このエントリーをはてなブックマークに追加
ID 47015
JaLCDOI
FullText URL
Author
Matsumoto, Yoshinori
Takano, Mariko
Toyota, Noriko
Yamanaka, Ryutaro
Sugiyama, Koichi
Otsuka, Fumio Kakenhi
Makino, Hirofumi
Abstract
It is well known that infection is one of the major causes of morbidity and mortality in rheumatic disease patients treated with high-dose glucocorticoids, especially in the early phase after achievement of disease remission. The aim of this study was to identify the risk factors for infection, with a focus on the dose of glucocorticoids administered, following the achievement of disease remission in rheumatic diseases patients. We retrospectively analyzed the medical records of rheumatic disease patients who had been treated with glucocorticoids. The primary endpoint was the incidence rate of infection during a period from 1 to 2 months after the commencement of treatment. From April 2006 to March 2010, 19 of 92 patients suffered from infection during the observation period. Age≧65 yrs, presence of interstitial pneumonia, diagnosis of systemic vasculitis and serum creatinine level≧2.0mg/dl were found to be univariate predictors for infection. However, only the presence of interstitial pneumonia was an independent risk factor for infection (HR=4.50, 95%CI=1.65 to 14.44) by the Cox proportional hazard model. Even after achievement of clinical remission, careful observation is needed for patients with interstitial pneumonia, more so than for those receiving high-dose glucocorticoids.
Keywords
infection
rheumatic disease
glucocorticoids
interstitial pneumonia
risk factors
Amo Type
Original Article
Published Date
2011-10
Publication Title
Acta Medica Okayama
Volume
volume65
Issue
issue5
Publisher
Okayama University Medical School
Start Page
329
End Page
334
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
Copyright Holders
CopyrightⒸ 2011 by Okayama University Medical School
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT