JaLCDOI 10.18926/AMO/32805
FullText URL fulltext.pdf
Author Matsuka, Yoko| Wang, Da-Hong| Suganuma, Narufumi| Imai, Kaori| Ikeda, Satoru| Taketa, Kazuhisa| Kira, Shohei|
Abstract <p>We studied the association of gamma-glutamyltransferase (GGT) and other serum markers of liver injury with daily alcohol consumption in a healthy population of 1,043 Japanese males. A positive correlation between daily alcohol consumption and biochemical markers, such as log GGT (r = 0.432), log AST (r = 0.244) or log LAP (r = 0.246), was seen in all drinkers. However, there was a negative correlation, such as log GGT (r = -0.434), log AST (r = -0.424) or log LAP (r = -0.430), in heavy drinkers who consumed more than 70 g ethanol a day. On the other hand, a positive correlation, such as log GGT (r = 0.426), log AST (r = 0.247) or log LAP (r = 0.216) was found in moderate drinkers who consumed less than 70 g ethanol a day. Interestingly, there was a tendency toward negative association between alcohol consumption and the Tokyo University ALDH2 Phenotype Screening Test (TAST) score in the heavy drinkers, and there was a tendency toward positive association between GGT and TAST score in this group. Our results suggest that there are 2 groups of drinkers, those with elevated GGT (good responders) and those with normal GGT (poor responders) despite heavy drinking.</p>
Keywords gamma-glutamyltransferase(GGT) daily alcohol consumption good responder and poor responder
Amo Type Article
Published Date 2003-08
Publication Title Acta Medica Okayama
Volume volume57
Issue issue4
Publisher Okayama University Medical School
Start Page 171
End Page 178
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 14627068
Web of Science KeyUT 000184987100002
JaLCDOI 10.18926/AMO/32284
FullText URL fulltext.pdf
Author Tsumagari, Kenji| Yamamoto, Hideki| Suganuma, Narufumi| Kato, Masahiko| Ikeda, Satoru| Imai, Kaori| Kira, Shohei| Taketa, Kazuhisa|
Abstract <p>A sharp rise in the number of patients with infectious gastroenteritis was observed in the 25th week of year 1996 in the Takahashi-Ashin district by researchers with the Infectious Disease Surveillance Program for tuberculosis and other infectious diseases in the Okayama Prefecture. This sharp rise occurred coincidentally with an outbreak of enterohemorrhagic Escherichia coli O157:H7 (EHEC O157) infection in Niimi City of the Takahashi-Ashin district. However, this phenomenon of coincidental outbreaks was not observed during the outbreak of EHEC O157 infection in Oku Cho. By reviewing outpatients' charts in a sentinel hospital in Niimi City for the Infectious Disease Surveillance Program, it was noted that patients with acute gastrointestinal infection visiting the hospital during the increased incidence of infectious gastroenteritis may have been included as misclassified cases of EHEC O157 infection. On the other hand, the exponential probability plotting of symptomatic patients with EHEC O157 infection in Niimi City revealed a breaking point which suggested a dual exposure to contaminated food or an overlap with other acute gastrointestinal infections. The latter possibility was discounted, because stool culture-positive patients with EHEC O157 infection also exhibited a similar breaking point, and furthermore, the coincidental increase in infectious gastroenteritis in the same area was attributable to the EHEC O157 infection. The present study demonstrates the association between the sharp rise in gastroenteritis and the outbreak of EHEC O157 in the Takahashi-Ashin district. A careful analysis of the cases of infectious gastroenteritis by the Infectious Disease Surveillance Program would have predicted the outbreak of EHEC O157.</p>
Keywords enterohemorrhangic Escherichia coli O157 infection infectious gastroenteritis Niimi City epidemiological studies surveillance
Amo Type Article
Published Date 2000-12
Publication Title Acta Medica Okayama
Volume volume54
Issue issue6
Publisher Okayama University Medical School
Start Page 265
End Page 273
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11132920
Web of Science KeyUT 000166042900005
JaLCDOI 10.18926/AMO/32015
FullText URL fulltext.pdf
Author Ogura, Toshio| Matsuura, Kazuharu| Suzuki, Hisao| Kishida, Masayuki| Ikeda, Satoru| Tsukamoto, Chiaki| Imai, Ayumi| Tobe, Kazuo|
Amo Type Article
Published Date 2001-11
Publication Title Acta Medica Okayama
Volume volume55
Issue issue5
Publisher Okayama University Medical School
Start Page 269
