかった。これらの知見から、腎移植看護の発展のためには、腎移植者の生活体験の意味を明らかにしたり、効果的な看護介入・教育の開発をめざした研究や、移植前から移植後を通じての継続的な看護の取り組みが今後の課題として考えられた。
Abstract Alternative Kidney transplantation is a preferable choice of therapy in the end-stage renal disease. The purpose of this review is to clarify the problems surrounding it and discuss the directions for future clinical nursing through the survey of the recent studies on the kidney transplantation. Worldwide literature concerning the nursing for the adult recipients undergoing kidney transplantation was studied. The majorty of studies were involved comparison of quality of life between transplants and dialysis populations. The results were follows.(1)) Successful transplantation recipients had the highest quality of life.(2)) The recipients however were often exposed to stressful situation due to the physical, mental, and psychosocial difficulties after transplantation.(3)) The effective coping way had to with the quality of life after transplantation. These results suggested that understanding the virtual life experiences of the recipients and researching the methods of the nursing intervention or education toward the recipients would be important for developing the high quality of life in recipients following kidney transplants.
Keywords 移植医療 腎移植 (kidney transplantation) QOL (quality of life) 対処 (coping) 腎移植看護 (nursing intervention) patient education
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1996-09-30
Volume volume7
Issue issue1
Start Page 1
End Page 7
ISSN 0917-4494
language 日本語
File Version publisher
NAID 120002313915
JaLCDOI 10.18926/15314
Title Alternative 気管支肺胞洗浄液中に一過性の好中球増多をきたしたアトピー型喘息
FullText URL 064_052_059.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Nakagiri, Yoshiyasu| Tada, Shinya| Kimura, Ikuro|
Abstract Clinical course of one asthma patient (64 years old, female), who had an increased proportion of neutrophils in bronchoalveolar lavage (BAL) fluid, was observed in relation to the proportion of BAL cells and ventilatory function. The patient had large asthma attacks two times during her clinical course for 15 months observed. 1. An increased proportion of BAL neutrophils and suppression of ventilatory function were found after her first large asthma attacks. The increased proportion of BAL neutrophils continued for more than 5 months. A reduction in the proportion of BAL neutrophils was found 3 months after her second large asthma attack, accompanied by improvement of clinical symptoms and ventilatory function. The numbers of total cells and neutrophils in BAL fluid were also reduced. Transient increase in number of BAL lymphocytes was found 13 months after the first large attack when the number of BAL neutrophils was markedly decreased. The number of BAL eosinophils did not change during her clinical course.
Abstract Alternative 経過中に気管支肺胞洗浄(BAL)液中に一過性の好中球増多が観察されたアトピー型喘息症例について,若干の臨床的観察を加えた。症例は,64才の女性で,臨床症状,および血清IgE高値,ハウスダストに対するIgE抗体陽性などから,アトピー型喘息と診断された。なお,経過観察し得た15ヵ月の間に2回の大発作が観察された。1.第1回の大発作後,BAL液中好中球増多と換気機能の低下が観察された。そして,このBAL液中好中球頻度は明らかな改善が見られた。BAL液中の総細胞数および好中球の絶対数も徐々に減少傾向を示し,好中球頻度と同様,第2回目の大発作3ヵ月後には著明な減少が観察された。同時にこの時期には,BAL液中リンパ球の増加も見られた。しかし,BAL液中好酸球数は15ヵ月の経過観察中ほとんど変化は見られなかった。
Keywords Bronchial asthma (気管支喘息) transient BAL neutrophilia(一過性BAL液中好中球増多) ventilatory function (換気機能)
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 52
End Page 59
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307805
JaLCDOI 10.18926/15313
FullText URL 063_034_038.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Kimura, Ikuro|
Abstract The serum levels of total IgE, IgG and IgG(4) were compared among five age groups of patients with bronchial asthma. 1. The level of serum IgE was significantly higher in the patients before the age of 29 than in those between the ages of 30 and 49 (p < 0.02), between 50 and 59 (p < 0.01) and between 60 and 69 (p < 0.01). The serum IgE level tended to increase in the patients over age 70. 2. The serum level of total IgG was significantly higher in the patients over age 70 compared with the level in the 30-49 (p < 0.05) and the 60-69 year old groups (p < 0.05). 3. The serum IgG(4) level was increased with aging, although no significant difference was found among the five age groups. 4. The IgG(4) level correlated to a certain extent with the level of serum IgE. The results reveal that the levels of total IgE, IgG and IgG(4) are increased in the elderly patients over age 70, and that there is a relationship between serum levels of total IgE and IgG(4).
