FullText URL CTR375_3_743.pdf
Author Ojima, Fumiya| Saito, Yuka| Tsuchiya, Yukiko| Ogoshi, Maho| Fukamachi, Hiroshi| Inagaki, Kenichi| Otsuka, Fumio| Takeuchi, Sakae| Takahashi, Sumio|
Keywords Estrogen Follicle Mouse Ovary Runx3
Published Date 2018-10-30
Publication Title Cell and Tissue Research
Volume volume375
Issue issue3
Publisher Springer
Start Page 743
End Page 754
ISSN 0302-766X
NCID AA00600105
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
File Version author
PubMed ID 30377784
DOI 10.1007/s00441-018-2947-2
Web of Science KeyUT 000460535300015
Related Url isVersionOf https://doi.org/10.1007/s00441-018-2947-2
Title Alternative Transcription factor Runx3 in the mouse hypothalamo-pituitary-gonadal system
FullText URL poalas_034_002.pdf
Author Takahashi, Sumio|
Abstract Runx3 is a transcription factor that belongs to the Runx family. Female Runx3 knockout (Runx3−⁄−) mouse was anovulatory and infertile. Ovarian transplantation experiment suggested that lack of ovulation in Runx3−⁄− mice was caused by alteration of gonadotropin secretion in Runx3−⁄− mice. Cyp11a1 mRNA expression was less in Runx3−⁄− mouse ovaries than in wt ones. Hypothalamic Gnrh1 mRNA was increased, and Kiss1 mRNA expression in the anteroventral periventricular nucleus was decreased, but Kisspeptin mRNA in the arcuate nucleus was increased in Runx3-/- mice. Pituitary Fshb mRNA levels were increased in Runx3−⁄− mice. Cholesterol side-chain cleavage enzyme gene (Cyp11a1) expression was decreased in ovaries of Runx3−⁄− mice. These findings suggest that anovulation in Runx3−⁄− mice was partly due to the alterations in hypothalamus-pituitary-ovary system. Runx3 plays a key role in female reproduction through alteration of gonadotropin secretion.
Publication Title Proceedings of Okayama Association for Laboratory Animal Science
Published Date 2018-04
Volume volume34
Start Page 2
End Page 4
language 日本語
File Version publisher
Title Alternative Identification of Marker Gene of Pars Tuberalis Morphogenesis in Chicken Embryo. The expression of Cytokine-like 1 and Gap junction protein alpha 5 in the pars tuberalis
FullText URL poalas_033_031_034.pdf
Author Aizawa, Sayaka | Higaki, Yuriko| Ogoshi, Maho| Takeuchi, Sakae| Takahashi, Sumio|
Abstract Adenohypophysis delivered from oral ectoderm consists of pars distalis (PD), pars intermedia and pars tuberalis (PT). The mechanisms of development of PD has been well studied, and the cell differentiation of PD has been well understood. However, the morphogenesis and the differentiation of PT are still unclear, and the gene expression during the PT development remains largely unknown. In this study, we explored the specifically expressing genes in PT during development and analyzed its spatiotemporal expressions pattern. Microarray analysis on laser-captured PT and PD tissues obtained from chicken embryos on embryonic day 10 (E10.0) showed high expressing genes, Cytokine-like 1 (CYTL1) and Gap junction protein alpha 5 (GJA5) in PT. A detail analysis of spatiotemporal expressions pattern during chick embryo development by in situ hybridization revealed that CYTL1 mRNA was first detected in lateral head ectoderm and ventral head ectoderm in E1.5. The CYTL1 expressions moved into Rathke’s pouch at E2.5, then it was localized in PT primordium and continuously expressed in PT primordium until E12.0. On the other hand, GJA5 mRNA was transiently detected in PT primordium from E6 to E14.0, while the expression was not detected in PD during development. These results suggested that these genes may be involved in the regulation mechanism of PT development and could be a useful marker in the PT development.