End Page 276
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
Web of Science KeyUT 000171635400002
JaLCDOI 10.18926/AMO/31934
FullText URL fulltext.pdf
Author Ikeda, Satoru|
Abstract <p>In an attempt to evaluate high density lipoprotein (HDL) subfraction levels in liver diseases, HDL was separated by a precipitation method with dextran sulfate-Mg2+ from sera of 289 healthy adults and 50 patients with liver diseases. The HDL was subdivided into HDL2e and HDL3e by Utermann's polyacrylamide gel electrophoresis with lauric acid. Ultracentrifugally separated HDL2 and HDL3 roughly corresponded to HDL2e and HDL3e, respectively. Male and female groups had different distributions of HDL2e/HDL3e ratios. Among healthy males, 121 cases had ratios less than 1.0 (mean +/- SD = 0.72 +/- 0.39, n = 150), while among healthy females, the ratios were generally larger than those of males and varied widely from 0.2 to 6.6 (mean +/- SD = 1.77 +/- 1.05, n = 139). Low levels of HDL-cholesterol were found in patients with liver diseases, except those with mild alcoholic liver injury and intrahepatic cholestasis. Apparent decreases in HDL3e, but not in HDL2e, were found in all cases with liver diseases investigated, even in those who did not show decreases in the total HDL level, when male and female patients were analyzed separately. The analysis of HDL subfractions by the present method is simple and useful for the study on altered lipid metabolism in liver diseases.</p>
Keywords HDL<sup>2</sup> HDL<sub>3</sub> HDL-cholesterol electrophoresis liver disease
Amo Type Article
Published Date 1986-06
Publication Title Acta Medica Okayama
Volume volume40
Issue issue3
Publisher Okayama University Medical School
Start Page 127
End Page 138
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 3739750
Web of Science KeyUT A1986C914800002
JaLCDOI 10.18926/AMO/31643
FullText URL fulltext.pdf
Author Uesugi, Seiichiro| Taketa, Kazuhisa| Rimal, Nirmal| Ikeda, Satoru| Kariya, Tetsu| Suganuma, Narufumi| Yamamoto, Hideki| Kira, Shohei|
Abstract <p>To better understand the spread of hepatitis C virus (HCV) infection, we studied the association of HCV infection with similarly transmissible hepatitis B virus (HBV) infection and with hepatitis A virus (HAV) infection, which is supposed to be related to a nosocomial transmission of HCV. This was done by studying the presence or absence of antibodies to these viruses, as well as hepatitis B surface antigen, in a population of 1,398 inhabitants with abnormal liver function tests or history of liver disease and/or blood transfusion. This group was drawn from a group of 7,905 examinees screened for liver disease in 26 districts of Okayama prefecture, Japan. The prevalence of antibody-positive cases increased with age for those viruses. Small but significantly increased odds ratios were obtained among anti-HCV antibodies (HCVAb), anti-hepatitis B core antibodies (HBcAb) and anti-hepatitis A antibodies (HAVAb). After adjusting odds ratios by logistic regression analysis, a significant association was present only between HCVAb and HBcAb. The distribution of age-adjusted prevalences (AAP) of HCVAb in 26 districts was significantly wider than those of HBcAb or HAVAb. The district-based AAP of HCVAb, but not of HBcAb and HAVAb, correlated significantly with the district-based prevalence of infectious hepatitis having a tendency of chronicity reported in 1953-1955. Adjusted odds ratios calculated by logistic regression analysis of the virus markers showed that HCVAb was significantly associated with a past history of blood transfusion. Thus, the spread of HCV infection is speculated to have been triggered by blood transfusion, particularly from paid donors initially, followed by transmission by nosocomial or close person-to-person contact.</p>
Keywords hepatitis A hepatitis B hepatitis C seroepidemiology route of infection blood exposure
Amo Type Article
Published Date 1999-02
Publication Title Acta Medica Okayama
Volume volume53
Issue issue1
Publisher Okayama University Medical School
Start Page 31
End Page 38
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
Web of Science KeyUT 000078897700006
JaLCDOI 10.18926/AMO/31637
FullText URL fulltext.pdf
Author Masatomi, Chie| Imai, Kaori| Wang, Da-Hong| Ikeda, Satoru| Taketa, Kazuhisa| Takata, Shinji| Kira, Shohei|
