Author Terami, Takahiro| Wada, Jun| Inoue, Kentaro| Nakatsuka, Atsuko| Ogawa, Daisuke| Teshigawara, Sanae| Murakami, Kazutoshi| Katayama, Akihiro| Eguchi, Jun| Makino, Hirofumi|
Published Date 2013-10-22
Publication Title International Journal of Nephrology and Renovascular Disease
Volume volume6
Content Type Journal Article
Author Tsuji, Kenji| Kitamura, Shinji| Makino, Hirofumi|
Published Date 2014-04-25
Publication Title Biochemical and Biophysical Research Communications
Volume volume447
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/53117
FullText URL 69_1_1.pdf
Author Watatani, Hiroyuki| Yamasaki, Hiroko| Maeshima, Yohei| Nasu, Tatsuyo| Hinamoto, Norikazu| Ujike, Haruyo| Sugiyama, Hitoshi| Sakai, Yoshiki| Tanabe, Katsuyuki| Makino, Hirofumi|
Abstract Diabetic nephropathy is the most common pathological disorder predisposing patients to end-stage renal disease. Considering the increasing prevalence of type 2 diabetes mellitus worldwide, novel therapeutic approaches are urgently needed. ONO-1301 is a novel sustained-release prostacyclin analog that inhibits thromboxane A2 synthase. Here we examined the therapeutic effects of the intermittent administration of slow-release ONO-1301 (SR-ONO) on diabetic nephropathy in obese type 2 diabetes mice, as well as its direct effects on mesangial cells. The subcutaneous injection of SR-ONO (3mg/kg) every 3 wks did not affect the obesity or hyperglycemia in the db/db obese mice used as a model of type 2 diabetes, but it significantly ameliorated their albuminuria, glomerular hypertrophy, glomerular accumulation of type IV collagen, and monocyte/macrophage infiltration, and also the increase of TGF-β1, α-smooth muscle actin (α-SMA) and MCP-1 compared to vehicle treatment. In cultured mouse mesangial cells, ONO-1301 concentration-dependently suppressed the increases in TGF-β, type IV collagen, α-SMA, MCP-1 and fibronectin induced by high ambient glucose, at least partly through prostacyclin (PGI2) receptor-mediated signaling. Taken together, these results suggest the potential therapeutic efficacy of the intermittent administration of SR-ONO against type 2 diabetic nephropathy, possibly through protective effects on mesangial cells.
Keywords prostacyclin ONO-1301 diabetic nephropathy TGF-β1 diabetes mellitus
Amo Type Original Article
Published Date 2015-02
Publication Title Acta Medica Okayama
Volume volume69
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 15
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2015 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25703166
Web of Science KeyUT 000349740300001
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/53128
Title Alternative Advances in Diabetology, The 49th Annual Post Graduate Course
FullText URL 127_167.pdf
Author Makino, Hirofumi|
Publication Title 岡山医学会雑誌
Published Date 2015-08-03
Volume volume127
Issue issue2
Start Page 167
End Page 168
ISSN 0030-1558
Related Url isVersionOf https://doi.org/10.4044/joma.127.167
language 日本語
Copyright Holders Copyright (c) 2015 岡山医学会
File Version publisher
DOI 10.4044/joma.127.167
NAID 130005096244
Author Kitamura, Shinji| Sakurai, Hiroyuki| Makino, Hirofumi|
Published Date 2015-03
Publication Title Stem cells
Volume volume33
Issue issue3
Content Type Journal Article
Author Katayama, Akihiro| Nakatsuka, Atsuko| Eguchi, Jun| Murakami, Kazutoshi| Teshigawara, Sanae| Kanzaki, Motoko| Nunoue, Tomokazu| Hida, Kazuyuki| Wada, Nozomu| Yasunaka, Tetsuya| Ikeda, Fusao| Takaki, Akinobu| Yamamoto, Kazuhide| Kiyonari, Hiroshi| Makino, Hirofumi| Wada, Jun|
Published Date 2015
Publication Title Scientific reports
Volume volume5
Content Type Journal Article
Author Ogawa, Daisuke| Eguchi, Jun| Wada, Jun| Terami, Naoto| Hatanaka, Takashi| Tachibana, Hiromi| Nakatsuka, Atsuko| Sato Horiguchi, Chikage| Nishii, Naoko| Makino, Hirofumi|
Published Date 2014-01-22
Publication Title PLOS ONE
Volume volume9
Issue issue1
Content Type Journal Article
