JaLCDOI 10.18926/fest/11646
FullText URL 001_205_210.pdf
Author Tsuboi, Sadao| Ono, Shin-ichiro| Utaka, Masanori|
Abstract Chiral reduction of 2-oxosuccinic acid esters with fermenting bakers' yeast gave (S)-(-)- malic acid esters in 34-54% isolated yield with 85-100% ee.
Keywords optically active malic acid balers' yeast asymmetric reduction α-ketoester.
Publication Title 岡山大学環境理工学部研究報告
Published Date 1996-03
Volume volume1
Issue issue1
Start Page 205
End Page 210
ISSN 1341-9099
language 英語
File Version publisher
NAID 120002313572
JaLCDOI 10.18926/15161
Title Alternative Clinical studies on polypoid lesions of the colon.
FullText URL 065_101_106.pdf
Author Takata, Ichiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Matsumura, Tadashi| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Akiyama, Tsuneo| Nakai, Mutsuo|
Abstract 1990年4月より1994年3月末までの間に岡山大学医学部附属病院三朝分院で経験した早期大腸癌を含む大腸ポリープ88例を対象に,病理組織診断,性別,年齢構成,存在部位,精査動機について検討を行い,以下の成績を得た。(1)ポリープの69.2%は腺腫,13.2%は腺癌(早期癌)であった。(2)男女とも加齢による大腸ポリープ及び大腸癌の頻度の増加がみられた。(3)50歳未満の若年者では右側結腸にポリープが発見されることは稀であったが50歳以上では6.5%に認められ,高齢者における積極的なtotal colonoscopyによる観葉が重要であることが再確認された。(4)精査動機では便潜血陽性が最多を占め,便潜血は大腸ポリープのスクリーニングにおいて有用であることが示された。またフォローアップ目的に大腸ファイバーを施行しポリープや早期癌を発見した例も多く,フォローアップの必要性が示唆された。
Abstract Alternative Polypoid lesions, taken by a colon fiberscope, were examined in 88 patients with polyp, who were admitted to Misasa Medical Branch, Okayama University Medical School for last 4 years. (1) Pathohistological examination of the polypoid lesions resulted in 69.2% of adenoma and 13.2% of adenocarcinoma (early cancer) ; (2) 35.5% of the polypoid lesions was detected in the sigmoid colon, 32.7% in the rectum, 16.8% in the transverse colon, 4.7% in the descending colon, 3.7% in the caecum, 1.9% in the ascending colon ; (3) The number of patients with polypoid lesion or colon cancer was increased with aging ; (4) Patients with the age under 50 years did not have polypoid lesion in the right hemicolon, while 6.5% of elder patients over age 50 has polypoid lesions in the right hemicolon ; (5) Occult blood in stool was the most popular motivation for receiving colonoscopic examinations ; (6) The second popular motivation for colonoscopy was for follow up after previous examinations. These results suggest that patients with age over 50 should be examined more carefully by total colonoscopy, and a hemoccult test in stool is an effective method for screening colonic polypoid lesions and after detection of polypoid lesions or polypectomy, reexamination by total colonoscopy is important at regular intervals.
Keywords 大腸ポリープ (Polyp of the colon) 大腸早期癌 (Early cancer of the colon) 便潜血 (Occult blood in stool)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 101
End Page 106
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307396
JaLCDOI 10.18926/11643
Title Alternative Prevalence of urinary stress incontinence in women
FullText URL 062_023_026.pdf
Author Okuda, Hiroshi| Takatori, Akimasa| Izushi, Michihiro| Yoshida, Junko| Yamagami, Keiko| Sakata, Junko| Tanizaki, Yoshiro|
Abstract 三朝分院外来を訪れた女性患者を対象に尿失禁に関する18項目のアンケート調査を行った。その結果,全体の過半数が尿失禁の経験者であった。腹圧性尿失禁が大部分を占め,高齢になるほど 経産回数が多いほど頻度が高くなる傾向がみられた。そのうちの約1割に尿漏れの頻度と程度が重かった。以上より,尿失禁について積極的な啓蒙,診断,治療の必要性が認められた。
Abstract Alternative The prevalence of urinary stress incontinence was investigated in 93 women consulting in our hospital by means of a questionnaire survey. The survey showed that 52.7% of the total cases experienced the loss of urine. 87% of the cases with the loss of urine were the cases with stress incotinence. The prevalence of incontinence increased with age up to 69.2% in the 60's. A positive correlation was found between the number of childbirths and the prevalence of incontinence.
Keywords 腹圧性尿失禁 (Urinary stress incontinence)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 23
End Page 26
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313351
JaLCDOI 10.18926/15160
Title Alternative A case report of mixed connective tissue disease.