Keywords Total IgE IgG IgG(4) aging bronchial asthma
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 34
End Page 38
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307767
JaLCDOI 10.18926/11757
Title Alternative Lipid Peroxides (TBA reactive substances)and Fatty Acid Compositions in Mouse Serum with Whole-body Irradiation and in Tumor-bearing Mouse Serum with Local Irradiation
FullText URL 001_029_037.pdf
Author Yamamoto, Goki|
Abstract Effects of irradiation on lipid peroxides of mouse serum, Ehrlich solid tumor-bearing mouse serum, which tomor cells were transplanted to the leg, and its tumor tissue were studied by a thiobarbituric acid (TBA) color reaction in the acetic acid condition with (Fe-TBA value) or without (TBA value) ferrous ammonium sulfate. TBA reactive substances were caluculated into the amount of malondialdehyde. Besides, fatty acid and lipid compositions were analyzed as a substrates. Irradiated samples were isolated at 3 days after irradiations. The TBA value of normal mouse serum was expressed 17nmoles/ml of serum, and Fe-TBA value gave 2.4-fold of the TBA value. Although an increase TBA value was not observed by whole-body irradiation, a significant increase of Fe-TBA value was measured, indicating 2.5-fold at 10Gy exposure compared with the normal Fe-TBA value, and 5.5-fold with the TBA value. The TBA value of tumor-bearing mouse serum was 14nmoles/ml as a low rate to that of normal serum, but the Fe-TBA value gave same magnification of that of normal one. The TBA value of tumor-bearing mouse serum was not changed by the local irradiation to the tumor region of leg, but the Fe-TBA value was increased 2.8 and 4.4 times at 10Gy and 20Gy exposures, respectively, comparing with the non-irradiated one, and 7.7 and 10.5 times with the TBA value, respectively. The TBA value of solid tumor homogenate exhibited 1.16nmoles/mg of protein, and the Fe-TBA value, pointed out 5 times as much as the TBA value. Both values slightly increased by the irradiation. These facts suggest that a shift of TBA value of serum hard to get, but Fe-TBA value of serum distinctly increases by the irradiation. The fatty acid composition of mouse serum lipids showed an increment of relative percentages of linoleic and arachidonic acids by the whole-body irradiation. The relative percentage of fatty acid compositon of lipids from solid tumor-bearing mouse serum was similar tendency to that of normal one, and the local exposure to the tumor part was not affected the each percentage. The percentage of high unsaturated fatty acid of tumor lipids similar to that of serum lipids, and a decrease of the percentage of arachidonic acid was accounted by the irradiation. In relative percentages of lipid compositions, the percentage of choleste rolester of serum lipids increased by the whole-body irradiation, and that of phospholipid fraction was not changed. In the case of tumor-bearing mouse serum lipids, an increment of the percentage of cholesterolester was obtained as compared with that of normal serum lipids, and this percentage decreased by the local irradiation to tumor part with an increment of the percentage of phospholipid. The percentage of phospholipid in tumor lipids had decreased by the irradiation. The facts suggest that a cause of the increased Fe-TBA value of tumor-bearing mouse serum by the irradiation to tumor is due to the release of peroxidizable phospholipid into serum from the damaged menbranes of tumor cells at large doses to exposure.
Abstract Alternative 放射線照射に伴うマウス血清、大腿に移植形成させたEhrlich固定癌担癌マウス血清並びにその固型癌部組織の過酸化脂質の変化を酢酸酸性下、チオバルビツル酸発色法(TBA値)及びニ価鉄添加発色法(Fe-TBA値)で測定し、チオバルビツル酸反応陽性物質(TBARS)としてマロンジアルデヒド(MDA)に換算し評価した。合わせて過酸化反応基質としての脂肪酸組成と脂質組成を解析した。正常マウス血清のTBA値は本条件下で17nmoles MDA/ml値が得られ、Fe-TBA値はTBA値の2.4倍が得られた。全身照射によるTBA値の増加はみられなかったが、Fe-TBA値は半致死線量以上で明らかな増加がみられ、10Gy照射群で正常血清Fe-TBA値の2.5倍、TBA値に対し5.5倍が示された。担癌マウス血清のTBA値は14nmoles/mlで若干正常値に比し低値が得られたが、Fe-TBA値正常同様の倍率2.5倍値が示された。担癌マウス血清のTBA値は癌部10、20Gy局所照射により変化はみられなかったものの、Fe-TBA値は線量依存的に著しい増加がみられ、10Gyで対照値の2.8倍、20Gyで4.4倍値、TBA値に対し各7.7倍、10.5倍が得られた。固型癌部組織のTBA値は蛋白質当り1.16nmoles/mgが測定され、Fe-TBA値はTBA値の5倍であった。癌部照射でTBA値、Fe-TBA値とも若干の増加がみられた。これらのことから放射線照射によりTBA値の変化はみられ難いがFe-TBA値は増加することが示唆される。血清脂肪酸組成比では、全身照射によりリノール酸、アラキドン酸の増加がみられた。担癌血清脂肪酸組成比は正常のそれと同様であり、局所20Gy照射で変化はみられなかった。癌部組織の脂肪酸組成比においては、高級不飽和脂肪酸比は血清のそれと大差なかったが飽和脂肪酸比の変化が得られた。局所照射によりアラキドン酸比の減少がみられた。脂質組成比では、全身照射により血清のコレステロ-ル比の増加がみられたがリン脂質比は変化がみられなかった。担癌血清では正常に比し、コレステロールエステル比の増加がみられたが、局所照射により減少し、リン脂質比の増加が得られた。癌部組織の脂質組成比では照射によりリン脂質比の減少とトリグリセリド比の増加がみられた。これらのことから癌部局所照射により脂質過酸化反応の主たる基質としての過酸化物を含む細胞膜成分リン脂質の血清への流出が示唆され、これが癌部局所照射に伴う血清Fe-TBA値増加の一原因と考えられる。
Keywords Lipid peroxides Irradiation Mouse serum Tumor-bearing mouse serum Fatty acid composition
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1991-03-25
Volume volume1
Start Page 29
End Page 37
ISSN 0917-4494
language 日本語
File Version publisher
NAID 120002313903
JaLCDOI 10.18926/15312
Title Alternative 老年者気管支喘息における気道炎症細胞.喘息重症度と関連した気道細胞反応の特徴
FullText URL 064_083_088.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Nakagiri, Yoshiyasu| Harada, Hideo| Kimura, Ikuro|
Abstract Cellular composition of bronchoalveolar lavage (BAL) fluid was examined in 11 elderly asthmatics over the age of 70, and the results were compared with those of 11 younger asthmatics under the age of 50. In the subjects with mild asthma, the proportion of BAL cells in the elderly subjects was 86.2% macrophages, 11.0% lymphocytes, 1.9% neutrophils, 0.9% eosinophils and 0.08% basophilic cells. The proportion of neutrophils and eosinophils in the BAL fluid was slightly higher in younger subjects with mild asthma compared with that in elderly subjects, although no significant difference was found between the two groups. In subjects with severe asthma, the proportions of lymphocytes, neutrophils, eosinophils and basophilic cells were more increased in both younger and older patients compared to those with mild asthma, and a significant increase in the number of BAL eosinophils was found in younger subjects with severe asthma compared to those with mild asthma (p < 0.05). However, no significant difference was present in the proportion of BAL cells between younger and older patients with severe asthma. The results reveal that BAL cells are more increased in subjects with suvere asthma than in those with mild asthma in both younger and older subjects, and show the possibility that this increase is more predominant in neutrophils in older subjects and in eosinophils in younger subjects.