Author Watanabe, Mayu| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Higuchi, Chigusa| Katayama, Akihiro| Teshigawara, Sanae| Eguchi, Jun| Ogawa, Daisuke| Watanabe, Eijiro| Wada, Jun| Makino, Hirofumi|
Published Date 2014-05-25
Publication Title PLOS ONE
Volume volume9
Issue issue3
Content Type Journal Article
Title Alternative Clinical Research Core Center and Okayama University
FullText URL 129_45.pdf
Author Makino, Hirofumi|
Keywords オール岡山大学 臨床研究中核病院 橋渡し研究加速ネットワークプログラム事業
Publication Title Journal of Okayama Medical Association
Published Date 2017-04-03
Volume volume129
Issue issue1
Start Page 45
End Page 49
ISSN 0030-1558
language 日本語
Copyright Holders Copyright (c) 2017 岡山医学会
File Version publisher
DOI 10.4044/joma.129.45
NAID 130005632070
Title Alternative The perception of chronic kidney disease in a general population in Okayama, Japan : 2015
FullText URL 129_101.pdf
Author Uchida, Haruhito A.| Sugiyama, Hitoshi| Miyazaki, Masashi| Wada, Jun| Shikata, Kenichi| Kashihara, Naoki| Makino, Hirofumi|
Abstract  Public education programs about chronic kidney disease (CKD) have been performed in Okayama, Japan for the past 10 years. The present study investigated the perception of CKD in a general population in Okayama. In October and November 2015, a questionnaire survey was distributed by 12 medical centers in five medical districts in Okayama prefecture. A total of 7,022 respondents who underwent their physical checkup at these centers answered the questionnaire. In response to a questionnaire item asking about the respondent's familiarity with the term "CKD," only 4% of the respondents answered "know it well" and 10% answered "unfamiliar." In contrast, in response to a questionnaire item asking about the respondent's familiarity with "chronic kidney disease," 27% answered "know it well" and 38% answered "unfamiliar." The leading avenue by which the respondents learned about CKD/chronic kidney disease was television, followed by newspapers, magazines, and a family doctor or nurse. The leading component which the respondents considered essential for the diagnosis of CKD/chronic kidney disease was proteinuria. A stratified analysis demonstrated a higher recognition of “CKD" or “chronic kidney disease" in the medical districts in northern Okayama prefecture compared to southern Okayama prefecture. These results indicated that the awareness of CKD in Okayama prefecture is still inadequate. Many people did not appear to realize that the term “CKD" represents "chronic kidney disease". Further continuous public education efforts are required to enlighten people about CKD/chronic kidney disease.
Keywords 慢性腎臓病 (chronic kidney disease) CKD 認知度 (perception) 岡山県 (Okayama) 医療圏別 (medical distinct)
Publication Title Journal of Okayama Medical Association
Published Date 2017-08-01
Volume volume129
Issue issue2
Start Page 101
End Page 105
ISSN 0030-1558
Related Url https://doi.org/10.4044/joma.129.101
language 日本語
Copyright Holders Copyright (c) 2017 岡山医学会
File Version publisher
DOI 10.4044/joma.129.101
NAID 130006039371
FullText URL Mod_Rheumatol_26_5_730.pdf
Author Sada, Ken-ei| Harigai, Masayoshi| Amano, Koichi| Atsumi, Tatsuya| Fujimoto, Shouichi| Yuzawa, Yukio| Takasaki, Yoshinari| Banno, Shogo| Sugihara, Takahiko| Kobayashi, Masaki| Usui, Joichi| Yamagata, Kunihiro| Homma, Sakae| Dobashi, Hiroaki| Tsuboi, Naotake| Ishizu, Akihiro| Sugiyama, Hitoshi| Okada, Yasunori| Arimura, Yoshihiro| Matsuo, Seiichi| Makino, Hirofumi|
Keywords Antineutrophil cytoplasmic antibody-associated vasculitis Eosinophilic granulomatosis with polyangiitis Granulomatosis with polyangiitis Inception cohort Microscopic polyangiitis
Note This is an Accepted Manuscript of an article published by Taylor & Francis Group|
Published Date 2016-03-11
Publication Title Modern Rheumatology
Volume volume26
Issue issue5
Publisher Taylor & Francis
Start Page 730
End Page 737
ISSN 1439-7595
NCID AA1157187X
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version author
PubMed ID 26873424
DOI 10.3109/14397595.2016.1140274
Web of Science KeyUT 000393120600018
Related Url https://doi.org/10.3109/14397595.2016.1140274