FullText URL 065_096_100.pdf
Author Takata, Ichiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Matsumura, Tadashi| Yokota, Satoshi| Tanizaki, Yoshiro|
Abstract 症例は50歳女性で,1991年頃より両肘関節の疼痛とレイノー現象を自覚するようになり前医にて慢性関節リウマチ(Rheumatoid arthritis, 以下RAと略)との診断を受け加療受けるも症状の改善なく,当科を受診した。典型的な慢性関節リウマチの症状に乏しく,他の膠原病の存在を疑って検索したところ,抗RNP抗体陽性等の所見から,混合性結合組織病(mixed connective tissue disease, 以下MCTDと略)と診断した。MCTDは初診時に慢性関節リウマチと誤診される例が多く,慢性関節リウマチに非典型的な症状を伴う場合は,MCTDが鑑別診断として重要と考えられた。
Abstract Alternative A 50-year-old woman, diagnosed as rheumatoid arthritis (RA) in 1991, had been treated with Lobenzarit disodium and non steroidal anti-inflammatory drugs (NSAIDs) before administration at our hospital. Despite the treatment with these drugs, her symptoms did not improve. She was admitted to our hospital for her progressive bilateral elbow joint pain and Raynaud's phenomenon. Although abnormal values of laboratory examinations such as an increased ESR (64mm/1hr), increased level of serum IgG (2854mg/㎗) and a positive RA test were shown, the clinical features of classical RA were not clear. There, she was diagnosed as mixed connective tissue disease (MCTD), because of high level of anti-RNP antibody in serum, Raynaud's phenomenom, multiple arthritis and constrictive ventilatory disturbance. Her symptoms and the results of labolatory examinations were clearly improved by glucocorticoid therapy.
Keywords 混合性結合組織病 (MCTD) 慢性関節リウマチ (Rheumatoid arthritis) 抗RNP抗体 (Anti-RNP antibody)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 96
End Page 100
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307772
JaLCDOI 10.18926/15159
Title Alternative Effects of salbutamol and disodium cromoglycate on Specific Airway Resistance (sRaw) and Specific Conductance (sGaw) in Bronchial asthma and Rheunmatoid arthritis.
FullText URL 065_087_095.pdf
Author Yokota, Satoshi| Kitani, Hikaru| Mifune, Takashi| Kajimoto, Kazuhiro| Mitsunobu, Fumihiro| Takata, Itiro| Tanizaki, Yoshiro| Tada, Shinya| Harada, Mine|
Abstract サルブタモールまたはdisodium cromoglycate(クロモリン)吸入液を,気管支喘息(以下BA)6例,慢性関節リウマチ(以下RA)7例,正常対照5例に吸入させ,吸入前および吸入後約30分に,気道抵抗(sRaw)と気道コンダクタンス(sGaw)を,定容積型体プレチスモグラフ(Sensor Medics Corporation, Anaheim, California, made in U.S.A.)を用いて測定した。吸入前の値をsGawで比較すると,BAはRAや正常対照に比べ有意に閉塞の程度が強く,RAと正常対照の間では有意な差はなかった。サルブタモール吸入の場合,BAでは吸入後にsRawおよびsGawの有意な改善(P<0.01)がみられ,それらの改善率(%)は,RAや正常対照と比べて有意に高く(P<0.01),RAと正常対照の間では改善率の有意な差は認めなかった。クロモリン吸入の場合,いずれの群においても,sRawおよびsGawの吸入後の変化に有意差はみられなかったが,BAにおいて,sRawの改善率(%)はRAと正常対照に対して,またsGawの改善率(%)は正常対照に対して有意に高く(P<0.05),RAと正常対照の間では,sRaw,sGaw共に改善率(%)の明らかな差はみられなかった。
Abstract Alternative We examined effects of salbutamol sulfate and disodium cromoglycate (cromolyn) on specific airway resistance (sRaw) and specific conductance (sGaw) in 6 patients with bronchial asthma (BA), 7 patients with rheumatoid arthritis (RA), and 5 subjects of controls, using a constant volume, whole body plethysmograph (Sensor Medics Corporation, Anaheim, California, U.S.A.). The results before and 30 minutes after inhalation of agents were compared to evaluate their effects on sRaw and sGaw. Before inhalation, the sGaw of BA was significantly lower than that of RA or controls, and there was no difference between that of RA and normal controls. The sGaw and sRaw in BA were significantly improved (P<0.01) after inhalation of salbutamol and those improvement after inhalation were significantly higher (P<0.01) in BA than those in RA or controls, however there was no difference between those of RA and controls. Although there was no sigificant change of sGaw and sRaw in all groups between before and after inhalation of cromolyn, the improvement of sRaw after inhalation was significantly higher in BA than in RA or controls (P<0.05), and that of sGaw was significantly higher in BA than in controls (P<0.05).
