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Sada, Ken-ei Department of Nephrology, Rheumatology, Endocrinology and Metabolism , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Harigai, Masayoshi Department of Rheumatology, Graduate School of Medical and Dental Sciences , Tokyo Medical and Dental University
Amano, Koichi Department of Rheumatology and Clinical Immunology , Saitama Medical Center, Saitama Medical University
Atsumi, Tatsuya Division of Rheumatology, Endocrinology and Nephrology at the Graduate School of Medicine , Hokkaido University
Fujimoto, Shouichi Department of Hemovascular Medicine and Artificial Organs, Faculty of Medicine , Miyazaki University
Yuzawa, Yukio Department of Nephrology , Fujita Health University School of Medicine
Takasaki, Yoshinari Department of Internal Medicine and Rheumatology , Juntendo University School of Medicine
Banno, Shogo Division of Rheumatology and Nephrology, Department of Internal Medicine , Aichi Medical University School of Medicine
Sugihara, Takahiko Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
Kobayashi, Masaki Department of Nephrology , Tokyo Medical University Ibaraki Medical Center
Usui, Joichi Department of Nephrology, Faculty of Medicine , University of Tsukuba
Yamagata, Kunihiro Department of Nephrology, Faculty of Medicine , University of Tsukuba
Homma, Sakae Department of Respiratory Medicine , Toho University Omori Medical Center
Dobashi, Hiroaki Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine , Kagawa University
Tsuboi, Naotake Department of Nephrology, Internal Medicine , Nagoya University Graduate School of Medicine
Ishizu, Akihiro Faculty of Health Sciences , Hokkaido University
Sugiyama, Hitoshi Department of Chronic Kidney Disease and Peritoneal Dialysis , Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Okada, Yasunori Department of Pathology , Keio University School of Medicine
Arimura, Yoshihiro Nephrology and Rheumatology, First Department of Internal Medicine , Kyorin University School of Medicine
Matsuo, Seiichi Department of Nephrology, Internal Medicine , Nagoya University Graduate School of Medicine
Makino, Hirofumi Okayama University Hospital
Abstract
OBJECTIVE: To compare disease severity classification systems for six-month outcome prediction in patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). METHODS: Patients with newly diagnosed AAV from 53 tertiary institutions were enrolled. Six-month remission, overall survival, and end-stage renal disease (ESRD)-free survival were evaluated. RESULTS: According to the European Vasculitis Study Group (EUVAS)-defined disease severity, the 321 enrolled patients were classified as follows: 14, localized; 71, early systemic; 170, generalized; and 66, severe disease. According to the rapidly progressive glomerulonephritis (RPGN) clinical grading system, the patients were divided as follows: 60, grade I; 178, grade II; 66, grade III; and 12, grade IV. According to the Five-Factor Score (FFS) 2009, 103, 109, and 109 patients had ≤1, 2, and ≥3 points, respectively. No significant difference in remission rates was found in any severity classification. The overall and ESRD-free survival rates significantly differed between grades I/II, III, and IV, regardless of renal involvement. Severe disease was a good predictor of six-month overall and ESRD-free survival. The FFS 2009 was useful to predict six-month ESRD-free survival but not overall survival. CONCLUSIONS: The RPGN grading system was more useful to predict six-month overall and ESRD-free survival than the EUVAS-defined severity or FFS 2009.
Keywords
Antineutrophil cytoplasmic antibody-associated vasculitis
Eosinophilic granulomatosis with polyangiitis
Granulomatosis with polyangiitis
Inception cohort
Microscopic polyangiitis
Note
This is an Accepted Manuscript of an article published by Taylor & Francis Group
Published Date
2016-03-11
Publication Title
Modern Rheumatology
Volume
volume26
Issue
issue5
Publisher
Taylor & Francis
Start Page
730
End Page
737
ISSN
1439-7595
NCID
AA1157187X
Content Type
Journal Article
language
英語
OAI-PMH Set
岡山大学
Copyright Holders
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
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Related Url
https://doi.org/10.3109/14397595.2016.1140274