Abstract Alternative 70才以上の老年者気管支喘息11例(平均年齢71.4才)を対象に,重症度と気道細胞反応との関連について検討を加えた。なお,対照として50才以下の喘息症例11例(平均年齢33.5才)を選んだ。1.老年者の軽症型喘息における気管支肺胞洗浄(BAL)液中の出現細胞の頻度は,マクロファージが86.2%,リンパ球が11.0%,好中球が1.9%,好酸球が0.9%,好塩基性細胞が0.08%であった。BAL液中の好中球,好酸球の頻度は若青年症例でやや高い傾向が見られたが,両群間に有意の差は見られなかった。重症例では,老年症例,若青年症例とも,軽症例に比べリンパ球,好中球,好酸球などのBAL細胞の出現頻度が増加しており,特に好酸球では若青年症例の重症例で軽症例に比べ有意に高い頻度が観察された。これらの結果は, リンパ球,好中球,好酸球などのBAL細胞は,軽症例に比べ重症例で増加してくること,そして,その増加は老年症例では好中球,若青年症例では好酸球の増加が特徴的であることを示唆しているものと考えられた。
Keywords Neutrophils (好中球) Eosinophils (好酸球) Bronchoalveolar lavage (気管支肺胞洗浄) asthma severity (喘息重症度)
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 83
End Page 88
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307736
JaLCDOI 10.18926/11754
Title Alternative On Club Activity in School -Especially Those Related with the Tokubetsu Katsudo-
FullText URL 001_011_018.pdf
Author Jin, Fumio|
Abstract Judzing from this, club activities must be included not in school education but in adult education. And so club activities in school must be practiced from the point of adult education. It seems, however, that the accepter has not been prepard yet. For the reason, It is impossible to exclude club activities at once from school education. From this point, the system of life-long education must be made up promptly and club activities are preferable to be separated from school education. On both sides of school education and adult education, the administrative readjustment must be excuted first of all for the activities of school clubs being pushed forward. It seems, however, that the problems are in Shido-yoryo itself: especially how to deal with Tokubetsu-katsudo is the problem. In other words, Shido-yoryo says, "Tokubetsu-katsudo must be separated from adult education" or "It is not practiced necessarily in adult education" in one time and "It has been applied corresponding to Bukatsu instead of Kurabu" in another time. Shido-yoryo has influenced greatly on the activities in school education.
Keywords 学校教育 学習指導要領 特別活動 クラブ活動 部活
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1991-03-25
Volume volume1
Start Page 11
End Page 18
ISSN 0917-4494
language 日本語
File Version publisher
NAID 120002313632
JaLCDOI 10.18926/11753
Title Alternative The effects of various fixating buffer soution in the electron microscopic observations
FullText URL 006_055_061.pdf
Author Akatsuka, Kazuya|
Abstract 生物学的あるいは生化学的な緩衝液を使用して作製された電子顕微鏡試料と従来の電子顕微鏡用として使用されている緩衝液で作成した試料とで電子顕微鏡像から比較検討した。HEPES緩衝液で作製した試料の電子顕微鏡像は、従来の電子顕微鏡に用いられている緩衝液で作製した試料から得られた電子顕微鏡像と非常によく似た像を示し、このHEPES緩衝液は電子顕微鏡の固定用緩衝液として使用できることが認められたが、その他(PIPES、MOPS緩衝液)の緩衝液ではあまりにも細胞内の可溶性物質が溶出しすぎて使用に耐えなかった。電子顕微鏡学研究において使用されうる固定用緩衝液は細胞内のオルガネラの保持が余りにも良い場合には、その微細構造の解析が困難になり、程々に細胞内の可溶性物質が溶出した方が解析がし易くなると思われ、この様な観点から、今回使用したHEPES緩衝液は生物学的あるいは生化学的な研究から引き続き電子顕微鏡用の試料を作製する際、同じ緩衝液が使用できることが認められた。
Abstract Alternative The effects of buffers fixating biological or biochemical materials on the ultrastructures of intracellar organera were examined in electron microscopic observations. HEPES buffers were evaluated for retention of the ultrastructures intracellular organella in comparison with PIPES, and MOPS buffers. It has been shown that the image of electron microscopic observations resembled closely to ordinary fixating buffers (Millonig, Sorencen, and cacodylate buffers) for electron microscopic materials. On PIPES buffers, the image of electron microscopic observations was indistinct because too much intracellular soluble sabstances were remained in cells. On the electron microscopic study, it may be suitable to make materials adequately permeable by removing intracellular soluble substances with buffers. In this point of view, HEPES buffers can be used as a fixating buffer in electron microscopic observations.