Abstract <p>The relationship between past and present lifestyle and urinary excretion of type I collagen cross-linked N-telopeptides (NTx) was studied in 61 Japanese females aged 34-59, with a view toward using NTx excretion rates as a predictor of future osteoporosis. Bone mineral density (BMD) of the lumbar spine, the speed of sound (SOS) and broadband ultrasound attenuation (BUA) of the os calcis, urinary NTx, serum osteocalcin (BGP) and bone-specific alkaline phosphatase (BAP) were measured. Stiffness index (stiffness) was calculated from SOS and BUA. The subjects were asked whether they took regular exercise in their childhood and teen years (in elementary, junior-high, senior-high school and college), the past (20-40 years of age) and present adulthood. Regular calcium intake, smoking habits, alcohol and other beverage consumption and milk consumption were also covered in the questionnaire. The mean NTx values of premenopausal and postmenopausal group were 22.2 and 56.0 nM bone collagen equivalents (BCE)/mM urinary creatinine (Cr), respectively. The group which did not exercise regularly between the ages of 20 and 40 had a higher mean NTx value (40.9 nMBCE/mMCr) than the group which did exercise regularly (22.7 nMBCE/mMCr). In multiple regression analyses, age, stiffness and exercise in past adulthood could explain 43.5% of the NTx variance. For prevention of bone metabolic increases around menopause, habitual exercise in early adulthood seems to be effective.</p>
Keywords N-telopeptides bone turnover osteoporosis menopause lifestyle
Amo Type Article
Published Date 1999-06
Publication Title Acta Medica Okayama
Volume volume53
Issue issue3
Publisher Okayama University Medical School
Start Page 133
End Page 140
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
Web of Science KeyUT 000081201100006
JaLCDOI 10.18926/AMO/31332
FullText URL fulltext.pdf
Author Matsui, Hiroaki| Rimal, Nirmal| Kamakura, Kozue| Uesugi, Seiichiro| Yamamoto, Hideki| Ikeda, Satoru| Taketa, Kazuhisa|
Abstract <p>With advances in lectin affinity electrophoresis of alpha-fetoprotein (AFP), the detection of significant changes in serum AFP at low levels in cirrhotics has become important for early detection of hepatocellular carcinoma. Serum AFP levels of 616 healthy individuals without abnormal liver function tests or virus markers of hepatitis B and C were determined by enzyme immunoassay with IMx-AFP Dainapack using automated IMx apparatus set at twice the ordinary sensitivity and compared with those of 241 individuals with abnormal liver function tests and/or positive hepatitis virus markers. The coefficient of variation in this assay was less than 10% at AFP levels as low as 0.2 ng/ml with a lower detection limit of 0.1 ng/ml. The AFP level of healthy population showed a Gaussian distribution curve after logarithmic transformation with a median and 2.5-97.5 percentile reference range of 2.2 (0.6-5.6) ng/ml. There was no significant difference in the AFP level between males and females. Individuals with abnormal liver function tests alone showed no significant increase in serum AFP unless they were associated with positive hepatitis virus markers. </p>
Keywords ?-fetoprotein enzyme immunoassay healthy japanese adults serum level reference values
Amo Type Article
Published Date 1998-06
Publication Title Acta Medica Okayama
Volume volume52
Issue issue3
Publisher Okayama University Medical School
Start Page 149
End Page 154
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 9661742
Web of Science KeyUT 000074528500005
JaLCDOI 10.18926/AMO/31329
FullText URL fulltext.pdf
Author Nishimura, Masako| Ikeda, Satoru| Taketa, Kazuhisa|
Abstract The clinical implications of a wider distribution of salivary type (S-type) isoamylase activity, as compared with that of pancreatic type (P-type) isoamylase activity in the serum of young female adults of 18-23 years old was studied. A high correlation existed between the S-type isoamylase levels in the initial determination and those in the second determination one year after on the same subjects, indicating that the wider distribution of S-type isoamylase level reflects an individual variation. The serum level of S-type isoamylase was highly correlated with the S-type isoamylase activity in saliva. Among the additional factors studied, a weak positive correlation was present between energy intake and the total and S-type isoamylase activities in serum. However, there was no negative correlation between the S-type isoamylase level and body mass index (BMI), which was reported for young male adults.
