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ID 52783
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Author
Ariyoshi, Yuichi
Mahmood, Sabina
Ishii, Kazushi
Nagai, Atsushi
Abstract
Gender identity disorder (GID) results from a disagreement between a person's biological sex and the gender to which he or she identifies. With respect to the treatment of female to male GID, testosterone replacement therapy (TRT) is available. The uric acid (UA) level can be influenced by testosterone; however, the early effects and dose-dependency of TRT on the serum UA concentration have not been evaluated in this population. We herein conducted a dose-response analysis of TRT in 160 patients with female to male GID. The TRT consisted of three treatment groups who received intramuscular injections of testosterone enanthate: 125 mg every two weeks, 250 mg every three weeks and 250 mg every two weeks. Consequently, serum UA elevation was observed after three months of TRT and there was a tendency toward testosterone dose-dependency. The onset of hyperuricemia was more prevalent in the group who received the higher dose. We also demonstrated a positive correlation between increased levels of serum UA and serum creatinine. Since the level of serum creatinine represents an individual's muscle volume and the muscle is a major source of purine, which induces UA upregulation, the serum UA elevation observed during TRT is at least partially attributed to an increase in muscle mass. This is the first study showing an association between serum UA elevation and a TRT-induced increase in muscle mass. The current study provides important information regarding TRT for the follow-up and management of the serum UA levels in GID patients.
Keywords
Gender identity disorder
Testosterone
Uric acid
Creatinine
Muscle
Published Date
2013-12
Publication Title
Endocrine Journal
Volume
volume60
Issue
issue12
Start Page
1321
End Page
1327
ISSN
0918-8959
Content Type
Journal Article
language
英語
Copyright Holders
©The Japan Endocrine Society
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publisher
Refereed
True
DOI
Web of Sience KeyUT