Keywords 電子顕微鏡 (electron microscopy) 微細構造 (ultrastructure) 肝細胞 (liver cell) カコジル酸緩衝液 (cacodylate buffer) HEPES緩衝液 (HEPES buffer)
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1996-02-29
Volume volume6
Start Page 55
End Page 61
ISSN 0917-4494
language 日本語
File Version publisher
NAID 120002313640
JaLCDOI 10.18926/11752
FullText URL 001_007_009.pdf
Author Tongu Yasumasa| Bayoumi Magdi Abdel Hamid| Saida Haruo|
Abstract マンソン住血吸虫とビルハルツ住血吸虫に混合感染し、しかも尿からマンソン住血吸虫の虫卵を検出した珍しい症例。患者は18才の男子でスーダンのハルツーム市在住。3年前に流行地で水に接する機会があった。最近、朝の最初の尿で血尿が出るようになった。また腰痛および吐気も自覚するようになった。1990年7月26日個人のクリニックで検査したところ尿の沈渣中より2種類の住血吸虫卵を検出した。スーダンでは混合感染者の3~5%に尿からマンソン住血吸虫卵が検出されるといわれているが確実な報告例はない。
Keywords Schistosoma mansoni S.haematobium schistosomiasis Sudan
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1991-03-25
Volume volume1
Start Page 7
End Page 9
ISSN 0917-4494
language 英語
File Version publisher
NAID 120002314060
JaLCDOI 10.18926/15311
Title Alternative 抗原および Ca ionophore A23187 刺激時におけるアトピー型気管支喘息末梢血好塩基球の運動能
FullText URL 064_043_051.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Ochi, Koji| Harada, Hideo| Nakagawa, Saburo| Soda, Ryo| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract We examined histamine release and morphological changes in basophilic granulocytes from atopic subjects, in response to stimulation with antigen and Ca ionophore A23187. 1. Histamine release and a reduction in the rumber of basophils were more rapid and greater in extent at an early stage of antigen stimulation compared with Ca ionophore A23187 stimulation. 2. Morphological changes in basophils, represented by increased motility, in terms of an increased ratio of short to long axis diameter (L/S ratio), as well as the increased frequency of basophils with localized granules and those with pseudopods, were more often observed antigen stimulation than with Ca ionophore A23187 stimulation. In contrast, morphogical changes in which basophils appeared swollen, showing an increased mean cell diameter and an increased frequency of cells with 5 vacuoles or more were more predominant with Ca ionophore A23187 than with antigen stimulation. The results obtained here show that bridging of IgE receptors is essential to activate basophils and induce increased motility in these cells.
Abstract Alternative アトピー型気管支喘息末梢血好塩基球を用い,抗原および Ca ionophore A23187 刺激時のヒスタミン遊離およびその形態的変化について比較検討した。1.抗原刺激時には, Ca ionophore A23187 刺激時に比べ,好塩基球からのヒスタミン遊離および好塩基球数の減少の程度は,より急激でかつ高度であった。2.好塩基球の形態的変化,すなわち,長経/短経比の増大,限局性顆粒あるいは偽足を有する好塩基球の出現頻度の増加などの運動能の亢進を示唆する好塩基球の形態的変化は, Ca ionophore A23187 に比べ抗原刺激時により高度であった。一方,平均直径の増大,5個以上の空砲を有する好塩基球の出現頻度の増加などの,むしろ膨化傾向を示唆する好塩基球の形態的変化は,抗原刺激時に比べ, Co ionophore A23187 刺激時により高度であった。これらの結果より,抗原刺激によるIgE受容体のbridgingが,好塩基球を活性化し,運動能の亢進をひき起こすものと判断された。
Keywords histamine release (ヒスタミン遊離) increased basophil motility (好塩基球の運動能の亢進) bridging of IgE receptors (LgE 受容体) antigen (抗原) Ca ionophore A23187
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 43
End Page 51
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307677
JaLCDOI 10.18926/11750
Title Alternative Total Skin Electron Beam Therapy
FullText URL 001_001_006.pdf
Author Nakagiri, Yoshitada| Inamura, Keiji| Miyake, Hideaki| Tahara, Seiji| Mimura, Seiichi| Egusa, Tomomi| Mikami, Yasutaka| Yamada, Toshiharu| Sugita, Katsuhiko| Hiraki, Yoshio|
Abstract The peripherally T-cell lymphoma; Mycosis fungoides etc, has the good radiation sensitivity, and has been adapted for total skin electron beam therapy. In this study the pendular irradiation method was used for the purpose of total skin electron beam therapy in Mycosis fungoides, and physical data on the radiation field and the electron beam energy were useful clinically.
