Author Nakatsuka, Atsuko| Wada, Jun| Makino, Hirofumi|
Published Date 2012-08-01
Publication Title 岡山医学会雑誌
Volume volume124
Issue issue2
Content Type Journal Article
JaLCDOI 10.18926/AMO/49041
FullText URL 66_6_449.pdf
Author Hanayama, Yoshihisa| Uchida, Haruhito Adam| Nakamura, Yoshio| Makino, Hirofumi|
Abstract Angiotensin receptor blockers (ARBs) are the first-line antihypertensive agents. In clinical practice, it is often difficult to achieve the recommended blood pressure level by ARBs in their ordinal dosages alone. This study examined the practical efficacy of a combination therapy of ARB with thiazide diuretics for lowering morning home blood pressure (MHBP) in comparison to high-dose ARB therapy in patients with morning hypertension administered an ordinal dosage of ARB. This study was performed in a prospective, randomized, open-labeled and blind-endpoint fashion. Patients were considered to have morning hypertension when their self-measured systolic MHBPs were 135mmHg or higher, irrespective of their diastolic MHBP and office blood pressures (OBPs). Forty-eight outpatients with morning hypertension receiving the ordinal dosage of ARB were given either losartan/hydrochlorothiazide (n=26) or high-dose ARB (n=22) in place of their previously prescribed ARB. No change in any medication was permitted during this period. Decreases of both systolic and diastolic MHBP after 3 months of treatment were significantly greater in the losartan/hydrochlorothiazide group than in the high-dose ARB group (p<0.05, respectively). The ratio of adverse events was somewhat high (23.1% in the losartan/hydrochlorothiazide group, 9.1% in the high-dose ARB group, respectively). However, there were no significant differences in any particular adverse event between groups. This study suggested losartan/hydrochlorothiazide might be superior to high-dose ARB for reducing morning home blood pressure.
Keywords losartan hydrochlorothiazide morning blood pressure angiotensin II hyperuricemia
Amo Type Original Article
Published Date 2012-12
Publication Title Acta Medica Okayama
Volume volume66
Issue issue6
Publisher Okayama University Medical School
Start Page 449
End Page 459
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2012 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23254579
Web of Sience KeyUT 000312966100004
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/49736
Author Takano, Mariko| Otsuka, Fumio| Matsumoto, Yoshinori| Inagaki, Kenichi| Takeda, Masaya| Nakamura, Eri| Tsukamoto, Naoko| Miyoshi, Tomoko| Sada, Ken-ei| Makino, Hirofumi|
Published Date 2012-01-02
Publication Title Molecular and Cellular Endocrinology
Volume volume348
Issue issue1
Content Type Journal Article
Author Takiue, Keiichi| Sugiyama, Hitoshi| Inoue, Tatsuyuki| Morinaga, Hiroshi| Kikumoto, Yoko| Kitagawa, Masashi| Kitamura, Shinji| Maeshima, Yohei| Wang, Dahong| Masuoka, Noriyoshi| Ogino, Keiki| Makino, Hirofumi|
Published Date 2012-05-25
Publication Title BMC Nephrology
Volume volume13
Issue issue14
Content Type Journal Article
Author Nakatsuka, Atsuko| Wada, Jun| Iseda, Izumi| Teshigawara, Sanae| Higashio, Kanji| Murakami, Kazutoshi| Kanzaki, Motoko| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Hida, Kazuyuki| Eguchi, Jun| Horiguchi, Chikage Sato| Ogawa, Daisuke| Matsuki, Yasushi| Hiramatsu, Ryuji| Yagita, Hideo| Kakuta, Shigeru| Iwakura, Yoichiro| Makino, Hirofumi|
Published Date 2012-11
Publication Title Diabetes
Volume volume61
Issue issue11
Content Type Journal Article
JaLCDOI 10.18926/AMO/50405
FullText URL 67_3_129.pdf
Author Nakatsuka, Atsuko| Wada, Jun| Makino, Hirofumi|
Abstract In recent years, many researchers have emphasized the importance of metabolic syndrome based on its increasing prevalence and its adverse prognosis due to associated chronic vascular complications. Upstream of a cluster of metabolic and vascular disorders is the accumulation of visceral adipose tissue, which plays a central role in the pathophysiology. In the accumulation of adipose tissues, cell cycle regulation is tightly linked to cellular processes such as proliferation, hypertrophy and apoptosis. In addition, various cell cycle abnormalities have also been observed in other tissues, such as kidneys and the cardiovascular system, and they are critically involved in the progression of disease. Here, we discuss cell cycle abnormalities in metabolic syndrome in various tissues. Furthermore, we describe the role of nuclear receptors in cell growth and survival, and glucose and lipid metabolism in the whole body. Therapeutic strategies for modulating various cell cycles in metabolic disorders by targeting nuclear receptors may overcome obesity and its chronic vascular complications in the future.
