岡山大学農学部 Acta Medica Okayama 0474-0254 85 1 1996 哺乳類の分子遺伝学 89 98 EN Tetsuo Kunieda Recent advances in molecular genetics of mammals,including construction of genetic linkage maps, identification of mutations responsible for inheritable diseases, mapping of quantitative trait loci,and findings about sex determination are reviewed in the present paper. Information about genomes of humans,laboratory animals and domestic animals has been rapidly accumulated in the last decade. Establishment of polymorphic linkage markers and construction of chromosomal linkage maps of mammalian species enable us to identify the genes responsible for particular genetic traits. Various mutations have been found in genes responsible for human inheritable diseases. We have constructed genetic linkage maps for rats and identified a mutation responsible for mucopoly saccharidosis in rats. Mapping of loci affecting the quantitative traits of domestic animals, including growth rate, litter size, and milk production, as well as identification of the genes responsible for inheritable diseases of domestic animals, are also being carried out.Recently, the testis-determining gene on the Y chromosome, which determine the sex of mammals by defferentiating the testis in the embryos, have been identified in humans and mice. Functions of the sex-determining gene in sexual differentiation of the mammalian embryos have been intensively analyzed. We have found a sexual difference in the growth rate of mouse preimplantation embryos. An application of the recent findings in the molecular genetics of mammals will contribute to animal science and agricultural science. No potential conflict of interest relevant to this article was reported.

岡山実験動物研究会 Acta Medica Okayama 32 2016 会長あいさつ 1 1 EN Tetsuo Kunieda No potential conflict of interest relevant to this article was reported.

岡山実験動物研究会 Acta Medica Okayama 33 2017 会長あいさつ 1 1 EN Tetsuo Kunieda Graduate School of Environmental and Life Science, Okayama University No potential conflict of interest relevant to this article was reported.

岡山実験動物研究会 Acta Medica Okayama 34 2018 会長あいさつ 1 1 EN Tetsuo Kunieda Graduate School of Natural Science and Technology, Okayama University No potential conflict of interest relevant to this article was reported.