Keywords 気道抵抗 (sRaw) 気道コンダクタンス (sGaw) 気管支喘息 (bronchial asthma) 慢性関節リウマチ (rheumatoid arthritis) 気管支拡張作用 (the effect of bronchodialation)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 87
End Page 95
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307239
JaLCDOI 10.18926/15156
Title Alternative Study on the relatjonship between the bone mineral density mesured by QCT and the osteoporosis therapy.
FullText URL 065_069_076.pdf
Author Kajimoto, Kazuhiro| Takata, Ichiro| Yokota, Satoshi| Mitsunobu, Fumihiro| Mifune, Takashi| Kitani, Hikaru| Tanizaki, Yoshiro| Kobayashi, Yasuaki| Nakagiri, Yoshiyasu| Nakai, Mutsuro| Akiyama, Tsuneo|
Abstract 当院通院あるいは入院中の女性患者54例を対象に骨塩量を経時的に3回測定し検討を行った。54例の骨塩量の平均は3回とも有意差はなく,年次骨塩変化量は-3.1±14.6mg/cm(3)/yearであった。平均骨塩量の年齢別比較では40才台,50才台,60才台の順に有意な減少がみられ,60才台と70才以上との間には差は認めなかった。また50才台及び70才以上の年代で1年当たりの骨塩量の減少が大きい傾向が窺われた。身長と骨塩量との間に有意の正の相関を認めたが,体重との間には有意の相関を認めなかった。血清中Ca,P及びALPと骨塩量との検討ではいずれも有意の相関を認めなかった。骨塩変化量減少群と増加群との比較では,平均骨塩量及び背景因子の間に差を認めなかった。女性,特にステロイド療法を必要とする患者については閉経の時期にあたる40~50才台より積極的に骨粗髭症対策を考える必要性があると考えられた。また運動療法については温泉プール療法自体を再検討するとともに,骨粗髭症に特異的な運動療法の確立が必要と思われた。
Abstract Alternative Bone mineral densities (BMD) were mesured 3 times in 54 females aged 40 to 84 years old to evaluate about relationship between BMD and osteoporosis therapy or patient background factors. BMD decreased 3.1±14.6mg/cm(3) per year, and BMD values were more decreased in subjects with the age of 50's and over 70's than in those with the age of 40's and 60's. In patients with bronchial asthma or rheumatoid arthritis, treated with corticosteroids (predonisolone : 3-7.5mg/day), BMD were sigfnificantly more decreased than in patients without corticosteroid therapy. There was a significant positive correlation between BMD and body height, but no correlation between BMD and body weight, serum Ca, P, or alkaline phosphatase. No differences in background factors were found between subjects with increased BMD and those with decreased BMD. These results indicate that female patients with corticosteroids need active treatments for the prophylaxis of osteoporosis at the age of 40's or 50's.
Keywords 骨粗鬆症 (Osteoporosis) 骨塩量 (Bone mineral density) 運動療法 (Exercise therapy) QCT (quantitative computed tomograpy)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 69
End Page 76
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307602
JaLCDOI 10.18926/15155
Title Alternative MASTシステムによる気管支喘息患者の特異的IgE抗体の検討
FullText URL 065_062_068.pdf
Author Mitsunobu, Fumihiro| Kitani, Hikaru| Mifune, Takashi| Kajimoto, Kazuhiro| Yokota, Satoshi| Takada, Ichiro| Tanizaki, Yoshiro|
Abstract The serum levels of specific IgE antibodies to food allergens and inhalant allergens were evaluated in ninety five patients with bronchial asthma using the MAST system, which can measure specific IgE antibodies against sixteen different allergens with a single sample. 1. Higher positivities of specific IgE antibodies were found in inhaled allergens than in food allergens. Specific IgE antibodies against several allergens were detected in individuals more frequently in inhaled allergens than in food allergens. 2. Positivities of specific IgE antibodies against food allergens did not correlate to patients' age and patients' age at onset. In inhaled allergens, positive results in MAST system were frequently observed in patients under age of 50 and under age at onset of 60. 3. In subjects with high serum IgE levels, high positivities of specific IgE antibodies against inhaled allergens and food allergen were found. 4. The MAST system is suggested to be clinically more useful than RAST.
Abstract Alternative 気管支喘息95例を対象に,MASTシステムにより吸入抗原,食餌抗原の陽性率を検討した。その結果,吸入抗原の方が食餌抗原よりも陽性者が高率にみられ,さらに複数個の抗原に陽性の傾向が見られた。また8名の食餌抗原陽性者の内7名が吸入抗原陽性であった。MAST陽性率と年令,発症年令には食餌抗原では明らかな相関は見られなかったが,吸入抗原では,50才以下の症例に陽性率がやや高い傾向が,発症年令が60才以下の症例の陽性率が高い傾向が見られた。食餌抗原では血清IgE値が300IU/ml以上の症例で陽性者がみられ,1001IU/ml以上の症例では66.7%と比較的高率であった。一方,吸入抗原に対する陽性率は,血清IgE値が500IU/ml以上の症例で高く70%以上の陽性率であった。以上の結果より1検体同時多項目(16項目)測定可能なMASTシステムは従来のRASTに比して臨床的に有用であると考えられた。
Keywords bronchial asthma (気管支喘息) specific IgE antibodies (特異的IgE抗体) MAST system (MASTシステム)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 62
End Page 68
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307337
JaLCDOI 10.18926/fest/11630
Title Alternative Process of Acid Sulfate Soil Formation from the Viewpoint of Moisture Conditions on Coastal Muddy Soil and a trial of it's Amelioration
FullText URL 001_135_141.pdf
Author Adachi, Tadashi|
Abstract According to recent soil survey data, it has been reported that acid sulfate soils cover areas of about 11,670,000 hectares all over the world and about 40% of those are in South-East Asia. Most of crops could not be grown on those areas without any amelioration due to low soil pH. This report consists of two parts. One is on acid sulfate soil formation in laboratory experiment. Another is on a trial of acid sulfate soil amelioration in field experiment. The results obtained on acid sulfate soil formation, in order to make clear the relationships between the process of oxidation of sulfur compounds and the moisture conditions (moisture suction) in coastal muddy soils, in laboratory experiment are summarized as follows; The concentration of sulfuric ions increase as oxidation of sulfur compounds contained in pyrite, etc. occurs, and as a consequence, the soil pH decreases in the coastal muddy soil (Fig.1). Especially, the soil pH decreased remarkably in the range of pF 2.3~3.4. The activity of soil microorganism takes part in this reaction by helping out with bringing about sulfur oxidation and formation of sulfuric ions. The pH decrease in the soil with autoclaved treatment was only slight at pF values lower than pF 3.0. Accordingly, it is concluded that the decrease of pH in coastal muddy soil occurred mainly due to soil microorganisms which oxidize sulfur compounds under the condition of higher-water than pF 3.0. The results of field experiment is summarized as follows; As a general rule, it is able to remedy the surface acidification of peat/acid sulfate soils by mixing lime dust with plough layer. However, the effect of mixed lime dust is easily disappeared in the area where the acidic ground water table is always high and moves up over the surface in rainy season. Therefore, it was carried out that several experiments for seeking protection against surface acidification due to capillary upward movement of acidic ground water by means of inserting a buffering layer of lime gravel (thickness of lime gravel layer =5㎝) between the top soil and the acidic subsoil (20 ㎝ depth) in the fields, Munoh series which is young acid sulfate soil, at the Narathiwat Land Development Center in South Thailand. The results of soil pH measurement carried out in the field in November of 1985, August of 1987 and September of 1990, it coincides with 2,4 and 7 years respectively after the beginning of the experiments, are shown in Table 3. In the plot of P2 and U1, application of lime dust to the plough layer can increase soil pH rapidly but it's residual effect is not so long. Within a 5 year period, the soil pH is likely to return to below 4. On the other hand, an underlaid lime gravel layer tends to improve the soil around the lime gravel only slight but steadily with time. Therefore, it is concluded that surface soil acidification caused by the upward movement of acidified ground water would be protected against, rapidly and continuously, by both mixing lime dust with plough layer and underlying lime gravel below plough layer. If acid sulfate soil areas would be used as upland fields, much of organic matters in soil are easily decomposed by drying. Therefore, it is suggested that it would be better for these areas to be used as paddy fields, also from the above results.
Keywords Acid sulfate soil Soil microorganisms Moisture conditions Amelioration pH Sustainable effect
Publication Title 岡山大学環境理工学部研究報告
Published Date 1996-03
Volume volume1
Issue issue1
Start Page 135
End Page 141
ISSN 1341-9099
language 日本語
File Version publisher
NAID 120002313380
JaLCDOI 10.18926/15154
Title Alternative 気管支喘息における血清免疫グロブリン値,末梢血リンパ球数と気管支肺胞洗浄液中の細胞成分との関連
FullText URL 065_055_061.pdf
Author Mitsunobu, Fumihiro| Kitani, Hikaru| Mifune, Takashi| Kajimoto, Kazuhiro| Yokota, Satoshi| Takata, Ichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Tada, Shinya| Harada, Mine|
Abstract Changes in airway inflammation by glucocorticoids were examined in 26 patients with bronchial asthma, divided into two age groups ; 20-59 and 60+ years, in relation to serum immunoglobulin levels and peripheral lymphocyte count. 1. The levels of IgG, IgA and IgM were significantly lower in patients with steroid-dependent intractable asthma (SDIA) of age over 60 years than in those with non-SDIA of the same age group. In patients between the ages of 20 and 59, only serum IgG level was significantly lower in SDIA than in non-SDIA patients. 2. Peripheral lymphocyte count was significantly decreased in SDIA patients than in non-SDIA patients in age group over 60, but not in age group between 20 and 59. 3. Number of lymphocytes in bronchoalveolar lavage (BAL) fluid was significantly lower and number of BAL neutrophils was significantly higher in SDIA patients than in non-SDIA patients in age group over 60, but not in age group between 20 and 59. These results suggest that levels of IgG, IgA and IgM, and peripheral lymphocyte count were significantly suppressed in SDIA patients of age over 60, accompanied with decrease of BAL lymphocytes and increase of BAL neutrophils.