Keywords nuclear receptor cell cycle metabolic syndrome diabetic nephropathy
Amo Type Review
Published Date 2013-06
Publication Title Acta Medica Okayama
Volume volume67
Issue issue3
Publisher Okayama University Medical School
Start Page 129
End Page 134
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2013 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 23804135
Web of Sience KeyUT 000320747900001
Author Inoue, Junko| Wada, Jun| Teshigawara, Sanae| Hida, Kazuyuki| Nakatsuka, Atsuko| Takatori, Yuji| Kojo, Shoichirou| Akagi, Shigeru| Nakao, Kazushi| Miyatake, Nobuyuki| McDonald, John F.| Makino, Hirofumi|
Published Date 2012-12-03
Publication Title BMC Nephrology
Volume volume13
Content Type Journal Article
Author Nagase, Ryo| Kajitani, Nobuo| Shikata, Kenichi| Ogawa, Daisuke| Kodera, Ryo| Okada, Shinichi| Kido, Yuichi| Makino, Hirofumi|
Published Date 2012-10
Publication Title Clinical and Experimental Nephrology
Volume volume16
Issue issue5
Content Type Journal Article
Author Kurose, Yuko| Wada, Jun| Kanzaki, Motoko| Teshigawara, Sanae| Nakatsuka, Atsuko| Murakami, Kazutoshi| Inoue, Kentaro| Terami, Takahiro| Katayama, Akihiro| Watanabe, Mayu| Higuchi, Chigusa| Eguchi, Jun| Miyatake, Nobuyuki| Makino, Hirofumi|
Published Date 2013-01-22
Publication Title BMC Nephrology
Volume volume14
Content Type Journal Article
JaLCDOI 10.18926/AMO/52138
FullText URL 68_1_7.pdf
Author Horimoto, Naoya| Kitamura, Shinji| Tsuji, Kenji| Makino, Hirofumi|
Abstract Immunosuppressive agents are generally administered to treat kidney diseases. However, it is unclear whether renal stem/progenitor cells are directly affected by the immunosuppressive agents. We used normal rat kidney cells, ureteric bud cells and rat kidney stem/progenitor cells in this study. Mizoribine (MZR), cyclophosphamide (CPA) and cyclosporine (CyA) were added to the culture media of these cells. We evaluated the effects of these immunosuppressive agents on cell proliferation using an electrical cell-substrate impedance sensing system (ECIS) and their effects on the process of renal regeneration using the ischemia-reperfusion (I/R) injury rat model. The ECIS data showed that proliferation of each of the 3 types of cells was significantly suppressed by MZR. MZR treatment enhanced renal tubular injury in ischemia-reperfusion (I/R) injured rats, and significantly decreased levels of M-phase cells and Nestin-positive cells. These results suggested that MZR inhibits the cell cycle of renal stem/progenitor cells;thus, physicians should take note that MZR might affect not only inflammation but also renal regeneration.
Keywords cell biology immunosuppression stem cells
Amo Type Original Article
Published Date 2014-02
Publication Title Acta Medica Okayama
Volume volume68
Issue issue1
Publisher Okayama University Medical School
Start Page 7
End Page 15
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24553483
Web of Sience KeyUT 000331592800002
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/52247
JaLCDOI 10.18926/AMO/52143
FullText URL 68_1_43.pdf
Author Miyatake, Nobuyuki| Shikata, Kenichi| Makino, Hirofumi| Numata, Takeyuki|
Abstract The link between lifestyle modification and changes in both proteinuria and estimated glomerular filtration rates (eGFRs) was evaluated in Japanese subjects with proteinuria who were not taking medications. We used data from 51 men (35.8±10.0 years) and 74 women (38.0±11.0 years) with proteinuria at baseline and a 1-year follow up. eGFR was defined by a new equation developed specifically for Japanese subjects. Subjects were given advice for dietary and lifestyle improvement at the initial appointment. At the 1-year follow up, eGFR was increased in both sexes, but not at significant levels. (men:p=0.7709, women:p=0.2180). Proteinuria was also improved in many subjects. A decrease in proteinuria may be associated with improving eGFR in Japanese.
