Author Obika, Masanari| Ogawa, Hiroko| Takahashi, Katsuyuki| Li, Jiayi| Hatipoglu, Omer Faruk| Cilek, Mehmet Zeynel| Miyoshi, Toru| Inagaki, Junko| Ohtsuki, Takashi| Kusachi, Shozo| Ninomiya, Yoshifumi| Hirohata, Satoshi|
Published Date 2012-10
Publication Title Cancer Science
Volume volume103
Issue issue10
Content Type Journal Article
Author Matsuura, Hiroko| Murakami, Takashi| Hina, Kazuyoshi| Yamamoto, Keizo| Kawamura, Hiroshi| Sogo, Taiji| Shinohata, Ryoko| Usui, Shinichi| Ninomiya, Yoshifumi| Kusachi, Shozo|
Published Date 2008-02
Publication Title Clinical Biochemistry
Volume volume41
Issue issue3
Content Type Journal Article
Author Toeda, Kenichi| Nakamura, Keigo| Hirohata, Satoshi| Hatipoglu, Omer F.| Demircan, Kadir| Yamawaki, Hitoshi| Ogawa, Hiroko| Kusachi, Shozo| Shiratori, Yasushi| Ninomiya, Yoshifumi|
Published Date 2005-12
Publication Title Molecular and Cellular Biochemistry
Volume volume280
Issue issue1-2
Content Type Journal Article
JaLCDOI 10.18926/AMO/32213
FullText URL fulltext.pdf
Author Cheng, Xiao-shu| Kusachi, Shozo| Urabe, Norio| Nogami, Kunio| Takemoto, Masao| Morishita, Naoya| Haraoka, Shoichi| Tsuji, Takao|
Abstract <p>The association between the extent of left ventricular (LV) hypertrophy and severity of ventricular or atrial arrhythmias are examined. Two-dimensional echocardiography and 24-h Holter electrocardiography monitoring were performed in 60 patients with hypertrophic cardiomyopathy (HCM). According to the distribution of the LV hypertrophy, the patients were divided into three groups: 1. Apical hypertrophy (APH), 2. Septal hypertrophy, and 3. Extensive hypertrophy. Ventricular arrhythmias were found in 82% of the patients and supraventricular arrhythmias were detected in 70% of the patients. Lown grade III and IV arrhythmias occurred significantly more frequently in patients with extensive than with septal hypertrophy. Lown grade III to IV arrhythmias did not occur in patients with APH. Present results show a significant association between the extent of LV hypertrophy and the severity of ventricular arrhythmias in HCM. &#60;/P&#62;</p>
Keywords hypertrophic cardiomyopathy arrhythmia echocardiography Holter ECG
Amo Type Article
Published Date 1991-06
Publication Title Acta Medica Okayama
Volume volume45
Issue issue3
Publisher Okayama University Medical School
Start Page 155
End Page 159
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1832510
Web of Science KeyUT A1991FV15000005
JaLCDOI 10.18926/AMO/31831
FullText URL fulltext.pdf
Author Hatipoglu, Omer Faruk| Hirohata, Satoshi| Yaykasli, Kursat Oguz| Cilek, Mehmet Zeynel| Demircan, Kadir| Shinohata, Ryoko| Yonezawa, Tomoko| Oohashi, Toshitaka| Kusachi, Shozo| Ninomiya, Yoshifumi|
Abstract <p>ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs 1) is an inflammatory-induced gene. We have previously reported that ADAMTS1 was strongly but transiently expressed in the infarcted heart. In this study, we investigated whether a 3'-untranslated region (UTR) affects the mRNA stability of this gene. When stimulated with tissue necrosis factor (TNF)-alpha, the expression level of ADAMTS1 mRNA rapidly increased, but the induction of ADAMTS1 mRNA peaked at 6h after stimulation, after which the expression levels of ADAMTS1 mRNA decreased. The 3'-UTR ADAMTS1 mRNA contains multiple adenine and uridine-rich elements, suggesting that the 3'-UTR may regulate gene stability. The addition of actinomycin D, an RNA synthesis inhibitor, demonstrated the decay of induced ADAMTS1 mRNA by TNF-alpha. Furthermore, a region containing multiple AUUUA motifs within the ADAMTS1 3'-UTR destabilized transfected Enhanced Green Fluorescence Protein (EGFP) mRNA expression. These results demonstrated that the ADAMTS1 3'-UTR may regulate the expression of ADAMTS1 mRNA.</p>
Keywords ADAMTS1 gene regulation metalloproteinase
Amo Type Original Article
Published Date 2009-04
Publication Title Acta Medica Okayama
Volume volume63
Issue issue2
Publisher Okayama University Medical School
Start Page 79
End Page 85
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 19404339
Web of Science KeyUT 000265457600002
JaLCDOI 10.18926/AMO/30893
FullText URL fulltext.pdf
Author Kusachi, Shozo| Iwasaki, Kohichirou| Nishiyama, Osamu| Ueda, Minoru| Kita, Toshimasa| Hata, Takato| Taniguchi, Gyou| Watanabe, Hirofumi| Hina, Kazuyoshi| Saito, Daiji| Tsuji, Takao| Haraoka, Shoichi|
Abstract <p>We studied the factors which may induce acute high grade restenosis in emergency percutaneous transluminal coronary angioplasty (PTCA). PTCA was attempted in 50 patients with acute myocardial infarction, and the balloon catheter passed successfully across the occlusion site in 47 (94%) of the patients. These 47 patients were analyzed. &#34;Acute restenosis&#34; was defined as a lesion which was revascularized to less than 50% luminal reduction narrowed again to more than 75% luminal reduction 5 min after the balloon inflation. Univariate and multivariate analyses were used for determining factors which significantly influenced acute restenosis. The incidence of at least one restenosis episode was 45%. Multiple regression analysis selected 5 factors associated significantly with an increased rate of acute restenosis: 1) angiographic evidence of dissection, 2) lesion in the right coronary artery (RCA), 3) lack of or insufficient administration of thrombolytic agent preceding PTCA, 4) curved lesion and 5) relatively small balloon/artery diameter ratio. Acute restenosis correlated significantly with late reocclusion. This study indicates that it is important to administer a thrombolytic agent prior to emergency PTCA, and to use an adequately sized balloon to the artery when the acute restenosis occurs by using relatively smaller sized balloon. The present data also demonstrated that patients with RCA and a curved lesion have a relatively high risk of acute restenosis. This study indicates how patients with relatively high risk of acute restenosis may be identified.</p>
Keywords emergency coronary angioplasty restenosis acute myocardial infarction multivariate analysis
Amo Type Article
Published Date 1989-02
Publication Title Acta Medica Okayama
Volume volume43
Issue issue1
Publisher Okayama University Medical School
Start Page 55
End Page 63
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 2524153
Web of Science KeyUT A1989T938500007
JaLCDOI 10.18926/AMO/30538
FullText URL fulltext.pdf
Author Saito, Daiji| Kusachi, Shozo| Nishiyama, Osamu| Yasuhara, koichiro| Yoshida, Hidenori| Haraoka, Shoichi|
Abstract <p>The effects of changes in distal resistance on stenotic resistance were studied in vitro. Physiological saline was passed through the left carotid artery obtained from the dog, flexible rubber tubing, or through solid polyethylene tubing with a constant perfusion pressure or with a constant flow rate. Various stenotic resistances were established using a screw type constrictor and the distal resistance was varied by allowing physiological saline to pass through either a 23 gauge hypodermic needle (high peripheral resistance) or 23 and 20 gauge needles (low peripheral resistance ). For arteries with anatomically fixed stenosis, the calculated resistance was increased in association with reduction of the distal resistance. The stenotic resistance in the flexible rubber tubing changed in the same manner as that of the carotid artery, while the solid polyethylene tubing showed no significant stenotic resistance changes due to altering the distal resistance. These findings suggest that the stenotic resistance change of the artery correlates with the elasticity of the vessel wall and also indicate that resistance values were of little usefulness for evaluating the effects of vasodilating stimuli on the vessel segment with a significant stenosis.</p>
Keywords stenotic resistance constant perfusion pressure constant flow rate.