Abstract Alternative 気管支喘息26例(ステロイド依存性重症難治性喘息,SDIA 13例,非SDIA 13例)を対象に,血清免疫グロブリン,IgG,IgAおよびIgM値,および末梢血リンパ球数との関連のもとに,副腎皮質ホルモン長期投与による気道炎症細胞の出現頻度の変化について検討を加えた。なお,年齢による影響を観察する目的で,SDIAおよび非SDIA各13例を,20-59才と60才以上の2群に分けて,それ ぞれのグループの特徴について検討した。1.血清IgG,IgAおよびIgM値は,60才以上の症例において,いずれも非SDIA症例に比べ,SDIA症例で有意に低い値を示した。一方,20-59才の症例群においては,IgG値のみSDIA症例で有意の低下傾向が見られた。2.末梢血リンパ球数は,60才以上の症例では,SDIA症例で,非SDIA症例に比べ有意の低値を示したが,20-59才の症例では両群間に有意の差は見られなかった。3.気管支肺胞洗浄(BAL)液中のリンパ球数 は,60才以上のSDIA症例で,非SDIA症例に比べ有意に少なく,また同時にこれらの症例ではBAL液中好中球が有意に多い傾向が観察された。しかし,20-59才の症例群では,SDIAと非SDIAの間にいずれも有意の差は見られなかっ た。これらの結果より,60才以上の症例では,20-59才の症例群に比べ,副腎皮質ホルモンの長期投与により,血清IgG,IgAおよびIgM値,末梢血リンパ球数の減少とともに,BAL液中のリンパ球減少,好中球増加をきたしやすいことが明らかにされた。
Keywords serum immunoglobulin levels (血清免疫グロブリン値) lymphocytes (リンパ球) neutrophils (好中球) bronchial asthma (気管支喘息) glucocorticoids (副腎皮質ホルモン)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 55
End Page 61
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307607
JaLCDOI 10.18926/fest/11626
FullText URL 001_151_162.pdf
Author Ndegwa George Maina| Yomota, Atsushi|
Abstract Actual irrigation situation in a typical upland irrigation district was estimated by the water balance method during the 1993 rainy and the 1994 dry year periods. Soil moisture conditions were analysed for cases where daily district water use was supplied to all the cropped upland farms, and to reduced irrigation area percentages. Consumptive use was obtained through monthly weighted crop coefficients used to reduce penman's potential evapotranspiration. The moisture budget was examined at three levels of total readily available moisture, TRAM, i.e., 20,30 and 40 mm; the effect of upward capillary rise was also considered. The results of this study indicated that the actual moisture conditions in upland irrigated farms is influenced by irrigation area, cropping pattern, stage of crop growth and upward capillary rise in the farms. Actual irrigated area was within the range of about 44 to 100% of cropped area while upward capillary rise was between 0.1 and 1 mm day-1, TRAM level of 30 to 40 mm was considered most appropriate for the district. Monthly effective rainfall percentages from the water balance method were fairly close to that determined by the basic irrigation requirement method for some months. Basic irrigation requirement may therefore be considered to incorporate capillary water contribution.