Keywords isoamylase serum saliva young female energy intake
Amo Type Article
Published Date 1998-06
Publication Title Acta Medica Okayama
Volume volume52
Issue issue3
Publisher Okayama University Medical School
Start Page 143
End Page 148
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders Copyright© 1999 Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 9661741
Web of Science KeyUT 000074528500004
Related Url http://ousar.lib.okayama-u.ac.jp/metadata/4435
JaLCDOI 10.18926/AMO/31326
FullText URL fulltext.pdf
Author Suganuma, Narufumi| Ikeda, Satoru| Taketa, Kazuhisa| Wang, Da-hong| Yamamoto, Hideki| Phornphukutkul, Kannika| Peerakome, Supatra| Sitvacharanum, Kriegsak| Jittiwutlkarn, Jaroon|
Abstract <p>An exposure to GB virus C/hepatitis G virus (GBV-C/HGV) was studied among populations at risk for blood and sexual exposure to analyze risk factor of the transmission of the virus. Blood samples were drawn from 98 intravenous drug users (IVDU), 100 female high-class commercial sex workers (CSW) and 50 male outpatients (MOP) at a sexually transmitted diseases (STD) clinic in Chiang Mai, Thailand. These blood samples were analyzed for GBV-C/HGV RNA; antibodies against second envelope protein of GBV-C/HGV (anti-E2); anti-hepatitis C virus antibody (HCV-Ab); hepatitis B core antibody (HBcAb); and antibodies against human immunodeficiency virus (HIV-Ab). Prevalences of GBV-C/HGV RNA, anti-E2, HCV-Ab, HBcAb and HIV-Ab were 27.6%, 16.3%, 84.7%, 76.5% and 45.0% in IVDU; 0%, 21.5%, 2.0%, 72.0% and 11.0% in CSW; 6.0%, 13.6%, 0%, 64.0% and 14.0% in MOP. While the prevalence of GBV-C/HGV RNA was higher in IVDU than in CSW and MOP, comparable prevalences of anti-E2 among the three populations were found. Intravenous drug injection showed association with GBV-C/HGV RNA, while history of STD associated with anti-E2. In conclusion, intravenous drug injection and STD were found to be risk factors for the previous exposure to GBV-C/HGV, but STD did not increase the risk of the GBV-C/HGV viraemia.</p>
Keywords GB virus C/hepatitis G virus anti-E2 anti-body sexualty transmitted disease human immunodeficiency virus hepatitis C virus
Amo Type Article
Published Date 1998-06
Publication Title Acta Medica Okayama
Volume volume52
Issue issue3
Publisher Okayama University Medical School
Start Page 161
End Page 167
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 9661744
Web of Science KeyUT 000074528500007
JaLCDOI 10.18926/AMO/31266
FullText URL fulltext.pdf
Author Ikeda, Satoru| Nagashima, Hideo| Taketa, Kazuhisa| Watanabe, Makoto|
Abstract <p>Effect of nicomol on high density lipoprotein (HDL) subfractions, HDL2e and HDL3e, separated by electrophoresis.</p>
Keywords HDL<sup>2</sup> HDL<sub>3</sub> HDL cholesterol electrophoresis Nicomol nicotinic acid derivative.
Amo Type Brief Note
Published Date 1981-04
Publication Title Acta Medica Okayama
Volume volume35
Issue issue2
Publisher Okayama University Medical School
Start Page 149
End Page 154
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6456646
Web of Science KeyUT A1981LS45700008
JaLCDOI 10.18926/AMO/30548
FullText URL fulltext.pdf
Author Ide, Takero| Taketa, Kazuhisa| Watanabe, Makoto| Ikeda, Satoru| Izumi, Masaki| Sokabe, Teruko| Kono, Hiroshi| Yamamoto, Yoshio|
Abstract <p>&lt;p&gt;The levels of HDL-cholesterol and gamma-glutamyltransferase in the sera of 17 patients with alcoholic liver injury were followed after abstinence and compared with those of 11 patients with acute non-alcoholic hepatitis. The activity of gamma-glutamyltransferase decreased in all cases irrespective of the type of liver injuries. The level of HDL-cholesterol also decreased in 11 of 17 cases with alcoholic liver injury. The other alcoholics, in whom HDL-cholesterol level increased or showed no definite change after withdrawal of alcohol, had severe and advanced liver injuries. In non-alcoholic hepatitis, the HDL-cholesterol level increased as normal liver functions were restored except for one case with cholestatic features. It was concluded that alcohol intake can increase HDL-cholesterol level even in the presence of a concomitantly induced hepatic lesion.&lt;/p&gt;</p>
Keywords alcoholic liver injury HDL-cholesterol ?-glutamy1-transferase.
