このエントリーをはてなブックマークに追加
ID 40133
JaLCDOI
FullText URL
Author
Masumoto, Akio
Takamoto, Norio
Akahori, Yoichiro
Abstract
It has been reported that prolactin (PRL) is cleaved to 14 or 16 kDa fragments by cathepsin D in vitro and in vivo, and that such fragments exhibit antiangiogenic and proapoptotic properties. The aim of this study was to investigate the relationship between pregnancy induced hypertension (PIH) and the placental expression of antiangiogenic PRL fragments and cathepsin D. Placental expression of PRL fragments and cathepsin D was evaluated by Western blot analysis in a group of 9 pregnant women consisting of 5 normal pregnancies and 4 severe PIH cases. Antiangiogenic PRL fragments were detected in 4 placental samples from all PIH cases but not detected in those from normal pregnancies (p0.05). The expression of cathepsin D in PIH placentas was significantly lower than that in those without PIH (p0.05), while the placental expression of procathepsin D was significantly greater in PIH cases than in the normal pregnancies (p0.05). These data suggest that antiangiogenic PRL fragments in the placenta may be present only in PIH cases, and that PRL fragments in the placenta might be implicated in the pathophysiology of PIH.
Keywords
pregnancy induced hypertension
preeclampsia
prolactin
prolactin fragment
cathepsin-D
Amo Type
Original Article
Published Date
2010-08
Publication Title
Acta Medica Okayama
Volume
volume64
Issue
issue4
Publisher
Okayama University Medical School
Start Page
249
End Page
255
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT