Author Fujita, Hirofumi| Shiosaka, Masahiko| Ogino, Tetsuya| Okimura, Yuya| Utsumi, Toshihiko| Sato, Eisuke F.| Akagi, Reiko| Inoue, Masayasu| Utsumi, Kozo| Sasaki, Junzo|
Published Date 2008-06-23
Publication Title Brain Research
Volume volume1206
Content Type Journal Article
JaLCDOI 10.18926/AMO/30712
FullText URL fulltext.pdf
Author Omori, Masako| Toyoda, Hiroshi| Hirai, Takeshi| Ogino, Tetsuya| Okada, Shigeru|
Abstract Angiomyofibroblastoma is a rare, usually small benign mesenchymal tumor that occurs in vulvar lesions of premenopausal women. A case of angiomyofibroblastoma that arose as a unique pedunculated and particularly large mass in the left vulva of a 48-year-old woman is presented herein. The patient had been aware of a gradually enlarged mass of 7 years duration without any other gynecological symptoms or signs. The maximum dimension of the tumor measured 11 cm. The resected tumor was well circumscribed with a bulging and glistening cut surface. Histological examination revealed an admixture of irregularly distributed hypercellular and hypocellular areas with spindled, plump spindled, or plasmacytoid stromal cells and abundant venular or capillary-sized vessels. Stromal cells characteristically cluster around delicate vessels within an edematous to collagenous matrix. In the present case, intralesional adipose tissue was present throughout the tumor. There was no significant nuclear atypia, and mitotic figures were very sparse. There was little stromal mucin throughout the tumor. Immunohistochemically, the stromal cells were characterized by strong reactivity for vimentin and CD34, with focal reactivity for desmin and alpha smooth muscle actin. Both estrogen and progesterone receptors were diffusely expressed in the stromal cells. These histological findings are consistent with angiomyofibroblastoma and support the hypothesis that angiomyofibroblastoma originates from perivascular stem cells with a capacity for myofibroblastic and fatty differentiation.
Keywords angiomyofibroblastoma vulva adipose tissue pedunculated mass
Amo Type Article
Published Date 2006-08
Publication Title Acta Medica Okayama
Volume volume60
Issue issue4
Publisher Okayama University Medical School
Start Page 237
End Page 242
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 16943862
Web of Sience KeyUT 000239911100006
Author 寳迫 睦美| 荻野 哲也| 岡田 茂|
Published Date 2006-01-04
Publication Title 岡山医学会雑誌
Volume volume117
Issue issue3
Content Type Journal Article
Author 荻野 哲也|
Published Date 1988-03-28
Publication Title
Content Type Thesis or Dissertation