Keywords proteinuria estimated glomerular filtration rate (eGFR) lifestyle modification
Amo Type Short Communication
Published Date 2014-02
Publication Title Acta Medica Okayama
Volume volume68
Issue issue1
Publisher Okayama University Medical School
Start Page 43
End Page 46
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 24553488
Web of Sience KeyUT 000331592800007
Title Alternative Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophages
FullText URL 126_1.pdf
Author Miyamoto, Satoshi| Shikata, Kenichi| Miyasaka, Kyoko| Okada, Shinichi| Sasaki, Motofumi| Kodera, Ryo| Hirota, Daisho| Kajitani, Nobuo| Takatsuka, Tetsuharu| Kataoka Usui, Hitomi| Nishishita, Shingo| Horiguchi Sato, Chikage| Funakoshi, Akihiro| Nishimori, Hisakazu| Uchida, Haruhito Adam| Ogawa, Daisuke| Makino, Hirofumi|
Keywords cholecystokinin 糖尿病性腎症 抗炎症作用 腎保護効果
Publication Title 岡山医学会雑誌
Published Date 2014-04-01
Volume volume126
Issue issue1
Start Page 1
End Page 6
ISSN 0030-1558
Related Url http://www.okayama-u.ac.jp/user/oma/
language 日本語
Copyright Holders Copyright (c) 2014 岡山医学会
File Version publisher
DOI 10.4044/joma.126.1
Author Kitagawa, Masashi| Sugiyama, Hitoshi| Morinaga, Hiroshi| Inoue, Tatsuyuki| Takiue, Keiichi| Ogawa, Ayu| Yamanari, Toshio| Kikumoto, Yoko| Uchida, Haruhito Adam| Kitamura, Shinji| Maeshima, Yohei| Nakamura, Kazufumi| Ito, Hiroshi| Makino, Hirofumi|
Published Date 2013-02-19
Publication Title PLoS ONE
Volume volume8
Issue issue2
Content Type Journal Article
Author Kagawa, Hidetoshi| Hiromasa, Tsutomu| Hara, Takayuki| Takaki, Ayako| Yamanaka, Ryutaro| Sada, Ken-ei| Makino, Hirofumi|
Published Date 2012-10
Publication Title Clinical and Experimental Nephrology
Volume volume16
Issue issue5
Content Type Journal Article
Author Sugiyama, Koichi| Sada, Ken-ei| Kurosawa, Michiko| Wada, Jun| Makino, Hirofumi|
Published Date 2013-02
Publication Title Clinical and Experimental Nephrology
Volume volume17
Issue issue1
Content Type Journal Article
JaLCDOI 10.18926/AMO/52788
FullText URL 68_4_219.pdf
Author Hinamoto, Norikazu| Maeshima, Yohei| Saito, Daisuke| Yamasaki, Hiroko| Tanabe, Katsuyuki| Nasu, Tatsuyo| Watatani, Hiroyuki| Ujike, Haruyo| Kinomura, Masaru| Sugiyama, Hitoshi| Sonoda, Hikaru| Kanomata, Naoki| Sato, Yasufumi| Makino, Hirofumi|
Abstract Experimental studies have demonstrated the involvement of angiogenesis-related factors in the progression of chronic kidney disease (CKD). There have so far been no reports investigating the distribution and clinical roles of Vasohibin-1 (VASH-1), a negative feedback regulator of angiogenesis, in CKD. We recruited 54 Japanese CKD patients and 6 patients who had normal renal tissues excised due to localized renal cell carcinoma. We evaluated the correlations between the renal expression level of VASH-1 and the clinical/histological parameters. VASH-1 was observed in renal endothelial/mesangial cells, crescentic lesions and interstitial inflammatory cells. Significant positive correlations were observed between 1) crescent formation and the number of VASH-1+ cells in the glomerulus (r=0.48, p=0.001) or cortex (r=0.64, p<0.0001), 2) interstitial cell infiltration and the number of VASH-1+ cells in the cortex (r=0.34, p=0.02), 3) the glomerular VEGFR-2+ area and the number of VASH-1+ cells in the glomerulus (r=0.44, p=0.01) or medulla (r=0.63, p=0.01). These results suggest that the renal levels of VASH-1 may be affected by local inflammation, crescentic lesions and VEGFR-2.