Abstract Alternative 皮膚に限局した一連の末梢型T細胞リンパ腫は放射線に対する感受性が高く、電子線治療の適応となる疾患である。こららの疾患は一般的に全身の皮膚に浸潤するため、治療に際してはTarget Volumeの深さに合わせた最小限のエネルギーで全身隈なく照射する必要がある。筆者等は最近臨床で遭遇した菌状息肉症の患者を治療するため、その患者に合った物理的なデータを測定した。照射野の拡大には振子照射法を用い、エネルギー低減方法は装置に装備されている鉛のスキャタラーを低原子番号で、しかも加工のしやすい塩化Vinyl板に交換する方法を工夫した。データとして治療効果、副作用に関係する線量率、エネルギー、及び照射野内平坦度について測定した結果、距離が長くなる関係から線量率が低下する全身照射法の欠点は解消できなかったが、エネルギー及び平坦度については使用可能なデータを得ることができた。
Keywords 電子線全身照射法 菌状息肉症 全身性皮膚疾患
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1991-03-25
Volume volume1
Start Page 1
End Page 6
ISSN 0917-4494
language 日本語
File Version publisher
NAID 120002313887
JaLCDOI 10.18926/15310
Title Alternative 気管支喘息の臨床分類とその細胞性および液性因子の特徴
FullText URL 064_036_042.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Nakagiri, Yoshiyasu| Tada, Shinya| Kimura, Ikuro|
Abstract Characteristics of each asthma type classified by clinical symptoms and findings were studied in 72 patients with bronchial asthma. 1. Ventilatory function tests showed that the values of % MMF, % V(50) and % V(25) were significantly lower in patients with bronchiolar obstruction (type II) compared to the values of those with simple bronchoconstriction type (type Ia) and those with bronchoconstriction + hypersecretion (type Ib). 2. The proportion of neutrophils in bronchoalveolar lavage (BAL) fluid was significantly higher in type II than in type Ia and type Ib. Several patients with type Ib showed higher proportion of BAL eosinophils. 3. The release of LTC(4) from leucocytes was significantly lower in type II compared with type Ia and type Ib. There was no significant difference in the release of histamine and LTB(4) among the three asthma types.
Abstract Alternative 気管支喘息72例を対象に,その臨床病態の特徴を,気道炎症性の細胞および化学伝達物質の観察により検討した。1.気道反応の特徴を換気機能の面から検討すると,II細気管支閉塞型において,MMF,V(50)やV(25)などの小ないし細気管支領域の換気障害を示すパラメーターの値は,Ia型,Ib型に比べ 有意の低下を示した。2.気道細胞反応では,II型において,他の臨床病型に比べ,BAL液中好中球の出現頻度の有意の増加が観察された(Ia, p<0.001 ; Ib, p<0.01)。好酸球の出現頻度は,Ib過分泌型において著しい増加傾向を示す症例が見られたが,その平均出現頻度には3病型間に有意の差は見られなかった。3.好中球からのメジェー夕ー遊離では,ヒスタミン遊離は,Ia単純性気管支撃縮型において最も高い値が示されたが,推計学的には3病型間に有意の差は見られなかった。ロイコトリエンC(4)では,Ia型においてII型に比べ有意に高い遊離が観察された(p<0.05)。ロイコトリエンB(4)遊離には,3病型間に差は見られなかった。
Keywords Bronchial asthma Asthma classification BAL fluid chemical mediators
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 36
End Page 42
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307662
JaLCDOI 10.18926/11749
Title Alternative メキシコ肺吸虫のセルカリアはどれか?
FullText URL 010_2_063_067.pdf
Author Tongu, Yasumasa|
Abstract The true cercaria of Paragonimus mexicanus is the cercaria reported by Malek et al. in 1985 as a cercaria of P. peruvianus. However, there is a question whether the flame cell formula of 2〔(3+3+3+3+3)+(3+3+3+3+3)〕=60 is justified. Therefore, I question the possibility of the cercaria of P. mexicanus reported by Ito et al. in 1985. If it has a pseudo-sucker, it belongs to another species of Paragonimus cercaria. The cercaria reported by Tongu et al. in 1990 from Venezuela was eliminated the possibility of a new species. It is probable that this cercaria belongs to P. mexicanus. Ibanez revived the name of P. peruvianus in 1990 by the differences in the cercaria and adults. However, I disagree with his opinion.
