Title Alternative Inhibitory effects of caffeine on allergic rhinitis symptoms in mice
FullText URL poalas_033_018_021.pdf
Author Tsujimoto, Madoka| Saiki, Akiko| Suzuki, Manami| Shiraga, Toshiyuki| Sugimoto, Yukio| Hayashi, Yasushi|
Abstract We examined the effects of caffeine treatment on ovalbumin- and histamine-induced rhinitis mouse models and on corticosterone and catecholamine levels in mouse plasma. Treatment with caffeine decreased sneezing and nasal rubbing in both models, but direct nasal administration had no effect. Plasma levels of corticosterone and catecholamine, which have known anti-allergy effects, were increased by caffeine treatment. The increases in corticosterone and catecholamine may be associated with the suppression of rhinitis symptoms.
Publication Title Proceedings of Okayama Association for Laboratory Animal Science
Published Date 2017-04
Volume volume33
Start Page 18
End Page 21
language 日本語
File Version publisher
Author Ishimoto, Hidekazu| Shibata, Mari| Myojin, Yuki| Ito, Hideyuki| Sugimoto, Yukio| Tai, Akihiro| Hatano, Tsutomu|
Published Date 2011-10-01
Publication Title Bioorganic & Medicinal Chemistry Letters
Volume volume21
Issue issue19
Content Type Journal Article
JaLCDOI 10.18926/AMO/31623
FullText URL fulltext.pdf
Author Sugimoto, Yukio| Iba, Yoshionori| Ishizawa, Keisuke| Suzuki, Genzo| Kamei, Chiaki|
Abstract <p><p>The effects of levocabastine, a novel histamine H1-receptor antagonist, on lipid mediator release induced by antigen-antibody reaction from actively sensitized guinea pig lung fragments were studied. Levocabastine dose-dependently inhibited the release of leukotriene C4 from guinea pig lung fragments induced by antigen. A significant effect was observed with levocabastine at a concentration of 10(-4) M. On the other hand, levocabastine produced no effect on the release of leukotriene E4 or thromoboxane B2. From these findings, it was concluded that levocabastine may be useful for relieving the nasal obstruction in allergic rhinitis caused by inhibition of leukotriene C4 release.</p></p>
Keywords levocabastine guinea pig lung fragment lipid mediator
Amo Type Brief Note
Published Date 1999-12
Publication Title Acta Medica Okayama
Volume volume53
Issue issue6
Publisher Okayama University Medical School
Start Page 271
End Page 274
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 10631382
Web of Science KeyUT 000084414300005
Author Sugimoto, Yukio|
Published Date 2003-09
Publication Title 岡山実験動物研究会報
Volume volume20
Content Type Journal Article
Author 杉本 幸雄|
Published Date 1998-09-30
Publication Title
Content Type Thesis or Dissertation