Keywords chronic kidney disease inflammation Vasohibin-1 VEGF-A VEGFR-2
Amo Type Original Article
Published Date 2014-08
Publication Title Acta Medica Okayama
Volume volume68
Issue issue4
Publisher Okayama University Medical School
Start Page 219
End Page 233
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25145408
Web of Sience KeyUT 000340687500004
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/52824
JaLCDOI 10.18926/AMO/52789
FullText URL 68_4_235.pdf
Author Ono, Tetsuichiro| Shikata, Kenichi| Obika, Mikako| Miyatake, Nobuyuki| Kodera, Ryo| Hirota, Daisyo| Wada, Jun| Kataoka, Hitomi| Ogawa, Daisuke| Makino, Hirofumi|
Abstract The aim of this study was to clarify the factors associated with the remission and/or regression of microalbuminuria in Japanese patients with type 2 diabetes mellitus. We retrospectively analyzed the data of 130 patients with type 2 diabetes mellitus with microalbuminuria for 2-6 years (3.39±1.31 years). Remission was defined as improving from microalbuminuria to normoalbuminuria using the albumin/creatinine ratio (ACR), and regression of microalbuminuria was defined as a decrease in ACR of 50% or more from baseline. Progression of microalbuminuria was defined as progressing from microalbuminuria to overt proteinuria during the follow-up period. Among 130 patients with type 2 diabetes mellitus with microalbuminuria, 57 and 13 patients were defined as having remission and regression, respectively, while 26 patients progressed to overt proteinuria. Sex (female), higher HDL cholesterol and lower HbA1c were determinant factors associated with remission/regression of microalbuminuria by logistic regression analysis. Lower systolic blood pressure (SBP) was also correlated with remission/regression, but not at a significant level. These results suggest that proper control of blood glucose, BP and lipid profiles may be associated with remission and/or regression of type 2 diabetes mellitus with microalbuminuria in clinical practice.
Keywords microalbuminuria type 2 diabetes mellitus remission regression
Amo Type Original Article
Published Date 2014-08
Publication Title Acta Medica Okayama
Volume volume68
Issue issue4
Publisher Okayama University Medical School
Start Page 235
End Page 241
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2014 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 25145409
Web of Sience KeyUT 000340687500005
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/52828
Author Terasaka, Tomohiro| Otsuka, Fumio| Tsukamoto, Naoko| Nakamura, Eri| Inagaki, Kenichi| Toma, Kishio| Ogura-Ochi, Kanako| Glidewell-Kenney, Christine| Lawson, Mark A.| Makino, Hirofumi|
Published Date 2013-12-05
Publication Title Molecular and Cellular Endocrinology
Volume volume381
Issue issue1-2
Content Type Journal Article
Author Nakayama, Kazunori| Nakao, Kazushi| Takatori, Yuji| Inoue, Junko| Kojo, Shoichirou| Akagi, Shigeru| Fukushima, Masaki| Wada, Jun| Makino, Hirofumi|
Published Date 2013-12-18
Publication Title International Journal of Nephrology and Renovascular Disease
Volume volume7
Content Type Journal Article
Author Inoue, Kentaro| Wada, Jun| Eguchi, Jun| Nakatsuka, Atsuko| Teshigawara, Sanae| Murakami, Kazutoshi| Ogawa, Daisuke| Terami, Takahiro| Katayama, Akihiro| Tone, Atsuhito| Iseda, Izumi| Hida, Kazuyuki| Yamada, Masao| Ogawa, Tomohisa| Makino, Hirofumi|
Published Date 2013-10-15
Publication Title PLoS ONE
Volume volume8
Issue issue10
Content Type Journal Article