Abstract Alternative メキシコ肺吸虫の真のセルカリアは実験方法から考察して,Malekらが1985年にペルー肺吸虫のセルカリアとして報告したものである。ただしそのflame cell式は信用できない。したがって伊藤らが1985年にメキシコ肺吸虫として報告してきたセルカリアは,事実pseudo-suckerが存在するならば別種のセルカリアと考えられる。また頓宮らが1990年に報告したベネズエラ産肺吸虫のセルカリアは侵入腺の数を見誤った可能性もあり,メキシ コ肺吸虫のセルカリアの可能性が強い。Ibanezはメキシコ産肺吸虫とペルー産肺吸虫の成虫における違いからペルー肺吸虫の名前の復活を主張したが,それは適当ではない。成虫における内部器官の違いはむしろ種内の変異と捉えるべきである。
Keywords Paragonimus mexicanus (メキシコ肺吸虫) Paragonimus peruvianus (ペルー肺吸虫) cercaria (セルカリア) taxonomy (分類) Latin America (中南米)
Publication Title 岡山大学医学部保健学科紀要
Published Date 2000-03-24
Volume volume10
Issue issue2
Start Page 63
End Page 67
ISSN 1345-0948
language 英語
File Version publisher
NAID 120002313440
JaLCDOI 10.18926/15309
Title Alternative Correlations between bone mineral density measured by QCT and risk factors of Osteoporosis
FullText URL 063_030_033.pdf
Author Honke, Naoko| Kusaura, Yasuhiro| Tanimizu, Masakuni| Mitsunobu, Fumihiro| Mifune, Takashi| Okazaki, Morihiro| Kitani, Hikaru| Tanizaki, Yoshiro| Takatori, Akimasa| Okuda, Hiroyuki| Nakai, Mutsuro| Akiyama, Tsuneo|
Abstract 27~85才の女性143例における骨塩量を,定量的QCT法 (quantitative computed tomography)を用いて測定し,年令,身長,体重及び原疾患(慢性関節リウマチ),使用薬剤(ステロイド・骨強化剤)の因子の骨塩量に及ぼす影響について検討した。その結果,1)加令とともに骨塩量は低下するが,特に40才代後半から60才代にかけての低下が顕著であり,また, 他因子の影響を受けやすい。2)体型的因子としては.痩せ型で低身長の人に低値の傾向がある。3)ステロイド使用の有無における検討において,特に50才代で使用群が著明に低値であることが明らかとなった。また,薬剤の因子の考察に関しては,さらに経時的検討か必要であると思われた。
Abstract Alternative Bone mineral density (BMD) was measured in 143 females aged 27 to 85 years old to investigate the correlations between BMD and several factors such as age, height, presence of rheumatoid arthritis and corticosteroid or bone intensifying drug therapy. 1) BMD values decreased with aglng and the most remarkable decrease was observed at the age of latter half of 40's to 60's. 2) Women with slim and low stature tended to have low BMD values. 3) BMD values of women with steroid therapy were significantry lower than those without corticosteroid at the age of 50's (p<0.01). However, further study is necessary to confirm the effect of drugs on BMD.
Keywords 骨粗鬆症 (Osteoporosis) 定量的コンピューター断層法 (QCT (quantitative computed tomograpy))
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 30
End Page 33
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307603
JaLCDOI 10.18926/15308
Title Alternative 老年者気管支喘息における液性および細胞性免疫反応について
FullText URL 064_075_082.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Ochi, Koji| Harada, Hideo| Tada, Shinya| Kimura, Ikuro|
Abstract Humoral and cellular immune responses in bronchial asthma were examined by comparing the results of older asthmatics (group OA) with those of older healthy subjects (group OH) and of younger asthmatics (group YA). In humoral immune response, IgE-mediated immune system expressed by elevated serum IgE levels and IgE antibodies for house dust mite (HDm) and/or Candida albicans was clearly found in older asthmatics, while there was no finding showing the presence of IgE-mediated immune response in older healthy subjects. There was no significant difference in levels of serum IgG and IgA among the three groups. However, the serum IgM level was significantly lower in older asthmatics than in younger asthmatics. IgE antibodies to HDm and/or Candida albicans were more frequently found in older asthmatics compared with older healthy subjects. In contrast, IgG(4) antibodies to HDm were not different among the three groups. IgG(4) antibodies to Candida albicans were significantly higher in both older groups than in younger group. However, there was no significant difference between asthmatic and healthy subjects in the elderly. Delayed skin reaction to PPD was significantly more decreased in older asthmatics. These results show that bronchial asthma in the elderly is characterized by the presence of IgE-mediated immune response and by the changes of immune response with aging.
Abstract Alternative 気管支喘息における液性および細胞性免疫反応について,老年者気管支喘息,老年者健常人,および若年者気管支喘息の間で比較検討を行った。1.まず,液性免疫では,血清IgE値高値,ハウスダストやカンジダに対するIgE抗体陽性などのIgE系反応は,老年者気管支喘息においては明らかに観察されたが,老年者健常人では全く観察されなかった。血清IgGおよびIgA値には3者間に有意の差は見られなかったが,血清IgMは,若年者喘息に比べ老年者喘息で有意に低い値を示した。2.ハウスダストやカンジダに対するIgE抗体は老年者喘息において老年者健常人に比べより高い頻度で陽性であったが,一方,ハウスダストに対するIgG(4)抗体は3者聞に有意の差は見られなかった。また,カンジダに対するIgG(4)抗体は,老年者喘息および健常人において,若年者喘息に比べ有意の高値を示した。しかし,老年者の喘息と健常人との間には有意の差は見られなかった。3.PPDによる遅延型皮膚反応は,若年者喘息に比べ老年者喘息において有意の減弱傾向を示した。これらの結果は,老年者喘息はIgE系反応を有していること,そして,加齢による免疫反応の変化の影響を受けること,を示している。
Keywords IgE IgG(4) Immunoglobulings (免疫グロブリン) PPD Bronchial asthma (気管支喘息) 加齢
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 75
End Page 82
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307261
JaLCDOI 10.18926/11739
Title Alternative Nursing care brought behavioral change on a hemodialysispatient, whose body weight increased conspicuously
FullText URL 010_1_057_061.pdf
Author Uchida, Yoko| Hayashi, Yuko|
Abstract 体重増加が著しく,嘔気や嘔吐を繰り返していた透析患者が,看護婦とのかかわりの中で,徐々に体重コントロールが出来るように変化していった。そこで,透析患者に行動変容をもたらした看護援助が何であったのかを明らかにすることを目的として,本事例を振り返り,Banduraの「自己効力理論」と,河口らの,行動変容への「とっかかり言動」の概念に基づいて考察した。その結果,患者に行動変容をもたらした看護援助は以下のようであることがわかった。(1)患者の気持ちや行動を受け止め,共感することで,患者が感情表出しやすい環境を整えた。(2)患者の行動変容に結びつく言動を逃さずキャッチした。(3)「それぐらいならできそう」という,患者にとって身近で実行可能な行動目標を共に考えた。(4)患者が成功体験を積み重ねることが出来るように,患者を支援し,行動を評価して,患者の自己効力を高めた。
Abstract Alternative The purpose of this study is to clarify what a nursing care brought some changes in a hemodialysis patient's behavior. Based on Bandura's self-efficacy theory and on a concept of "speech and action for clue" proposed by Kawaguchi et al, the nursing care was discussed. The results were as follows : (1) Nurses made positive environments in which for the patient to express his emotion frankly through nurse's acceptable and empathic manner. (2) Nurses appropriately caught the patient's speech and action as clue to change in his behavior. (3) Nurses helped the patient consider his behavioral objectives that he can carry out by himself. (4) Nurses supported the patient and evaluated his behavior, and helped him succeed in his task so that he could improve his self-efficacy.