Amo Type Article
Published Date 1980-04
Publication Title Acta Medica Okayama
Volume volume34
Issue issue2
Publisher Okayama University Medical School
Start Page 109
End Page 115
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6450512
Web of Science KeyUT A1980JY15600004
Author Haraoka, Shoichi| Saito, Daiji| Ueda, Minoru| Ogino, Yasuhiro| Kusuhara, Shunichi| Yoshida, Hidenori| Kawasaki, Tomoko| Miyasaka, Minoru| Yoshioka, Nobuhiko| Ikenaga, Toyotake| Kusachi, Shozo| Sogo, Yasushi| Yamada, Nobuyuki| Nishiyama, Osamu| Yasuhara, Koichiro| Hisamatsu, Mitsuo| Nukada, Kaname| Imada, Kakuro| Hirata, Takako| Kasu, Yoshiko|
Published Date 1978-12-30
Publication Title 岡山医学会雑誌
Volume volume90
Issue issue11-12
Content Type Journal Article
Author Haraoka, Shoichi| Saito, Daiji| Ueda, Minoru| Ogino, Yasuhiro| Kusuhara, Shunichi| Yoshida, Hidenori| Kawasaki, Tomoko| Miyasaka, Minoru| Yoshioka, Nobuhiko| Ikenaga, Toyotake| Kusachi, Shozo| Sogo, Yasushi| Yamada, Nobuyuki| Nishiyama, Osamu| Yasuhara, Koichiro| Hisamatsu, Mitsuo| Nukada, Kaname| Imada, Kakuro| Hirata, Takako| Kasu, Yoshiko|
Published Date 1978-12-30
Publication Title 岡山医学会雑誌
Volume volume90
Issue issue11-12
Content Type Journal Article
Author Haraoka, Shoichi| Saito, Daiji| Ueda, Minoru| Ogino, Yasuhiro| Kusuhara, Shunichi| Yoshida, Hidenori| Kawasaki, Tomoko| Miyasaka, Minoru| Yoshioka, Nobuhiko| Ikenaga, Toyotake| Kusachi, Showzo| Sogo, Taiji| Yamada, Nobuyuki| Nishiyama, Osamu| Yasuhara, Koichiro| Hisamatsu, Mitsuo| Ioriya, Kazuo| Nukada, Kaname| Imada, Kakuro| Hirata, Takako| Kasu, Yoshiko|
Published Date 1979-12-30
Publication Title 岡山医学会雑誌
Volume volume91
Issue issue11-12
Content Type Journal Article
Author Yoshida, Hidenori| Kusuhara, Shunichi| Yoshioka, Nobuhiko| Kusachi, Showzo| Sogo, Taiji| Yamada, Nobuyuki| Nishiyama, Osamu| Yasuhara, Koichiro| Ueda, Minoru| Saito, Daiji| Mae, Ritsuo| Shimada, Yoshihiro| Matsuura, Hidemitsu| Omori, Hiroyuki| Kimoto, Katsuhiko| Shigei, Hiroshi| Haraoka, Shoichi|
Published Date 1979-04-30
Publication Title 岡山医学会雑誌
Volume volume91
Issue issue3-4
Content Type Journal Article
Author Yoshida, Hidenori| Uesugi, Seiichiro| Yuasa, Shiro| Kusachi, Showzo| Sogo, Taiji| Yamada, Nobuyuki| Nishiyama, Osamu| Yasuhara, Kouichiro| Ueda, Minoru| Saito, Daiji| Mae, Ritsuo| Shimada, Yoshihiro| Haraoka, Shoichi|
Published Date 1979-04-30
Publication Title 岡山医学会雑誌
Volume volume91
Issue issue3-4
Content Type Journal Article
Author Haraoka, Shoichi| Saito, Daiji| Ueda, Minoru| Ogino, Yasuhiro| Kusuhara, Shunichi| Yoshida, Hidenori| Kawasaki, Tomoko| Misayaka, Minoru| Yoshioka, Nobuhiko| Ikenaga, Toyotake| Kusachi, Showzo| Sogo, Taiji| Yamada, Nobuyuki| Nishiyama, Osamu| Yasuhara, Koichiro| Hisamatsu, Mitsuo| Nukada, Kaname| Imada, Kakuro| Hirata, Takako| Kasu, Yoshiko|
Published Date 1979-02-28
Publication Title 岡山医学会雑誌
Volume volume91
Issue issue1-2
Content Type Journal Article
Author Haraoka, Shoichi| Yoshida, Hidenori| Saito, Daiji| Ueda, Minoru| Kusachi, Shozo| Nishiyama, Osamu| Yasuhara, Koichiro| Yamada, Nobuyuki| Ihoriya, Kazuo| Fujii, Akinobu| Kimura, Shoji| Takeda, Ko| Hyodo, Tatsuo| Uchida, Toshiaki| Nishihara, Masanobu| 吉田 暎| 日下 幸恵|
Published Date 1981-06-30
Publication Title 岡山医学会雑誌
Volume volume93
Issue issue5-6
Content Type Journal Article
Author Kusachi, Shozo|
Published Date 1983-06-30
Publication Title 岡山医学会雑誌
Volume volume95
Issue issue5-6
Content Type Journal Article
Author Nakagawa, Hiroshi| Kusachi, Shozo| Oka, Takefumi| Urabe, Norio| Nogami, Kunio| Takemoto, Masao| Morishita, Naoya| Inoue, Kimihito| Tsuji, Takao| Tomita, Susumu|
Published Date 1992
Publication Title 岡山医学会雑誌
Volume volume104
Issue issue5-6
Content Type Journal Article
Author 草地 省藏|
Published Date 1984-03-31
Publication Title
Content Type Thesis or Dissertation