Amo Type Article
Published Date 1980-11
Publication Title Acta Medica Okayama
Volume volume34
Issue issue5
Publisher Okayama University Medical School
Start Page 293
End Page 299
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6108050
Web of Science KeyUT A1980KT96800001
JaLCDOI 10.18926/15127
Title Alternative Spa therapy and quality of life in patients with bronchial asthma
FullText URL 066_072_077.pdf
Author Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Hosaki, Yasuhiro| Yokota, Satoshi| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa|
Abstract 気管支喘息のなかでも,ステロイド依存性重症難治性喘息では,気管支拡張薬その他の抗喘息薬のみでは発作のコントロ-ルが極めて困難であり,したがって副腎皮質ホルモンの長期投与を余儀なくされる。そして,投与薬剤,特に気管支拡張薬の心臓刺激作用や副腎皮質ホルモンの副作用,さらには運動誘発喘息がひき起こされやすいなどの理由により,体動制限が加えられることが多い。このことが,また精神活動の低下へとつながる。したがって,重症難治性喘息患者のQuality of life (QOL)を高めるためには,薬剤の副作用をできるだけ低くするための投与薬剤の減量をはかるとともに,十分な運動のもとに治療を行い全身状態の改善,それにともなう精神活動の活性化をはかる必要がある。かかる観点からすれば,温泉療法は最も理想的な治療法であり,その直接作用(気道への作用:気道浄化作用,気道粘膜正常化作用)により,白,他覚症状の改善,換気機能の改善,気道過敏性の低下などが観察される。また,間接作用(気道以外への作用)により,全身状態の改善,自律神経系の安定化作用,副腎皮質機能の改善作用などが見られる。すなわち,重症難治性喘息に対する温泉療法では,十分な運動のもとに,精神活動の活性化をともなった喘息症状の改善がはかられるため,患者のQOLをより一層高めることができると判断される。
Abstract Alternative Bronchial asthma is in qeneral a disease with good prognosis and can be controlled with usual antiasthmatic drugs. However, there are some patients whose asthma attacks can be controlled only with use of qlucocorticoids. In these patients, adverse side effects of many kinds of drugs containing bronchodilators and qlucocorticoids, and exercise-induced asthma attacks are often observed. Thus, the patients have to keep limitation of exercise during treatment of their asthma attacks, leading to decrease psychical activity. Complex spa therapy for bronchial asthma consists of swimming training in a hot spring pool (exercise), inhalation of iodine salt solution and fango therapy. Spa therapy has two kinds of actions : direct action to airways and indirect action to other organs except airways. The direct action of spa therapy improves subjective and objective symptoms, and ventilatory function, and suppress bronchial hyperresponsiveness. In contrast, improvemment of suppressed function of adrenocortical glands, of mental activity, and of autonomic nerve system is observed as indirect action of spa therapy. These actions play an important role for improvement of QOL of patients with bronchial asthma.
Keywords 温泉療法 (spa therapy) 重症難治性喘息 (lntractable asthma) 運動 (exercise) 精神活動 (phychical activity) QOL
Publication Title 岡大三朝分院研究報告
Published Date 1995-09
Volume volume66
Start Page 72
End Page 77
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307919
JaLCDOI 10.18926/15121
Title Alternative 気管支喘息患者の血清コーチゾール値について. 副腎皮質ホルモン投与および年齢との関連
FullText URL 066_030_036.pdf
Author Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa|
Abstract Serum cortisol levels were examined in 94 patients with bronchial asthma in relation to dose of glucocorticoids and age. 1. The level of serum cortisol was significantly lower in group A patients, treated with glucocorticoids (prednisolone of 5mg/day or more) for more than 2 years, (2.4±1.2mcg/㎗) than in group B, treated with glucocorticoids (prednisolone of 5mg or less) for less than 2 years, (6.8±3.7mcg/㎗) (p<0.001) and in group C, treated without glucocorticoids, (12.6±3.9mcg/㎗) (p<0.001). The serum cortisol level was also significantly lower in group B than in group C (p<0.001). 2. The level of serum cortisol was significantly lower in patients over the age of 70 compared to that in those aged between 0 and 39 years (p<0.01) and those between 40 and 49 (p<0.05), and those between 50 and 59 (p<0.02). The level was also lower in patients between 60 and 69 compared to that in those between 0 and 39, however, this was not significant. These results demonstrate that the level of serum cortisol decreases by long-term glucocorticoid regimen and with aging.