Publication Title Proceedings of Okayama Association for Laboratory Animal Science
Published Date 2017-04
Volume volume33
Start Page 31
End Page 34
language 日本語
File Version publisher
Author Kugimoto, Ayako| Aizawa, Sayaka| Ogoshi, Maho| Takahashi, Sumio| Takeuchi, Sakae|
Published Date 2016-04
Publication Title Proceedings of Okayama Association for Laboratory Animal Science
Volume volume32
Content Type Journal Article
Author Tokumori, Megumi| Ogoshi, Maho| Takeuchi, Sakae| Takahashi, Sumio|
Published Date 2015-04
Publication Title 岡山実験動物研究会報
Volume volume31
Content Type Journal Article
Author Takahashi, Toru| Nishio, Kaori| Ogoshi, Maho| Takahashi, Sumio| Takeuchi, Sakae|
Published Date 2014-04
Publication Title 岡山実験動物研究会報
Volume volume30
Content Type Journal Article
Author Ohtsuki, Takashi| Otsuki, Mariko| Murakami, Yousuke| Maekawa, Tetsuya| Yamamoto, Takashi| Akasaka, Koji| Takeuchi, Sakae| Takahashi, Sumio|
Published Date 2005-09
Publication Title Zoological Science
Volume volume22
Issue issue9
Content Type Journal Article
Author Kusumoto, Kenji| Murakami, Yousuke| Otsuki, Mariko| Kanayama, Munetoshi| Takeuchi, Sakae| Takahashi, Sumio|
Published Date 2005-09
Publication Title Zoological Science
Volume volume22
Issue issue9
Content Type Journal Article
Author Rajapakse, Sanath| Ogiwara, Katsueki| Yamano, Noriko| Kimura, Atsushi| Hirata, Kensaku| Takahashi, Sumio| Takahashi, Takayuki|
Published Date 2006-11
Publication Title Zoological Science
Volume volume23
Issue issue11
Content Type Journal Article
Author Ohtsuki, Takashi| Otsuki, Mariko| Murakami, Yousuke| Hirata, Kensaku| Takeuchi, Sakae| Takahashi, Sumio|
Published Date 2007-03
Publication Title Zoological Science
Volume volume24
Issue issue3
Content Type Journal Article
Author Maekawa, Tetsuya| Takeuchi, Sakae| Kanayama, Munetoshi| Takahashi, Sumio|
Published Date 2009-02
Publication Title Zoological Science
Volume volume26
Issue issue2
Content Type Journal Article
Author Honda, Junichi| Takeuchi, Sakae| Fukumachi, Hiroshi| Takahashi, Sumio|
Published Date 1998-08
Publication Title Zoological Science
Volume volume15
Issue issue4
Content Type Journal Article
Author Morooka, Yoshiaki| Oomizu, Souichi| Takeuchi, Sakae| Takahashi, Sumio|
Published Date 1998-08
Publication Title Zoological Science
Volume volume15
Issue issue4
Content Type Journal Article
Author Shiraga, Masahiro| Komatsu, Noriko| Teshigawara, Kiyoshi| Okada, Akinobu| Takeuchi, Sakae| Fukamachi, Hiroshi| Takahashi, Sumio|
Published Date 2000-07
Publication Title Zoological Science
Volume volume17
Issue issue5
Content Type Journal Article
Author Kakeya, Tomoshi| Takeuchi, Sakae| Takahashi, Sumio|
Published Date 2002-07
Publication Title Zoological Science
Volume volume19
Issue issue7
Content Type Journal Article
Author Sharma, Seema| Oomizu, Souichi| Kakeya, Tomoshi| Masui, Tohru| Takeuchi, Sakae| Takahashi, Sumio|
Published Date 2003-01
Publication Title Zoological Science
Volume volume20
Issue issue1
Content Type Journal Article
Author Komatsu, Noriko| Maekawa, Tetsuya| Takeuchi, Sakae| Takahashi, Sumio|
Published Date 2003-05
Publication Title Zoological Science
Volume volume20
Issue issue5
Content Type Journal Article
Author Takahashi, Sumio|
Published Date 2004-06
Publication Title Zoological Science
Volume volume21
Issue issue6
Content Type Journal Article
Author Taniuchi, Shusuke| Takahashi, Sumio| Takeuchi, Sakae|
Published Date 2011-05
Publication Title 岡山実験動物研究会報
Volume volume27
Content Type Journal Article
Author Tsuchiya, Yukiko| Sakuma, Atsuko| Takeuchi, Sakae| Takahashi, Sumio|
Published Date 2011-05
Publication Title 岡山実験動物研究会報
Volume volume27
Content Type Journal Article