このエントリーをはてなブックマークに追加
ID 53016
FullText URL
Author
Nishiyama, Keiko
Iwamoto, Takayuki
Ishihara, Setsuko
Kawai, Hiroshi
Kawasaki, Kensuke
Ishibe, Youichi
Ogasawara, Yutaka
Komoike, Yoshifumi
Abstract
Background: Lifestyle factors, including food and nutrition, physical activity, body composition and reproductive factors, and single nucleotide polymorphisms (SNPs) are associated with breast cancer risk, but few studies of these factors have been performed in the Japanese population. Thus, the goals of this study were to validate the association between reported SNPs and breast cancer risk in the Japanese population and to evaluate the effects of SNP genotypes and lifestyle factors on breast cancer risk. Methods: A case-control study in 472 patients and 464 controls was conducted from December 2010 to November 2011. Lifestyle was examined using a self-administered questionnaire. We analyzed 16 breast cancer-associated SNPs based on previous GWAS or candidate-gene association studies. Age or multivariate-adjusted odds ratios (OR) and 95% confidence intervals (95% CI) were estimated from logistic regression analyses. Results: High BMI and current or former smoking were significantly associated with an increased breast cancer risk, while intake of meat, mushrooms, yellow and green vegetables, coffee, and green tea, current leisure-time exercise, and education were significantly associated with a decreased risk. Three SNPs were significantly associated with a breast cancer risk in multivariate analysis: rs2046210 (per allele OR = 1.37 [95% CI: 1.11-1.70]), rs3757318 (OR = 1.33[1.05-1.69]), and rs3803662 (OR = 1.28 [1.07-1.55]). In 2046210 risk allele carriers, leisure-time exercise was associated with a significantly decreased risk for breast cancer, whereas current smoking and high BMI were associated with a significantly decreased risk in non-risk allele carriers. Conclusion: In Japanese women, rs2046210 and 3757318 located near the ESR1 gene are associated with a risk of breast cancer, as in other Asian women. However, our findings suggest that exercise can decrease this risk in allele carriers.
Keywords
Japanese women
Asian
Breast cancer
Lifestyle
Leisure-time exercise
Parity
Single nucleotide polymorphisms
rs2046210
rs3757318
ESR1
Published Date
2013-12-01
Publication Title
BMC Cancer
Volume
volume13
Publisher
BioMed Central Ltd.
ISSN
1471-2407
Content Type
Journal Article
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/52972
language
英語
Copyright Holders
© 2013 Mizoo et al.; licensee BioMed Central Ltd.
File Version
publisher
Refereed
True
DOI
Web of Sience KeyUT