Abstract Alternative 気管支喘息94例を対象に,副腎皮質ホルモン投与および年齢との関連のもとに,血清コーチゾール値の変動を観察した。まず副腎皮質ホルモンの投与量および投与期間により以下の3群に分けて検討した。グループA :副腎皮質ホルモン,プレドニソロンに換算して1日5mg以上を2年間以上にわたり使用している症例,グループB:プレドニソロン1日5mg以下で2年間以内の使用症例, グループC:副腎皮質ホルモンを全く使用していない症例。その結果,グループAの血清コーチゾ-ル値(2.4±1.2mcg/㎗)は,グループB (6.8±3.7mcg/㎗)(p 0.01)やC(12.6±3.9mcg/㎗)(p 0.001)に比べ有意に低い値であった。2、グループCでは,70才以上の症例の血清コーチゾ-ル値は,0-39才の症例(p 0.0l),40-49才の症例(p 0.05),そして,50-59才の症例(p 0.02)に比べ有意に低い値であった。これらの結果は,血清コーチゾール値は,副腎 皮質ホルモンの投与量や投与期間以外にも、加齢による影響を受ける可能性を示唆している。
Keywords serum cortisol level (血清コーチゾール) bronchial asthma (気管支喘息) clinical asthma type (臨床病型) glucocorticoids (副腎皮質ホルモン) aging (加齢)
Publication Title 岡大三朝分院研究報告
Published Date 1995-09
Volume volume66
Start Page 30
End Page 36
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307345
JaLCDOI 10.18926/15120
Title Alternative 老年者気管支喘息の各臨床病型における換気機能の特徴
FullText URL 066_021_029.pdf
Author Hosaki, Yasuhiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa|
Abstract Ventilatory function was examined in 55 patients with asthma (25 older patients over the age of 60 and 30 younger patients under the age of 59) in relation to four clinical types classified by clinical symptoms and signs. 1. Regarding cellular composition of bronchoalveolar lavage (BAL) fluid, number of BAL neutrophils was significantly increased in type II, bronchiolar obstruction type, of older and younger patients compared to that in type la-1 and type la-2 of same patients. In contrast, BAL eosinophilia was observed in type la-2 of both older and younger patients and in type Ib of younger patients. 2. The values of % FVC, FEV(1.0%) and % PEFR were not significantly different among four clinical types of asthma and between older and younger patients, although the values of these ventilatory parameters in type II asthma showed a tendency to be lower compared to other clinical types. 3. The values of % MMF, % V(50), and % V(25), showing ventilatory dysfunction of small airways, were lowest in type II asthma of both older and younger patients among four clinical types. A significant difference in these ventilatory parameters of type II asthma compared to type la-1 asthma was observed in younger patients, but not in older patients. These results show that ventilatory dysfunction of small airways is related to clinical asthma types in younger patients, and to aging rather than asthma types in older patients.