Keywords Upland irrigation TRAM Water balance Capillary water Effective rainfall
Publication Title 岡山大学環境理工学部研究報告
Published Date 1996-03
Volume volume1
Issue issue1
Start Page 151
End Page 162
ISSN 1341-9099
language 英語
File Version publisher
NAID 120002313861
JaLCDOI 10.18926/15153
Title Alternative Clinical feature of bronchial asthma in relation to patient age
FullText URL 065_048_054.pdf
Author Mifune, Takashi| Takata, Ichiro| Yokota, Satoshi| Kajimoto, Kazuhiro| Mitsunobu, Fumihiro| Kitani, Hikaru| Tanizaki, Yoshiro|
Abstract 高齢気管支喘息症例の病態を解明するために30才以降の気管支喘息症例について年齢層別に臨床的特徴を検討した。1)60才以上の高齢気管支喘息症例は全体の41.1%を占めており,年齢層別では50-59才,60-69才の症例が多く認められた。2)ほとんどの症例が成人発症喘息であり,高齢気管支喘息では92.3%が中高年発症型気管支喘息であった。3)加齢に伴って細気管支閉塞型気管支喘息の増加か認められた。4)血清IgE値は50-59才で再増加し,histamine release,LTC(4)産生は40149才で高値であった。5)40-69才の年齢層でステロイド依存性難治性喘息が多く認められた。以上高齢気管支喘息症例は中高年発症型喘息の病態の特徴を有しており,中高年発症型気管支喘息の病態の解明が必要と考えられた。
Abstract Alternative To examine clinical characteristics of asthma in elderly (over 60 years), age at onset, clinical asthma types, glucocorticoid therapy, serum IgE levels and release of chemical mediators (histamine and leukotriene C(4)) were examined in 145 asthmatics over 30 years and divided into five age groups ; 30-39, 40-49, 50-59, 60-69, 70-79 years. 1. The freqeuncy of asthmatics was 13.7% in age group between 30 and 39, 14.4% between 40 and 49, 30.8% between 50 and 59, 28.8% between 60 and 69, 12.3% between 70 and 79 years, respectively. The frequency of elder asthmatics (over age 60) was 41.1%. 2. The frequency of adult onset asthma (over 20 years) was 90.3% of all subjects, and the frequency of late onset asthma (over 40 years) was 92.3% of elderly subjects over age 60. 3. Numbers of asthmatics with bronchiolar obstruction type show a tendency to increase with aging. 4. Serum IgE level was increased in subjects aged 50-59 years. Histamine release (%) and release of leukotriene C(4) from peripheral leukocytes were higher in age group between 40 and 49 compared to those in the other age groups. 5. Number of patients with steroid-dependent intractable asthma was increased in age group between 40 and 69. These results suggest that elderly asthmatics show the characteristics of late onset asthma, and further examinations of late onset asthma is important to clarify the pathogenesis of asthma in elderly.
Keywords 高齢気管支喘息 (bronchial asthma in elderly) 中高年発症型喘息 (late onset asthma) 臨床病態 (clinical types of asthma) ステロイド依存性重症難治性喘息 (steroid dependent intractable asthma) ケミカルメディエーター (chemical mediator)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 48
End Page 54
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307608
JaLCDOI 10.18926/15152
Title Alternative ステロイド依存性重症難治性喘息における気道反応の特徴
FullText URL 065_040_047.pdf
Author Mifune, Takashi| Kitani, Hikaru| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Takata, Ichiro| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Tada, Shinya| Harada, Mine|
Abstract Characteristics of airway response in steroid-dependent intractable asthma (SDIA) were examined in 86 asthma patients (43 with SDIA and 43 with non-SDIA) divided into three age groups: 20-39, 40-59 and 60+ years, by observing cellular composition of bronchoalveolar lavage (BAL) fluid and ventilatory function. 1. The level of serum cortisol was significantly lower in patients with SDIA than in those with non-SDIA in all age groups. 2. The proportion of lymphocytes in BAL fluid was significantly decreased in patients with SDIA compared to results in non-SDIA patients in the age between 40-59, and over 60+ years, While BAL neutrophils were significantly increased in SDIA patients compared to results in non-SDIA patients in the age group over 60 years. 3. Of ventilatory parameters, the values of % FVC, FEV(1.0%), % MMF and % V(25) were significantly lower in SDIA patients over the age of 60 compared with non-SDIA subjects of the same age group. These results show that in SDIA patients the proportion of BAL lymphocytes decreases and the proportion of BAL neutrophils increases with aging, and that ventilatory function in SDIA patients also decreases with aging compared to non-SDIA patients.
