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ID 31855
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Author
Takahashi, Hide K.
Katayama, Hiroshi
Mori, Shuji
Iwagaki, Hiromi
Tanaka, Noriaki
Morita, Kiyoshi
Abstract
Lipopolysaccharide (LPS) is one of the major causes of septic shock. The polymyxin B-immobilized filter column (PMX) was developed for the adsorption of endotoxin by direct hemoperfusion and has been used for the treatment of LPS-induced septic shock. In this study, we demonstrated that PMX also specifically bound monocytes from the peripheral blood leukocytes of septic patients by mean of an analysis of bound cells using immunocytochemical and electron microscopic techniques. The specific removal of monocytes from septic patients may produce beneficial effects by reducing the interaction between monocytes and functionally associated cells including vascular endothelial cells.
Keywords
septic shock
polymixin B-immobilized column
monocyte
adsorptive removal
Amo Type
Short Communication
Published Date
2009-02
Publication Title
Acta Medica Okayama
Volume
volume63
Issue
issue1
Publisher
Okayama University Medical School
Start Page
65
End Page
69
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
Web of Sience KeyUT