Abstract Alternative 気管支喘息55例(老年症例-65才以上-25例,若年症例-59才以下-30例)における換気機能の特徴について,各臨床病型別に検討を加えた。1.まず対象症例の臨床病型の病態的特徴を,気管支肺胞洗浄(BAL)液中の細胞成分で検討 すると,Ⅱの細気管支閉塞型の症例では,好中球の増加が,またIa-2やIbの過分泌型の症例では好酸球の増加が特徴的であった。2.% FVC,FEVL(1.0%),% PEFRなどの換気パラメーターは,Ⅱ型において他の病型に比べ低値を示す傾向は見られたが,各病型間に有意差は見られなかった。3.% MMF,% V(50),% V(25)などのどちらかと言えば小ないし細気管支領域の換気障害を示す換気パラメーターの値は,老年および若年症例ともⅡ型(細気管支閉塞型)において最も低い値が示された。そして,若年症例では,Ⅱ型の症例においてこれからの換気パラメーターの値は,Ia-1型(単純性気管支攣縮型)に比べ有意に低い値を示した。しかし,老年症例ではⅡ型におけるこれらの換気パラメータ-の値は,他の臨床病型との問に有意の差は見られなかった。
Keywords Ventilatory function (換気機能) Clinical asthma type (臨床病型) BAL cells (BAL細胞) aging (加齢)
Publication Title 岡大三朝分院研究報告
Published Date 1995-09
Volume volume66
Start Page 21
End Page 29
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002308008
JaLCDOI 10.18926/15117
Title Alternative ダニ喘息における気道遊走細胞からのヒスタミン遊離の加齢による減少
FullText URL 066_001_007.pdf
Author Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Hosaki, Yasuhiro| Yokota, Satoshi| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa|
Abstract Histamine release from bronchoalveolar cells induced by house dust mite (HDm) was compared in patients with atopic asthma sensitive to HDm in relation to age. 1. Total cell number in bronchoalveolar lavage (BAL) fluid was larger in patients over the age of 40 years (9.10×10(6)) than in those aged between 20 and 39 years (6.25×10(6)), however, this was not significant. 2. Number of BAL eosinophils was not significantly different between the two age groups. 3. Number of BAL basophilic cells was significantly higher in younger patients (20-39 years) (1.85±1.03×10(2)/mℓ) than in older patients (40+ years) (0.39±0.24×10(2)/mℓ) (p<0.001). 4. Histamine release from BAL cells induced by HDm was significantly higher in younger patients (38.1±24.8%) than in older patients (0%) (p<0.001). These results suggest that histamine release from BAL cells in patients with HDm allergy decreases with aging.
Abstract Alternative ダニ喘息14例を対象に,ハウスダストエキスによる気道遊走細胞からのヒスタミン遊離と加齢との関連について検討を加えた。1.気管支肺胞洗浄液(BALF)中の総細胞数は,20-39才の症例群(6.25×10(6)) に比べ,40才以 上の症例群(9.1×10(6)) でやや多い傾向が見られたが,推計学的には有意差は見られなかった。2.BALF中好酸球数は,20-39才と40才以上の症例群間に差は見られなかった。3.BALF中好塩基性細胞数は,40才以上の症例群(0.39±0.24×10(2)/mℓ)に比べ,20-39才の症例群(1.85±1.03×10(2)/mℓ)において有意に多い傾向が見られた(P<0.001)。4.ハウスダストエキスによるBALF中細胞からのヒスタミン遊離は,40才以上の症例群(0%) に比べ20-39才の症例群(38.1±24.8%)において有意に高い結果が得られた(P<0.001)。これらの結果より,ダニ喘息(アトピー型喘息)における気道遊走細胞からのヒスタミン遊離は,加齢とともに減少することが示唆された。
Keywords Bronchial asthma House dust allergy Histamine release Bronchoalveolar cells
Publication Title 岡大三朝分院研究報告
Published Date 1995-09
Volume volume66
Start Page 1
End Page 7
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307845
JaLCDOI 10.18926/15091
Title Alternative Ⅱ型喘息(細気管支閉塞型)と気管支肺胞洗浄液の好中球数
FullText URL 067_079_084.pdf
Author Tanizaki, Yoshiro| Mifune, Takashi| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Yokota, Satoshi| Tsugeno, Hirofumi| Takeuchi, Kazuaki| Nawa, Yuichiro| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa|
Abstract Bronchial asthma is classified into three types ; type Ia (Ia-1 and Ia-2), type Ib, and type Ⅱ, by clinical symptoms (clinical diagnosis). Asthma is also classified by clinical findings and examinations (score diagnosis). Both classification systems show that markedly increased proportion of BAL neutrophils and marked decrease in % V25 value are characteristic of type Ⅱ, bronchiolar obstruction, asthma. However, there are some type Ⅱ asthma patients without BAL neutrophilia. In these patients, age is higher compared to those with BAL enutrophlia. Decrease in FEV1.0% value and decrease in the proportion of BAL lympocytes and serum IgG level, are not so remarkable as decrease in those with BAL neutrophilia. It has been suggested that type Ⅱ asthma with BAL neutrophilia correlates with suppression of humoral and cellular immunity, and same type of astma without BAL neutrophilia is in part caused by aging.
