JaLCDOI 10.18926/AMO/55204
FullText URL 71_3_219.pdf
Author Takakura, Hiroaki| Domae, Shohei| Ono, Toshiro| Sasaki, Akira|
Abstract  Anticancer drugs induce cell-cycle arrest and apoptosis not only in tumor cells, but also in immune cells. However, many preclinical and clinical findings show that some chemotherapeutic agents can improve the antitumor efficacy of immunotherapy. We immunohistochemically analyzed the degree of immune cell infiltration and the relevance of programmed cell death 1 ligand-1 (PD-L1) expression in surgically resected oral squamous cell carcinoma (OSCC) specimens from patients who had undergone pretreatment with certain chemotherapies and other patients without pretreatment. We divided the patients into the group of neoadjuvant chemotherapy (NAC) patients (n=8) and the nNAC (without NAC) patient group (n=10). We observed that NAC induced infiltrations of CD4, CD8 T cells and CD56 NK cells into the tumor microenvironment. Decreased numbers of Tregs and PD-1-positive cells were observed in the NAC group. No significant difference was observed in the degree of immune-cell infiltration between the patient groups except for CD56 NK cells in the stroma and PD-1 cells in cancer nests. Eighty percent of the nNAC specimens showed intermediate-to-strong PD-L1 protein expression, whereas 75% of the NAC specimens showed down-regulation of the PD-L1 protein, indicating the effectiveness of the chemotherapeutic treatment before surgery.
Keywords oral squamous cell carcinoma programmed cell death 1 ligand-1 tumor microenvironment neoadjuvant chemotherapy immunohistochemistry
Amo Type Original Article
Published Date 2017-06
Publication Title Acta Medica Okayama
Volume volume71
Issue issue3
Publisher Okayama University Medical School
Start Page 219
End Page 226
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2017 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 28655941
JaLCDOI 10.18926/AMO/54506
FullText URL 70_4_291.pdf
Author Yoshioka, Norie| Shimo, Tsuyoshi| Ibaragi, Soichiro| Sasaki, Akira|
Abstract Temporomandibular joint (TMJ) dislocation can occur during daily activities and negatively affect a patientʼs quality of life. Although both nonsurgical and surgical techniques have been used to treat recurrent TMJ dislocation, the former is not always successful and the latter, although having a high success rate, is invasive and requires hospitalization. Recently, autologous blood injection has been used to treat recurrent TMJ dislocation. However, this technique is not yet widely used in clinical practice. We designed this study to obtain further information as to efficacy, safety and stability of autologous blood injection for recurrent TMJ dislocation.
Keywords autologous blood injection recurrent temporomandibular joint dislocation
Amo Type Clinical Study Protocols
Published Date 2016-08
Publication Title Acta Medica Okayama
Volume volume70
Issue issue4
Publisher Okayama University Medical School
Start Page 291
End Page 294
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2016 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 27549675
Web of Sience KeyUT 000384748600010
Author Yamanaka, Reiko| Soga, Yoshihiko| Nawachi, Kumiko| Yanagi, Yoshinobu| Kodama, Naoki| Nakata, Takashi| Miura, Rumi| Hagawa, Misao| Takeuchi, Tetsuo| Yamane, Mieko| Morita, Manabu| Takashiba, Shogo| Asami, Jun-ichi| Minagi, Shogo| Yoshiyama, Masahiro| Shimono, Tsutomu| Kuboki, Takuo| Sasaki, Akira| Morita, Kiyoshi|
Published Date 2009-06
Publication Title 岡山歯学会雑誌
Volume volume28
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/49257
FullText URL 67_1_55.pdf
Author Shimo, Tsuyoshi| Nishiyama, Akiyoshi| Jinno, Tokiari| Sasaki, Akira|
Abstract In this article, we report the successful surgical treatment of a patient, 34 years of age, who had a severe gummy smile and a class II malocclusion. The patient had an 11-mm gingival exposure during full smile and a convex profile. A LeFort I osteotomy combined with a horseshoe osteotomy was used for the superior repositioning of the maxilla;then, an intraoral vertical ramus osteotomy (IVRO) and genioplasty were performed for mandibular advancement. The maxilla was acceptably impacted 8mm at the first incisor and 5mm at the first molar. Both the occlusion and facial appearance were significantly improved by this surgical-orthodontic treatment. Our results suggest that the combination of a horseshoe osteotomy with a LeFort I osteotomy is a useful technique for reliable superior repositioning of the maxilla.
Keywords LeFort I osteotomy horseshoe osteotomy gummy smile
Amo Type Case Report
Published Date 2013-02
Publication Title Acta Medica Okayama
Volume volume67
Issue issue1
Publisher Okayama University Medical School
Start Page 55
End Page 60
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23439509
Web of Sience KeyUT 000316829900007
Author Fujioka, Shinsuke| Nishimura, Hiroaki| Nishihara, Katsunobu| Sasaki, Akira| Sunahara, Atsushi| Okuno, Tomoharu| Ueda, Nobuyoshi| Ando, Tsuyoshi| Tao, Yezheng| Shimada, Yoshinori| Hashimoto, Kazuhisa| Yamaura, Michiteru| Shigemori, Keisuke| Nakai, Mitsuo| Nagai, Keiji| Norimatsu, Takayoshi| Nishikawa, Takeshi| Miyanaga, Noriaki| Izawa, Yasukazu| Mima, Kunioki|
Published Date 2005-11
Publication Title Physical Review Letters
Volume volume95
Issue issue23
Content Type Journal Article
Author Matsubaya, Osamu| Sakai, Hitoshi| Ueda, Akira| Tsutsumi, Makoto| Kusakabe, Minoru| Sasaki, Akira|
Published Date 1978-03-25
Publication Title 岡山大学温泉研究所報告
Volume volume47
Content Type Departmental Bulletin Paper
Author Matsubaya, Osamu| Sakai, Hitoshi| Kusakabe, Minoru| Sasaki, Akira|
Published Date 1980-03-25
Publication Title 岡山大学温泉研究所報告
Volume volume50
Content Type Departmental Bulletin Paper
Author 佐々木 朗|
Published Date 1990-10-31
Publication Title
Content Type Thesis or Dissertation