Keywords 透析患者 (hemodialysis patient) 行動変容 (behavioral change) 看護援助 (nursing care)
Publication Title 岡山大学医学部保健学科紀要
Published Date 1999-12-20
Volume volume10
Issue issue1
Start Page 57
End Page 61
ISSN 1345-0948
language 日本語
File Version publisher
NAID 120002313703
JaLCDOI 10.18926/15307
Title Alternative 気管支喘息におけるハウスダストアレルギー. 血清IgE値とIgE抗体価と年齢との関連
FullText URL 064_031_035.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Ochi, Koji| Harada, Hideo| Tada, Shinya| Kimura, Ikuro|
Abstract Serum IgE levels and IgE antibody values in relation to patient age were examined in 50 patients with house dust mite (HDm) sensitive asthma, 1. IgE antibody values to HDm were highest in patients between the ages of 10 and 19, and the values generally low in those over the age of 40. 2. High IgE antibody values to HDm were accompanied by high serum IgE levels in patients between 10 and 19. IgE antibody values and serum IgE levels were in general low in patients over age 40. In patient under age 9, serum IgE levels were less than 500 IU/ml in 5 of the 10 subjects despite an increased value of IgE antibodies to HDm. These results suggest that an increased production of IgE antibodies to HDm is usually accompanied by an increased production of total IgE in younger subjects. However, an increase in production of IgE antibodies is not always related to an increase in production of total IgE in patients under age 9. The results also show that production of IgE antibodies to HDm and total IgE is in general low in older patients despite the hyperreactivity to HDm.
Abstract Alternative ハウスダストが原因抗原であるアトピー型気管支喘息50例を対象に,血清IgE値とIgE抗体価を年齢との関連のもとに検討した。1.IgE抗体価は10-19才の年齢層の症例において最も高く,一方40才以上の症例では全般的に低い傾向が見られた。2.10-19才の年齢層の症例では,IgE抗体価の高値と同時に血清IgE値も高い値を示したが,40才以上の症例では,IgE抗休価および血清IgE値いずれも10-19才の症例に比べ全般的に低い値を示した。9才以下の症例では,IgE抗体価の高値にもかかわらず,血清IgE値は比較的低く,500IU/ml以下を示した症例が10例中5例に観察された。これらの結果は,若年症例では,IgE抗体の産生亢進と総IgEの産生亢進が同時に見られること が多いが,9才以下ではIgE抗体産生亢進に総IgE産生亢進が必ずしもともなわない場合があることを示している。また,40才以上の症例では,ハウスダストに対する過敏性は有しているものの,IgE抗体価および血清IgEは全般的に低い値を示す傾向が示唆された。
Keywords Serum IgE (血清IgE) IgE antibodies (IgE抗体) house dust mite (ダニ) bronchial asthma (気管支喘息)
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 31
End Page 35
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307674
JaLCDOI 10.18926/11736
Title Alternative Percentage body fat and results of a periodic health examination
FullText URL 006_023_028.pdf
Author Ohta, Takeo| Goto, Akio| Masaki, Hisako| Takami, Yoko|
Abstract 肥満や栄養過剰は多くの慢性疾患、とりわけ成人病と関連が強いことが従来から指摘されている。肥満の判定には体脂肪率を測定することが重要であるが、その方法の一つとして、集団検診に使用しやすい生体電気インピーダンス法(bioelectrical impedance analysis)がある。今回、1ビール製造工場の定期健康診断において、対象者男235人および女137人の体脂肪率をこの方法により測定した。まずこの体脂肪率とBMIおよび肥満度との相関関係を求め、男性より女性において相関が高いことを認めた。ついで肥満群と正常群に分けて、血圧および血液検査の異常率の出現頻度を統計的に比較したところ、肥満群では男女共に総コレステロールで、また男性では尿酸、γGTP、SGPTの各値で、異常者が高率であることを認めた。またSGPTは30才台から、γGTP及びTchは40才台からその傾向が見られた。しかし、肥満指数とこれらの検査値との相関係数は高くはなかった。
Abstract Alternative Data from periodic health examinations such as ALP, UA, RBC, Hb, SGOT, SGPT, Tch(total choresterol), TG(triglyceride), blood pressure, body length, body weight and also percentage body fat(% Fat) as measured by bioelectrical impedance mehtod were obtained from 235 male and 137 female workers at a brewery factory in Okayama Prefecture and results were analyzed. The correlation coefficients for % Fat and Body Mass Index values(BMI) are found to be 0.678 for males and 0.803 for females. Examinees were then devided into normal and obesity groups respectively, and the frequency of values over normal ranges (classified by obesity indicators such as % Fat, BMI and obesity rate calculated from standard weight) were statistically compared. Results showed that % Fat and BMI were more sensitive than obesity rate and that the obesity group had statistically high frequencies of abnormality in some of the data as in the case of SGPT, γGTP and TG compared to the control group. Furthermore this tendency was found to be more significant among male workers than female ones.