Abstract Alternative 気管支喘息は,その臨床症状より,Ia型(Ia-1およびIa-2),Ib型およびⅡ型の3つの病型に分けることができる(臨床分類)。また,同時に臨床所見および検査により分類することができる(スコアー分類)。いずれの分類においても,BAL液中の好中球の著増および高度な% V25値の低下がⅡ細気管支閉塞型の特徴的所見である。しかしながら,BAL液中の好中球の増加をともなわないⅡ型喘息が存在することが明らかにされている。これらの症例では,BAL液 中好中球増加をともなう症例に比べ平均年齢が高い。しかし,FEVl.0% 値、BAL液中リンパ球頻度や血清IgG値などは、好中球増加をともなう症例ほどの低下傾向は見られない。これらの結果はBAL液中好中球増加をともなうⅡ型z喘息の発症機序には、液性および細胞性免疫能の低下が、また、BAL液中好中球増加をともなわないⅡ型喘息では、加齢がある程度関連していることを示 している。
Keywords Asthma classification (喘息分類) BAL lymphocytes (BALリンパ球) BAL neutrophils (BAL好中球) % V25 value Ⅱ型喘息
Publication Title 岡大三朝分院研究報告
Published Date 1996-11
Volume volume67
Start Page 79
End Page 84
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307924
JaLCDOI 10.18926/15088
Title Alternative サーモグラフィーによる体表面温度の測定
FullText URL 067_063_070.pdf
Author Hosaki, Yasuhiro| Nawa, Yuichiro| Takeuchi, Kazuaki| Tsugeno, Hirofumi| Ashida, Kozo| Yokota, Satoshi| Mitsunobu, Fumihiro| Mifune, Takashi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Ikeda, Satoru| Taketa, Kazuhisa|
Abstract Body Surface Temperature was observed by thermography. The surface temperature of a healthy person's lower limbs, after being cooled in a water bath, increased in parallel with time. Patients with Diabetes Mellitus had different patterns in the rate of increase of the surface temperature. After cold loading, one patient had a 99% recovery ratio of surface temperature, the same level as healthy volunteers (83%, and 88%), as calculated by a picture processing program with the computerized thermotracer. However, the recovery ratio of other patients was poorer, ranging from 56% to under 6% recovery. This measurement of elevation of body temperature is useful for the estimation of peripheral blood flow in patients with lower limbcirculation failure.
Abstract Alternative 健常人並びに糖尿病患者を対象にして下肢の体表面温度を測定した。測定にはサーモグラフィーを用い,得られた画像の数値化にはコンピュータを用いた画像処理システムを利用した。健常人を用いた実験では,20℃の水を用いた冷水負荷を5分間行うことにより,冷水負荷後,下肢の体表面温度は時間とともに上昇して30分後に良好な回復を得ることができた。画像処理により28℃以上の体表面温度を呈した下肢の面積を負荷前と比較したところ,回復率は,2名の健常人についてみるとそれぞれ83%,88%であった。27℃で画像処理を行った場合には回復率は93%となり過大評価される可能性があった。また,29℃で画像処理を行ったところに,逆に,64%となり過少評価される可能性があり,28℃が最も良い条件であった。この様な条件下で,糖尿病患者7名について同様に測定を行ったところ,1名は健常人と同じく99%の良好な回復率を呈した。しかし,他の1名は56%であり,残りの,5名は6%以下であった。この様に,糖尿病患者では,下肢の体表面温度の冷水負荷後の回復率に顕著な差を認めた。この差は,糖尿病患者における,末梢循環障害の程度を反映しているものと考えられた。この様にコンピュータを用いた画像処理システムの応用によりサーモグラフィーの画像は数値化することが出来,測定結果はより客観的に据えることが可能となった。画像処理されたサーモグラフィーは下肢の循環障害を持つ患者の末梢血流量の評価に有用な測定方法であると考えられた。
Keywords Thermography (サーモグラフィー) Diabetes Mellitus (糖尿病) Peripheral Circulation (末梢循環) Cold Loading (冷水負荷)
Publication Title 岡大三朝分院研究報告
Published Date 1996-11
Volume volume67
Start Page 63
End Page 70
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307566