Abstract Alternative 年齢により3群(20-39才,40-59才,60才以上)に分類された気管支喘息86例(ステロイド依存性重症難治性喘息:SDIA;43例,非SDIA;43例)を対象に,気管支肺胞洗浄液(BALF)中の細胞成分および換気機能よりSDIAにおける気 道反応の特徴を検討した。1.血清コーチゾ-ル値は,SDIA症例において, 非SDIA症例に比べいずれの年齢層においても有意の低値を示した。2.BALF中リンパ球頻度は,40-59才および60才以上のSDIA症例において,同年齢の非SDIA症例に比べ有意の低値を示した。一方,BALF中好中球頻度は,60才以上のSDIA症例で,同年齢層の非SDIA症例に比べ有意に高い値を示 した。また,BALF中好酸球頻度は,いずれの年齢層においても,SDIAと非SDIA症例の間に有意の差は見られなかった。3.換気機能では,% FVC, FEV1.0%,% MMF, % V(25)などの換気パラメーターは,60才以上の SDIA症例において,同年齢層の非SDIA症例に比べて有意の低値を示した。 これらの結果は,40-59才あるいは60才以上のSDIA症例では,非SDIA症例に比べ,BALF中リンパ球頻度の低下,好中球頻度の増加,換気パラメーター値の低下などがより高度に見られることを示している。
Keywords bronchial asthma (気管支喘息) bronchoalveolar cells (気管支肺胞洗浄液中の細胞) ventilatory function (換気機能) glucocorticoids (グルココーチコイド) serum cortiosol levels (血清コーチゾール値)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 40
End Page 47
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307402
JaLCDOI 10.18926/11625
Title Alternative Spa therapy for chronic respiratory diseases - in subjects admitted in 1989. -
FullText URL 061_007_015.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Kawauchi, Kazuhisa| Mifune, Takashi| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract 1989年1月より12月までの1年間に当院へ入院した慢性呼吸器疾患患者85例(延べ90例)を対象に,その背景因子,臨床的特徴,および温泉療法の臨床効果について検討を加えた。(1)対象85例のうちわけは,気管支喘息65例,肺気腫4例,肺結核症4例,アレルギー性肉芽腫性血管炎3例,閉塞性細気管支炎3例,気管支拡張症2例,慢性気管支炎2例,過敏性肺臓炎2例であり,昨年度と異なり肺結核がやや多かったことが特徴的であった。(2)これら85症例のうち,温泉療法を受けた症例は63例(74.1%)であった。(3)温泉療 法を受けた症例の地域分布では,鳥取県からの入院症例51例では32例(62.7%)であり,同様に岡山県からの入院症例20例では19例(95.0%),その他の県からの入院症例14例で12例(85.7%)であった。4.温泉療法の臨床効果は,気管支喘息では51例中著効14例,有効27例,やや有効8例,無効2例であり,明らかな有効例は41例(80.3%)であった。
Abstract Alternative Backgrounds and immunological characteristics were studied in patients with chronic respiratory diseases admitted at Misasa Branch Hospital in 1989. At the same time, clinical effects of spa therapy were evaluated for these patients. 1. Eighty five patients with chronic respratory diseases comprised 65 patients with bronchial asthma, 4 with pulmonary emphysema, 4 with lung tuberculosis, 3 with allergic granulomatous angitis, 3 with obstructive bronchiolitis, 2 with bronchiectasia, 2 with chronic bronchitis and 2 with hypersensitivity pneumonitis. 2. Sixty three patients (74.1%) out of the 85 cases had spa therapy. 3. Out of 51 patients coming from Tottori prefecture, 32 cases (62.7%) received spa therapy. On the other hand, spa therapy was carried out for 19 cases (95.0%) out of the 20 cases from Okayama prefecture, and for 12 cases (85.7%) out of the 14 cases from the other prefectures (long distant areas). 4. Many cases with bronchial asthma showed low serum levels of IgE (lower than 200 IU/ml), and frequency of positive skin reactions to various allergens was low in the patients with bronchial asthma. Serum cortisol levels were very low in patients with steroid-dependent asthma. 5. Spa therapy was effective in 41 cases (80.3%) out of the 51 patients with bronchial asthma. Spa therapy also effective for patients with obstructive bronchiolitis, and allergic granulomatous angitis.
Keywords 気管支喘息 (Bronchial asthma) 閉塞性細気管支炎 (Obstructive bronchiolitis) 慢性気管支炎 (Chronic bronchitis) 血清コーチゾール値 (Serum cortisol level) 温泉療法 (Spa therapy)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 7
End Page 15
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313875
Author Wickstrum, Yuuka|
Published Date 2015-12-30
Publication Title Bulletin of Higher Education Okayama University
Volume volume11
Content Type Departmental Bulletin Paper
JaLCDOI 10.18926/fest/11623
Title Alternative Rain-water Retention of a Small-scale Upland Field in a Rainy Year and a Droughty Year
FullText URL 001_143_149.pdf
Author Yomota, Atsushi|
Abstract From the standpoint of water resources development and environmental preservation, rain water retentivity of agricultural and forest lands are evaluated. Measurement of rainfall and runoff has been carried out at the reclaimed upland field of 4.55 ha since 1981. In this article, water retention characteristics of this study basin is compared in a rainy year of 1993 and a droughty year of 1994. In cases of rainfall less than 20mm, most of the rain water infiltrates into the soil layer. On the other hand, about 75% of a heavy rain, such as 300 mm in 1993, runs off the soil surface. Within the infiltrating rain water, the ratio of water which is kept by capillary action and can be used by crops is estimated to be less than 40% in months of rainfall more than 150 mm, but in months of rainfall less than 50 mm, it is estimated that more than 80% of rainfall can be used by crops. The ratio of monthly rainfall which contributes to base flow recharge is 0 to 12% regardless of rainfall amount.
