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ID 31596
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Author
Miyamoto, Osamu
Itano, Toshifumi
Fujisawa, Mutsuo
Tokuda, Masaaki
Nagao, Seigo
Hatase, Osamu
Abstract

Basic fibroblast growth factor (bFGF) and nerve growth factor (NGF) were administered into the rat brain following unilateral fimbria-fornix transection. Both bFGF and NGF stimulated the sprouting of acetylcholinesterase (AChE) positive fibers in the hippocampus on the lesioned side. Furthermore, a small number of AChE-positive fibers were regenerated even when only the vehicle was administered. Rats treated with NGF as well as control group had only thin fibers, whereas those treated with bFGF had not only thin fibers but also thick fibers. These results indicate that intrinsic NGF is released and acts on damaged neurons directly, while bFGF acts them on directly and/or indirectly after brain injury.

Keywords
bFGF
NGF
regeneration
acetylcholinesterase positive fibers
sprouting
Amo Type
Article
Published Date
1993-06
Publication Title
Acta Medica Okayama
Volume
volume47
Issue
issue3
Publisher
Okayama University Medical School
Start Page
139
End Page
144
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Science KeyUT