Keywords 体脂肪率 (percentage body fat) インピーダンス (bioelectorical impedance) BIA 健康診断 (periodic health examination) BMI
Publication Title 岡山大学医療技術短期大学部紀要
Published Date 1996-02-29
Volume volume6
Start Page 23
End Page 28
ISSN 0917-4494
language 日本語
File Version publisher
NAID 120002313771
JaLCDOI 10.18926/15306
Title Alternative 気管支喘息における気道内への好中球の出現とその意義 換気機能と関連して
FullText URL 063_025_029.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuharu| Kimura, Ikuro|
Abstract Ventilatory function was compared between two age-matched asthma groups : group A (study group) consists of 8 patients with bronchial asthma with marked neutrophilia (20% or more) in the BAL fluid and group B (control group) of 8 patients with neutrophils (less than 5% of total BAL cells). The values of six ventilatory parameters were lower in group A than in group B, and a significant difference was found in FEV(1.0%), % MMF, % V(50) and % V(25) between groups A and B. Of these parameters, the value of % V(25) was markedly decreased in group A compared with group B. The results show that ventilatory dysfunction in airways, especially in small airways, is closely correlated to increased number of neutrophils in BAL fluid.
Abstract Alternative 気管支喘息を対象に,年令をmatchさせた2つのグループ,すなわち,気管支肺胞洗浄液(BALF)中の好中球の出現頻度が20%以上の8症例(グループA)と,BALF中の好中球の出現頻度が5%以下の8症例(グループB)における換気機能について比較検討を行った。6つの換気パラメーターは,全般的にグループAにおいてグループBに比べ低い傾向が見られ,FEV(1.0%),% MMF,% V(50)および% V(25)値は,いずれもグループAにおいて有意に低い値が示された。これらのパラメーターのうち,% V(25)値はグループBに比べグループAにおいて著明に低い値が示された。これらの結果は,気道における換気障害,特に小ないし細気管支領域の換気障害は,BALF中の好中球の出現頻度とある程度関連していることを示すものと考えられた。
Keywords ventilatory function (換気機能) neutrophils in BAL fluid (好中球, BAL) small airways (細気管支) bronchial asthma (気管支喘息)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 25
End Page 29
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307993
JaLCDOI 10.18926/11734
Title Alternative Analysis of three cases of renal transplant recipients whose feelings about life have become negative after transplantation
FullText URL 010_1_051_056.pdf
Author Watanabe, Kumi| Hayashi, Yuko| Nakanishi, Yoshiko| Kanao, Naomi| Hosina, Eiko|
Abstract 筆者らは,林が作成した看護援助モデルに基づき,腎移植者への効果的な看護介入についての検討を行っている。その一環として,今回,腎移植を受けた119名を対象に,QOLや移植前と現在の人生に対する受けとめ方について調査した。人生に対する受けとめ方の移植前後の変化を分析したところ,ほぼ全数に近い腎移植者が移植前と比べよい状態であると受けとめていたが,3事例において受けとめ方が低下していた。そこで,この3事例に着目し,これらの事例が日常生活の中で不満を抱いている事柄を分析した。その結果,移植後に人生に対する受けとめ方が低下した3事例が抱く不満は,1.腎臓・健康などの身体状況,2.家庭環境,3.医療・友人・他人からのサポート,4.家族や社会の中で役割を果たす能力の4カテゴリーに分類された。移植後の人生の受けとめ方の否定的変化には,上記の4カテゴリーに対して抱く不満が影響していることが推測され,腎移植後の看護介入を検討する上で考慮すべき点であることが明らかになった。
Abstract Alternative We are seeking an effective nursing intervention for renal transplant recipients based on a nursing support model described by Hayashi. Among 119 patients we investigated, at least 90% of them experienced increased positive feelings about their lives after receiving a renal transplant, whereas three of them answered differently. The purpose of this study is to analyze the complaints of three recipients after renal transplantation. Factors such as age, gender, marital status, time-course after transplant, and type of kidney transplant are included in the study. As a result, their complaints are differentiated into 4 categories : (1) status of transplanted kidney and their own health, (2) status of medical support, or assistance from their friends and others, (3) situation of their immediate family, (4) a grade of their ability to fulfill their social and familial responsibilities. These results are important in our nursing approach in order to improve the quality of life (QOL) of renal transplant recipients.
Keywords QOL (quality of life) 腎移植 腎移植者 (renal transplant recipient) 看護 (nuising approach)
Publication Title 岡山大学医学部保健学科紀要
Published Date 1999-12-20
Volume volume10
Issue issue1
Start Page 51
End Page 56
ISSN 1345-0948
language 日本語
File Version publisher
NAID 120002313642