Keywords upland field monthly rainfall rain water retention effective rainfall base flow recharge
Publication Title 岡山大学環境理工学部研究報告
Published Date 1996-03
Volume volume1
Issue issue1
Start Page 143
End Page 149
ISSN 1341-9099
language 日本語
File Version publisher
NAID 120002313677
JaLCDOI 10.18926/fest/11621
Title Alternative On the Role of Subjunctive Mood in Hardy's "Had You Wept": In Comparison with a Poem of Bécquer
FullText URL 002_163_167.pdf
Author Kanzaki, Ken-ichi|
Publication Title 岡山大学環境理工学部研究報告
Published Date 1997-01-10
Volume volume2
Issue issue1
Start Page 163
End Page 167
ISSN 1341-9099
language 日本語
File Version publisher
NAID 120002314014
Author Kobayashi, Takayuki|
Published Date 2007-03-31
Publication Title 文化共生学研究
Volume volume6
Issue issue1
Content Type Departmental Bulletin Paper
JaLCDOI 10.18926/12840
JaLCDOI 10.18926/fest/11620
Title Alternative Vonnegut's Brain Computer Laying stress on Galápagos and Hocus Pocus
FullText URL 002_145_161.pdf
Author Morokawa, Shigetake|
Abstract As Kurt Vonnegut (1922--) has written his novels to give warnings about the growing danger of society, in the case of valuation, it is very important to understand what happened in his time and how his works resulted from a historic background. In the late of 1970's and 80's, society underwent a few big changes, for example, signs of communism collapse on a line of the Soviet Union's perestoroika, Japanese rapid economic growth, the unbalanced world economy by the heavy fall in stock prices in America and, in the field of science, the progress of computer technology in the use of a semiconductor instead of a vacuum tube. The mentioned above data were input into Vonnegut's Brain Computer. As a result, Galápagos was publishied in 1985, Hocus Pocus in 1990. In this paper, I analyzes Vonnegut's works from such a point of view, laying stress on Galápagos and Hocus Pocus.
Publication Title 岡山大学環境理工学部研究報告
Published Date 1997-01-10
Volume volume2
Issue issue1
Start Page 145
End Page 161
ISSN 1341-9099
language 日本語
File Version publisher
NAID 120002313892
JaLCDOI 10.18926/15149
Title Alternative A case report of severe allergic reactionsinduced by black fly bites
FullText URL 065_017_021.pdf
Author Kitani, Hikaru| Takata, Ichiro| Yokota, Satoshi| Kajimoto, Kazuhiro| Mitsunobu, Fumihiro| Mifune, Takashi| Tanizaki, Yoshiro|
Abstract 多数のブユに刺されたのを契機に重症反応を呈するようになった29歳男性例について,アレルギー学的検討を行った。血清IgE値が高値(4591U/ml)であったが,免疫グロブリン,抗核抗体,血清補体価,CD4,CD8陽性リンパ球出現頻度などいずれも正常であり,またハウスダスト,カンジダその他16種類の吸入性抗原,ミツバチ,スズメバチ,アシナガバチ,ゴキブリ,ヤブカ,ユスリカなどの昆虫抗原に対する特異的IgE抗体はいずれも陰性であった。一方ニッポンヤマブユ抗原による好塩基球からのヒスタミン遊離は陰性であったが,皮膚反応,IgE抗体は陽性を示したことから,本症例における重症化因子としてIgE系反応の関与が示唆された。なおEBウイルス抗体価の検討では,EBV-EADR抗体はすべて陰性,EBNA-EIA抗体はIgG抗体のみ陽性であり,EBウイルスの既感染状態と判断されたが,病因との関連は明らかではなかった。
Abstract Alternative Allergic examinations were studied on the 29 years old male case, who suffered from severe systemic reactions by black fly bites, after the episode of much black fly bites in 1987. The level of serum IgE was high in the case, and both skin reaction and specitic IgE antibodies to whole body extract of black fly (Simulium nacojapi) were positive. The results obtained here suggest that IgE-mediated allergic reaction would play an important role in the severe systemic reactions induced by black fly bites.
Keywords 昆虫アレルギー (lnsect allergy) ブユ (Black fly) IgE系反応 (lgE-mediated reaction)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 17
End Page 21
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307240
JaLCDOI 10.18926/fest/11618
Title Alternative Transport Policy in United Kingdom -Concept and Practice for Better Transport Environment
FullText URL 001_091_113.pdf
Author Inouye, Hiroshi|
Abstract The movement of transport policy in United Kingdom and its problems are surveyed in this paper. First, the general trend in transport, road program, and technologies to improve road safety and environment are introduced. Then, concepts to decrease traffic congestion are outlined, followed parking control strategies. Recent issues such as road pricing scheme in London, M25 widening plan, also deregulation and privatisation of transport and their problems are examined.
Publication Title 岡山大学環境理工学部研究報告
Published Date 1996-03
Volume volume1
Issue issue1
Start Page 91
End Page 113
ISSN 1341-9099
language 日本語
File Version publisher
NAID 120002314020